MMP-2-Activatable Photoacoustic Tumor Imaging Probes Based on Al- and Si-Naphthalocyanines

“…16c). 198 Their design is based on a photostable NIR naphthalocyanine scaffold which is conjugated to a PEG moiety through a MMP-2 substrate sequence. Cleavage of the peptide results in a naphthalocyanine (MNc) product that is poorly soluble in aqueous media and thus, spontaneously aggregates in solution.…”

Section: Activatable Pa Probesmentioning

confidence: 99%

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

2022

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“…The creation of H‐aggregates increased the PA signal at 680 nm and decreased at 760 nm, which might be utilized to monitor MMP‐2 in vivo. [ 201 ]…”

Section: “Turn‐on” Pa Imaging Probesmentioning

confidence: 99%

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Zeng

Dou

et al. 2022

Advanced Science

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Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificity of PA imaging and to offer diagnostic information for illnesses. The existing PA contrast agents are categorized into two groups in this review: “always‐on” and “turn‐on,” based on their ability to be triggered by target molecules. The present state of these probes, their merits and limitations, and their future development, is explored.

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“…To increase the biocompatibility of photoacoustic probes, Miki et al. designed aluminum and silicon naphthalocyanines (AlNc and SiNc) that were conjugated with the PLGLAG peptide sequence specific to MMP-2 and PEG as axial ligands (Figure a,b) . The obtained MNc-peptide-PEG conjugates (M represented Al or Si) formed nanometer-sized spherical self-assemblies in water.…”

Section: Tumor Microenvironment-activatable Photoacoustic Imagingmentioning

confidence: 99%

Section: Tumor Microenvironment-activatable Photoacoustic Imagingmentioning

confidence: 99%

Acoustic-Based Theranostic Probes Activated by Tumor Microenvironment for Accurate Tumor Diagnosis and Assisted Tumor Therapy

Tian

Ren

et al. 2022

ACS Sens.

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Acoustic-based imaging techniques, including ultrasonography and photoacoustic imaging, are powerful noninvasive approaches for tumor imaging owing to sound transmission facilitation, deep tissue penetration, and high spatiotemporal resolution. Usually, imaging modes were classified into "always-on" mode and "activatable" mode. Conventional "always-on" acoustic-based probes often have difficulty distinguishing lesion regions of interest from surrounding healthy tissues due to poor target-tobackground signal ratios. As compared, activatable probes have attracted attention with improved sensitivity, which can boost or amplify imaging signals only in response to specific biomolecular recognition or interactions. The tumor microenvironment (TME) exhibits abnormal physiological conditions that can be used to identify tumor sections from normal tissues. Various types of organic dyes and biomaterials can react with TME, leading to obvious changes in their optical properties. The TME also affects the selfassembly or aggregation state of nanoparticles, which can be used to design activatable imaging probes. Moreover, acoustic-based imaging probes and therapeutic agents can be coencapsulated into one nanocarrier to develop nanotheranostic probes, achieving tumor imaging and cooperative therapy. Satisfactorily, ultrasound waves not only accelerate the release of encapsulated therapeutic agents but also activate therapeutic agents to exert or enhance their therapeutic performance. Meanwhile, various photoacoustic probes can convert photon energy into heat under irradiation, achieving photoacoustic imaging and cooperative photothermal therapy. In this review, we focus on the recently developed TME-triggered ultrasound and photoacoustic theranostic probes for precise tumor imaging and targeted tumor therapy.

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MMP-2-Activatable Photoacoustic Tumor Imaging Probes Based on Al- and Si-Naphthalocyanines

Abstract: https://repository.kulib.kyoto-u.ac.jp -2-K.M. and N.I. conceived and designed the research; N.I. and K.N. executed the synthetic experiments; K.M., N.I., K.N., M.O., H.M., W.H., and H.H. executed the biological experiments; K.O. directed the project and wrote the paper with K.M.

Cited by 10 publications

References 41 publications

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Acoustic-Based Theranostic Probes Activated by Tumor Microenvironment for Accurate Tumor Diagnosis and Assisted Tumor Therapy

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