MMP-7 (− 181A &gt; G) promoter polymorphisms and risk for cervical cancer

Singh, Harpreet; Jain, Meenu; Mittal, Balraj

doi:10.1016/j.ygyno.2008.03.007

Cited by 32 publications

(19 citation statements)

References 26 publications

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“…The G allele of the MMP7 -181 A/G SNP creates a putative binding site for a heat shock transcription factor, thereby increasing MMP7 gene promoter activity and transcription compared to the -181 A allele [34]. The G allele has been reported as a potential risk factor for several gynecological disorders, including endometriosis and adenomyosis [32], as well as endometrial [27], ovarian [26], and cervical cancers [28]. Moreover, the presence of the G allele has been associated with increased levels of malondialdehyde, a marker of lipid peroxidation, in severe preeclampsia [33].…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we extended this analysis to MMP7 and 12 genes, both of which exert important functions in pregnancy, including implantation and remodeling of spiral arteries. Additionally, polymorphisms in these genes have been investigated in different disorders, including gynecological [26][27][28] and non-gynecological cancers [29][30][31], as well as reproductive disorders [32,33] and various systemic disorders [34][35][36]. Our aim was to evaluate the potential association between IRSA in Slovenian reproductive couples and MMP7 -181 A/G and MMP12 -82 A/G functional SNPs, which are located in gene promoter regions.…”

Section: Introductionmentioning

confidence: 99%

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Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

Barišić

Pereza

Hodžić

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study was to investigate the potential association of matrix metalloproteinase 7 (MMP7) -181 A/G and MMP12 -82 A/G functional single nucleotide polymorphisms (SNP) with idiopathic recurrent spontaneous abortion (IRSA) in Slovenian reproductive couples. Methods A case-control study was conducted on 149 couples with 3 or more consecutive idiopathic spontaneous pregnancy loses and 149 women and men with at least 2 live births and no history of pregnancy complications. Genotyping of MMP7 -181 A/G and MMP12 -82 A/G SNPs was performed using polymerase chain reaction and restriction fragment length polymorphism methods. Results There were no statistically significant differences in the distribution of MMP7 -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary IRSA. We also found no association of MMP7 -181 A/G and MMP12 -82 A/G genotypes, alleles, and haplotypes with IRSA. Conclusions We found no evidence to support the association between IRSA and MMP7 -181 A/G and MMP12 -82 A/G SNPs in Slovenian reproductive couples.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

Barišić

Pereza

Hodžić

et al. 2016

J Assist Reprod Genet

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“…In contrast, in the Caucasian population, the frequency of GG genotype was lower in gastric cancer (28). In the Indian population, the MMP7 Ϫ181GG genotype was at a significantly higher risk of cervical cancer (41) and contributed to squamous cell gastric cancer susceptibility in the Kashmir Valley (36).…”

Section: Discussionmentioning

confidence: 99%

Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk

Kesh

Subramanian

Ghosh

et al. 2015

Journal of Biological Chemistry

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Background: Effect of tobacco carcinogen nicotine on MMP7 transcription and gastric cancer risk remains unknown. Results: Preferential binding of pCREB, induced by nicotine, to G-allele promoter enhanced the transcription and thus aggravated gastric cancer risk. Conclusion: Nicotine shows an additive effect over MMP7 GG genotype toward gastric cancer risk. Significance: These findings may help in the clinical management of gastric cancer.

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“…[55][56][57][58][59] Extracellular matrix (ECM) degradation enzymes were demonstrated as risk factor. [60][61][62] Vitamin-D is antiproliferative and is reported to induce apoptosis in human bladder tumor cells in vivo. [63] Fok-I polymorphism of its receptor (VDR) was found to be associated with prostate and bladder cancer.…”

Section: Genetic Polymorphisms and Cancer Riskmentioning

confidence: 99%

Indian studies on genetic polymorphisms and cancer risk

Bag¹,

Jyala²,

Bag³

2012

Indian J Cancer

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Genetic influences on cancer development have been extensively investigated during the last decade following publication of human genome sequence. The present review summarizes case-control studies on genetic polymorphisms and cancer risk in Indians. It is observed that the most commonly studied genes in the Indian population included members of phase I and phase II metabolic enzymes. Other than these genes, genetic polymorphisms for cell cycle and apoptosis-related factors, DNA repair enzymes, immune response elements, growth factors, folate metabolizing enzymes, vitamin/hormone receptors, etc., were investigated. Several studies also evidenced a stronger risk for combined genotypes rather than a single polymorphism. Gene-environment interaction was also found to be a determining factor for cancer development in some experiments. Data for single polymorphism and single cancer type, however, was insufficient to validate an association. It appears that much more experiments involving larger sample size, cross-tabulating genetic polymorphisms and environmental factors are required in order to identify genetic markers for different cancers in Indian populations.

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MMP-7 (− 181A > G) promoter polymorphisms and risk for cervical cancer

Cited by 32 publications

References 26 publications

Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

Functional single nucleotide polymorphisms of matrix metalloproteinase 7 and 12 genes in idiopathic recurrent spontaneous abortion

Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk

Indian studies on genetic polymorphisms and cancer risk

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