MMUNOHISTOCHEMICAL ANALYSIS OF NF-kB (P0/P) IN PATIENT WITH AGGRESSIVE AND CHRONIC PERIODONTITIS

Abstract

Background: Nuclear factor-kappaB (NF-κB) is a protein complex that plays a role in transcription factors and in response to inflammation. Periodontitis is a periodontal disorder caused by various bacteria such as A. actinomycetemcomitan and P.gingivalis whose LPS is closely related to 000). It shows that if the protein expression of NF-κB (p50) of the respondents is incremented by 1 (one) unit, the risk of chronic periodontitis increases 1.64 times. Box plot diagram shows that the distribution of the protein expression of NF-κB (p50) between patients with aggressive periodontitis and chronic periodontitis patients is significantly different. In NF-κB (p65)the Z value was -7.137 and significance of 0000, with α = 5%, showed significant differences in protein expression of between patients with aggressive periodontitis and chronic periodontitis. OR estimates for protein expression of . This indicates that if the protein expression of has more influence on the incidence of chronic periodontitis patients, so it can be used as a marker for chronic periodontitis.

Alveolar Bone Osteoclast Profile in the Periodontitis Wistar Rats Model with the Snail Slime (Achatina Fulica) Application

“…IL-6 type cytokine families are cytokines consisting of IL-6, IL-11, leukaemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin-1, and neutrophil-1 / B cell stimulatory factors 3. These agents use the same receptor subunit, gp130, as a signal [19].…”

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway for periodontal tissue regeneration in rats

“…Nuclear Factor-κB is a transcription factor and essential for the detection of activation of the innate immune response because their activation is associated with the TLR2/TLR4 receptors in the innate immune system [13]. In periodontitis bacteria that play a role are the P. gingivalis and A. actinomycetemcomitan in which LPS activates germ cells using the TLR2 pathway and/or TLR4 [5,11]. The interaction between LPS/TLR will activate NF-κB which plays a role in activating inflammatory mediators' transcription [13,32,35].…”

“…NF-κB resides in the cytoplasm in an inactive form along with a regulatory protein I-κB. The interaction between LPS/TLR activates the transcription NF-κB which plays a role in activating the transcription of inflammatory mediators [3,9,11]. NF-κB is activated by LPS in THP-1 cells, the transcription factor NF-kB is associated with metabolic and inflammatory responses, including nuclear receptors, activators of protein (AP-1), and early growth response (EGR).…”

“…NF-κB is activated by LPS in THP-1 cells, the transcription factor NF-kB is associated with metabolic and inflammatory responses, including nuclear receptors, activators of protein (AP-1), and early growth response (EGR). Furthermore, it is suggested that IKK/NF-kB is a target for the treatment of periodontitis disorders [10][11][12].…”

The effect of bitter gourd (Momordica charantia) ethanolic extract on inflammatory infiltrates and NF-κB activation in periodontitis

“…When periodontopathogenic infections 7 occur, these bacteria activate the NF-κB transcription factor through Toll Like Receptor (TLR) stimulation, which is expressed in nonspecific immune cells, including macrophage cells, dendritic, and mucosal epithelium. 5 Bitter gourd plant (Momordica charantia) is beneficial to the health of the human body. It (Momordica charantia) can be used as traditional medicine in the treatment of several diseases, as well as in inflammatory conditions.…”