Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk

Kesh, Kousik; Subramanian, Lakshmi; Ghosh, Nillu; Gupta, Vinayak; Gupta, Akash; Bhattacharya, Samir; Mahapatra, Nitish R.; Swarnakar, Snehasikta

doi:10.1074/jbc.m114.630129

Cited by 35 publications

(14 citation statements)

References 56 publications

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“…The increased transcription of MMP-7 was also associated with development and progression of prostate cancer in human both in vitro [ 64 , 65 ] and in vivo [ 64 ]. Analyses performed in cell lines revealed that G allele in rs11568818 correlates with higher MMP-7 expression and enzyme activity [ 39 , 66 ]. Our result supports the observations about the role of MMP-7 in prostate cancer development.…”

Section: Discussionmentioning

confidence: 99%

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population

et al. 2018

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IntroductionProstate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland.MethodsThe study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measured and 5 single nucleotide polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13, MT2A genes were genotyped.ResultsThe mean serum zinc level was higher in prostate cancer patients than in healthy controls (898.9±12.01 μg/l vs. 856.6±13.05 μg/l, p<0.01). When compared in quartiles a significant association of higher zinc concentration with the incidence of prostate cancer was observed. The highest OR (OR = 4.41, 95%CI 2.07–9.37, p<0.01) was observed in 3rd quartile (>853.0–973.9 μg/l). Among five analyzed genetic variants, rs11568818 in MMP-7 appeared to be correlated with 2-fold increased prostate cancer risk (OR = 2.39, 95% CI = 1.19–4.82, p = 0.015).ConclusionOur results suggest a significant correlation of higher serum zinc levels with the diagnosis of prostate cancer. The polymorphism rs11568818 in MMP-7 gene was also associated with an increased prostate cancer risk in Poland.

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Section: Discussionmentioning

confidence: 99%

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population

et al. 2018

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“…According to the literature, the A to G substitution at the -181 position influences the binding of various nuclear proteins resulting in a higher transcriptional activity [ 10 ]. A computational analysis also revealed that the -181G variant of MMP-7 gene causes a higher binding affinity of a cAMP-response element-binding protein and a stronger transcriptional activity [ 43 ]. It has also been found that subjects carrying the -181GG genotype have higher MMP-7 activity compared to those with the -181AA genotype [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…A computational analysis also revealed that the -181G variant of MMP-7 gene causes a higher binding affinity of a cAMP-response element-binding protein and a stronger transcriptional activity [ 43 ]. It has also been found that subjects carrying the -181GG genotype have higher MMP-7 activity compared to those with the -181AA genotype [ 43 ]. This SNP has also been shown to correlate with the development of several kinds of tumors and chronic pancreatitis, as well as with coronary artery disease [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…This SNP has also been shown to correlate with the development of several kinds of tumors and chronic pancreatitis, as well as with coronary artery disease [ 44 ]. In this regard, Kesh and colleagues [ 43 ] showed increased expression of MMP-7 in cancer patients carrying the GG genotype. A significant association was also retrieved between the -181AA genotype and higher plasmatic levels of MMP7 among idiopathic pulmonary fibrosis patients [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

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Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

et al. 2017

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Aims The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians. Methods Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters were determined according to standard protocols. PCR-RFLP and ELISA were used to determine the genetic variants and levels of MMPs, respectively. Results The MMP-3 45Glu (G) allele associates with higher anthropometric values and MMP-3 levels compared to AA genotype carriers (BMI (kg/m2): 30 ± 0.51 versus 27.33 ± 0.8, P = 0.004; MMP-3 levels: 7.45 (4.77–11.91) versus 5.21 (3.60–10.21) ng/ml, P = 0.006). The MMP-12 -82G allele was also associated with higher BMI values when compared to subjects carrying the AA genotype (31.41 ± 0.85 versus 28.76 ± 0.43, P < 0.001). Individuals carrying the MMP-3 45G or MMP-12 -82G variants were also associated with a higher risk for severe forms of obesity (MMP-3: OR = 1.9, P = 0.002; MMP-12: OR = 2.63, P = 0.003). Similarly, the MMP-7 -181G allele was associated with a higher MMP-7 level and an increased risk for morbid obesity when compared to AA genotype carriers (0.32 (0.31–0.60) versus 0.18 (0.17–0.24) ng/ml, P = 0.01; OR = 1.67, P = 0.02, resp.). Conclusion MMP-3, MMP-7, and MMP-12 polymorphisms associate with obesity risk and its severity.

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“…The MMP-7 A-181G polymorphism influences the binding of nuclear proteins and promoter activity, thus modulating gene expression [20,21]. Higher promoter activity (2-3 times) in the presence of the MMP-7 -181G allele compared to the -181A allele in U937 cells has been attributed to the presence of a putative binding site (NGAAN) for the heat shock transcription factor in the MMP-7 -181G allele that is absent in the -181A allele [22]. There are inconsistent reports related to the role of MMP-7 A-181G variants in cancer development.…”

Section: Discussionmentioning

confidence: 99%

MMP-7 A-181G Polymorphism in Breast Cancer Patients from Western Iran

et al. 2015

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Background: Matrix metalloproteinases (MMPs) are upregulated in tumors. The MMP-7 A-181G polymorphism is associated with increased expression of the MMP-7 gene. Aim of the present study was to investigate the association between the MMP-7 A-181G polymorphism and susceptibility to breast cancer. Patients and Methods: The MMP-7 A-181G variants were studied in a cohort of 251 subjects consisting of 100 breast cancer patients and 151 healthy controls; all were from Western Iran. The MMP-7 A-181G genotypes were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequencies of the MMP-7 AA, AG, and GG genotypes in healthy individuals were 34.4, 50.4, and 15.2%, respectively. In breast cancer patients, the frequencies of AA (34%), AG (52%), and GG (14%) genotypes (p = 0.95) were similar to those in the controls. There was a trend toward an increased frequency of the combined genotype of MMP-7 AG+GG in patients with lymph node metastasis (70.4%) compared to those without metastasis (66.7%). Also, in patients with invasive lobular carcinoma, the frequency of the MMP-7 AG+GG genotype tended to be higher (71.4%) compared to that in patients with invasive ductal carcinoma (66.2%) (p = 0.78). Conclusion: Our findings indicate that the MMP-7 A-181G polymorphism may not be correlated with susceptibility to breast cancer in our population.

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Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk

Cited by 35 publications

References 56 publications

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population

Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population

Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

MMP-7 A-181G Polymorphism in Breast Cancer Patients from Western Iran

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