MnO<sub>2</sub>nanoparticles as a minimalist multimode vaccine adjuvant/delivery system to regulate antigen presenting cells for tumor immunotherapy

Song, Ting; Liao, Yang; Zuo, Qinhua; Liu, Zonghua; Liu, Ning

doi:10.1039/d1tb02650j

Cited by 16 publications

(14 citation statements)

References 44 publications

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“…This MnO 2 @ MPDA-PEG nanosystem thus could be a promising dual-imaging theragnostic nanodrug to potentiate the systemic antitumor immunity. Song et al used model antigen ovalbumin (OVA) to construct tumor vaccine OVA/MnO 2 to test the mechanism and efficacy of MnO 2 based tumor vaccine adjuvant/delivery system (80). As an advanced adjuvant pool, MnO 2 nanoparticles can continuously release Mn 2+ and enhance the immune response through the cGAS-STING pathway in DCs.…”

Section: Mno 2 Nanoparticles Based Therapeutic Strategies By Manipula...mentioning

confidence: 99%

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Zhang

et al. 2023

Front. Immunol.

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As an essential micronutrient, manganese plays an important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous and endogenous DNA for activation, has been widely reported to play critical roles in the innate immunity against some important diseases, such as infections and tumor. Manganese ion (Mn2+) has been recently proved to specifically bind with cGAS and activate cGAS-STING pathway as a potential cGAS agonist, however, is significantly restricted by the low stability of Mn2+ for further medical application. As one of the most stable forms of manganese, manganese dioxide (MnO2) nanomaterials have been reported to show multiple promising functions, such as drug delivery, anti-tumor and anti-infection activities. More importantly, MnO2 nanomaterials are also found to be a potential candidate as cGAS agonist by transforming into Mn2+, which indicates their potential for cGAS-STING regulations in different diseased conditions. In this review, we introduced the methods for the preparation of MnO2 nanomaterials as well as their biological activities. Moreover, we emphatically introduced the cGAS-STING pathway and discussed the detailed mechanisms of MnO2 nanomaterials for cGAS activation by converting into Mn2+. And we also discussed the application of MnO2 nanomaterials for disease treatment by regulating cGAS-STING pathway, which might benefit the future development of novel cGAS-STING targeted treatments based on MnO2 nanoplatforms.

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Section: Mno 2 Nanoparticles Based Therapeutic Strategies By Manipula...mentioning

confidence: 99%

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Zhang

et al. 2023

Front. Immunol.

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“… 22 Therefore, nanoMn was considered a novel and effective adjuvant that could be used in various prophylactic and therapeutic vaccines. 25 − 27 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, nanoMn could be phagocytosed by macrophages to promote their polarization to the M1 phenotype and the recruitment of monocytes for immune response augmentation . Therefore, nanoMn was considered a novel and effective adjuvant that could be used in various prophylactic and therapeutic vaccines. − …”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive and Biodegradable Mn₃(PO₄)₂·3H₂O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

Zhou

Zhang

You

et al. 2023

ACS Appl. Mater. Interfaces

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Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of great significance to enhance vaccine efficacy. In this work, we prepared a long-term stable, pH-sensitive, and biodegradable Mn 3 (PO 4 ) 2 ·3H 2 O nanoparticle (nano-MnP) by simply mixing MnCl 2 /NaH 2 PO 4 /Na 2 HPO 4 solution for the first time and employed it as an immune stimulant in the bivalent COVID-19 protein vaccine comprised of wild-type S1 (S1-WT) and Omicron S1 (S1-Omicron) proteins as antigens to elicit a broad-spectrum immunity. The biological experiments indicated that the nano-MnP could effectively activate antigen-presenting cells through the cGAS–STING pathway. Compared with the conventional Alum-adjuvanted group, the nano-MnP-adjuvanted bivalent vaccine elicited approximately 7- and 8-fold increases in IgG antibody titers and antigen-specific IFN-γ secreting T cells, respectively. Importantly, antisera of the nano-MnP-adjuvanted group could effectively cross-neutralize the SARS-CoV-2 and its five variants of concern (VOCs) including Alpha, Beta, Gamma, Delta, and Omicron, demonstrating that this bivalent vaccine based on S1-WT and S1-Omicron proteins is an effective vaccine design strategy to induce broad-spectrum immune responses. Collectively, this nano-MnP material may provide a novel and efficient adjuvant platform for various prophylactic and therapeutic vaccines and provide insights for the development of the next-generation manganese adjuvant.

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“…MnO 2 shows enzyme-like reaction profiles and substrate specificities, which can be applied as effective nanozymes for biosensing and therapy purposes [ [12] , [13] , [14] ]. There are various forms of MnO 2 structures including nanofibers [ 15 ], nanosheets [ 16 ], nanoparticles [ 17 , 18 ] and so on. Two-dimensional nanosheets have been found to possess many unusual properties with good flexibility [ [19] , [20] , [21] ].…”

Section: Introductionmentioning

confidence: 99%

MnO2@Au nanostructures supported colorimetric biosensing with duplex-specific nuclease-assisted DNA structural transition

Ma¹,

Zhou²,

Li³

et al. 2023

Materials Today Bio

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MnO₂nanoparticles as a minimalist multimode vaccine adjuvant/delivery system to regulate antigen presenting cells for tumor immunotherapy

Abstract: In the field of tumor immunotherapy, tumor vaccines have unique advantages including less side effect, tumor-specificity and immune memory, and hence attract more and more attention. In the development of...

Cited by 16 publications

References 44 publications

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

pH-Sensitive and Biodegradable Mn₃(PO₄)₂·3H₂O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

MnO2@Au nanostructures supported colorimetric biosensing with duplex-specific nuclease-assisted DNA structural transition

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MnO2nanoparticles as a minimalist multimode vaccine adjuvant/delivery system to regulate antigen presenting cells for tumor immunotherapy

Abstract: In the field of tumor immunotherapy, tumor vaccines have unique advantages including less side effect, tumor-specificity and immune memory, and hence attract more and more attention. In the development of...

Cited by 16 publications

References 44 publications

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

MnO2@Au nanostructures supported colorimetric biosensing with duplex-specific nuclease-assisted DNA structural transition

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Product

Resources

About

MnO₂nanoparticles as a minimalist multimode vaccine adjuvant/delivery system to regulate antigen presenting cells for tumor immunotherapy

pH-Sensitive and Biodegradable Mn₃(PO₄)₂·3H₂O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity