Mn(II), Co(III), Ni(II), Cd(II) and Cu(II) Complexes of 2‐Thenoyltrifluoroacetone: Syntheses, Structures, Photoluminescence, Thermal, Electrochemical and Antitumor Studies on Dalton's Lymphoma Cells

Abstract

Five complexes [Mn(ttfa)2(py)2] (1), [Co(ttfa)3] (2), [Ni(ttfa)2(en)] (3), [Cd(ttfa)2(bpy)] (4), and [Cu(ttfa)2(py)] (5) {where Httfa=2‐thenoyltrifluoroacetone} have been synthesized and characterized by elemental analyses, IR, UV‐Vis and single crystal X‐ray diffraction data. Both oxygen atoms of ttfa chelate with the metal ions forming six‐membered C3O2M chelate rings in the complexes. In complexes 1–4 the metal ion adopts a distorted octahedral geometry while the complex 5 is distorted square pyramidal. In the solid state, complexes are stabilized by various types of inter‐intramolecular interactions. Upon excitation at about 29500 cm−1, complexes 1, 2, 3 and 5 exhibit blue emissions while the complex 4 emits violet colour. Electrochemical studies of Httfa and complexes show irreversible redox behavior. Thermal degradation of the complexes as analyzed by TG‐DTA suggests the formation of their respective metal oxides as final thermally stable chemical entities. Httfa, complex 1 and 5 are studied for cytotoxicity on Dalton's lymphoma cells using MTT assay, apoptotic analysis and DNA fragmentation assay which reveals their order of activity as complex 5 > complex 1 > Httfa.

Long Chain Effects on DNA‐Binding and Cytotoxicity to Cancer Cells in Metallo‐Supramolecular Oligomers

“…To know about the apoptosis induction of A549 cells by the oligomers we studied the cell apoptosis assay using annexin V‐FITC/PI staining by flow cytometry. Early stages of apoptosis cells showed Annexin V positive and PI negative, whereas in case of late stages of apoptosis both were positive (Figure ) . The chain length effect on apoptosis/necrosis induction is illustrated in Fig.…”

Electrocatalytic oxygen evolution and antiproliferative activity of Co(III) complexes stabilized by in situ generated bis(5‐furan/phenyl‐1,2,4‐triazole)‐3‐sulfinamide

“…Both complexes show significant advancement over previous reports against DL cells especially complex 2 with IC 50 value of 5 μM. [26][27][28][53][54][55][56][57] electrochemical studies reveal remarkable activity of complexes towards OER. High OER activity and high stability of complex 2 under OER operative environment as compared with complex 1 can make complex 2 a promising candidate to replace the highly expensive noble metal-based catalysts.…”

“…We evaluated the in vitro cytotoxicity of newly synthesized complexes and all components involved in synthesis of complexes on DL cells by using an MTT assay as reported previously. [26] The results obtained show that salt cobalt acetate, free ligands Haftt and Haptt, and complex 1 and complex 2 reduce cell viability in DL cells (Figure 7). All the complexes induced cytotoxic response in a concentration-dependent manner.…”

“…[24] Most of these reports about 50% rely on noble metal platinum, [25] whereas only a few reports are available on non-noble metals like Mn, Co, and Ni. [26][27][28] Also, the activity of metallodrugs against Dalton's lymphoma (DL) cells is not explored much. So, it will be of interest to study the effect of non-noble metal complexes against DL cells through the metal ligated chemical complexes.…”

Isolation and Characterization of Different Homometallic and Heterobimetallic Complexes of Nickel and Zinc Ions by Controlling Molar Ratios and Solvents

“…This could be the reason for the non‐fluorescent nature of complexes 4 – 5 which contain Ni II ions. However, few Ni II –Schiff base complexes have been reported which show fluorescence properties , …”