MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer

Klassen, liliane Maria Bacaro; Chequin, Andressa; Manica, Graciele Cristiane More; Biembengut, Isis V.; Toledo, Mariana Busato; Baura, Valter A.; Pedrosa, Fábio de Oliveira; Ramos, Edneia A.S.; Costa, Fabrício F.; Souza, Emanuel Maltempi de; Klassen, Giseli

doi:10.1016/j.gene.2017.11.054

Cited by 39 publications

(28 citation statements)

References 29 publications

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“…A recent study stated that GM-CSF and MMP-9 promote the protumorigenic effect of WAT progenitors on local and metastatic breast cancer [ 20 ]. Some other study noted that MMP-9 could be regulated by DNA methylation in breast cancer, which might resulted in the first step of metastasis through extracellular matrix degradation [ 21 ]. Previously, two meta-analyses published by Song et al, [ 22 ] and Ren et al, [ 12 ] have verified that MMP-9 overexpression predicted a higher risk for OS and RFS in patients with breast carcinoma; however, few studies have been reported referring the prognostic value of serum MMP-9.…”

Section: Discussionmentioning

confidence: 99%

Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

et al. 2018

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BackgroundThis study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC).MethodsA total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were included in this study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum level of Matrix metalloproteinase-9 (sMMP-9) at baseline and prior to surgery. Immunohistochemistry was used to detect histological MMP-9 (hMMP-9) expression in patients with residual tumors after NAC. The value of MMP-9 to predict the response to NAC and patient survival was studied.ResultsOf the 303 patients, 103 (34.0%) patients experienced pathological complete response (pCR) after completion of NAC. Univariate and multivariate analyses revealed that the relative change in sMMP-9, rather than sMMP-9 at baseline or surgery, had a remarkable predictive value for pCR. Each 1 ng/ml decrease in sMMP-9 after NAC was shown to result in a 0.3% increase in pCR rate. Additionally, in survival analyses, hMMP-9 expression in residual tumors was independently correlated with disease-free survival for non-pCR responders (P < 0.001).ConclusionsOur findings indicate that monitoring serum MMP-9 and detection of histological MMP-9 could help identify TNBC patients who will respond to NAC and will display varying risks of disease relapse. MMP-9 may serve as a predictive and prognostic biomarker for tailoring and modifying the NAC strategy for TNBC.

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Section: Discussionmentioning

confidence: 99%

Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

et al. 2018

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“…43 MMP9 overexpression hydrolyzes the basement membrane and promotes cancer cell invasion and migration. 44 ADAMTS14 encodes a combination of integrin and metalloproteinases, which is linked to the progression of liver cancer. 45 There are also reported that BMP1 associated with poor prognosis of renal clear cell carcinoma, 46 and RUNX2 can promote breast cancer proliferation, migration, invasion and epithelial-mesenchymal transition.…”

Section: Dovepressmentioning

confidence: 99%

<p>The Clinical Significance of <em>PPEF1</em> as a Promising Biomarker and Its Potential Mechanism in Breast Cancer</p>

Ye¹,

Wan²,

Li³

et al. 2020

OTT

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Background: Breast cancer (BC) is the leading cause of malignancy death in females worldwide. While intense efforts have been made to elucidate the pathogeny, the molecular mechanism of BC remains elusive. Thus, this study aimed to investigate the role of PPEF1 in the progression of BC and further explore the better clinical significance. Methods: The diagnostic and prognostic values of elevated PPEF1 expression in BC were unveiled via public databases analysis. In addition, Gene Ontology (GO), Gene Set Enrichment Analysis (GSEA) and Protein-protein interaction (PPI) analysis were performed to explore the potential functions and molecular mechanisms of PPEF1 in BC progression. Experimentally, transwell and CCK-8 assays were carried out to estimate the effects of PPEF1 on the BC metastasis. Meanwhile, the differential expressions of PPEF1 in paraffin-embedded tissues and serum samples were, respectively, analyzed by Immunohistochemical (IHC) analysis and enzyme-linked immunosorbent assay (ELISA) kit. Results: The transcriptional levels of PPEF1 were higher in BC than in normal breast tissues or adjacent normal tissues. Moreover, survival analysis revealed that higher PPEF1 expression was negatively associated with overall survival (OS), all events-free (AE-free) and metastatic recurrence-free (MR-free) survival, and further was an independent risk factor of unfavorable prognosis in BC patients. Additionally, the present study provided the first evidence that PPEF1 participated in multiple biological processes and underly signaling pathways involving in tumorigenesis and development of BC. Furthermore, PPEF1 promotes the BC progression and can be used as a noninvasive diagnostic marker. Noteworthy, the combined determination of serum PPEF1 and traditional tumor markers can enhance diagnostic accuracy thus is of vital importance in the early diagnosis of BC. Conclusion: PPEF1 exerted a tumorigenic role and involved in molecular mechanism of tumorigenesis in BC which served as a promising biomarker for prognosis and diagnosis.

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“…12,13 MMP-9 allows early stage/carcinoma in situ to progress into invasive disease and influences the later development of metastasis. Several cancers express high levels of MMP-9 expression, such as colon carcinoma, 14 ovarian carcinoma, 15 lung carcinoma 16 and breast carcinoma, 17 which are associated with metastasis. 18 Significant expression of TSP-2 in developing blood vessels suggests that it is key to the regulation of primary angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Thrombospondin‐2 stimulates MMP‐9 production and promotes osteosarcoma metastasis via the PLC, PKC, c‐Src and NF‐κB activation

Liu

Chen

Chang³

et al. 2020

J Cellular Molecular Medi

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MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer

Cited by 39 publications

References 29 publications

Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

<p>The Clinical Significance of <em>PPEF1</em> as a Promising Biomarker and Its Potential Mechanism in Breast Cancer</p>

Thrombospondin‐2 stimulates MMP‐9 production and promotes osteosarcoma metastasis via the PLC, PKC, c‐Src and NF‐κB activation

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