Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Zhao, Zhenxiang; Swartchick, Chelsea B; Chan, Jefferson

doi:10.1039/d0cs00771d

Cited by 80 publications

(66 citation statements)

References 364 publications

(386 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different from fluorescence imaging, photoacoustic (PA) imaging is a hybrid imaging modality based on the near‐infrared (NIR) excitation with thermal‐ultrasonic detection, enabling deeper tissue penetration relative to fluorescence imaging [10] . Activatable PA imaging probes that only trigger the signals in the presence of specific molecular biomarkers offer measurable and quantifiable information on physiological and pathological status at the molecular level [11] . Among many PA agents including gold nanoparticles, [12] carbon‐based nanomaterials, [13] hemicyanine, [14] and dye‐containing nanoparticles, [15] semiconducting polymer nanoparticles (SPNs) exhibit structural versatility for the design of activatable PA imaging probes [16] .…”

Section: Introductionmentioning

confidence: 99%

“…[10] Activatable PA imaging probes that only trigger the signals in the presence of specific molecular biomarkers offer measurable and quantifiable information on physiological and pathological status at the molecular level. [11] Among many PA agents including gold nanoparticles, [12] carbon-based nanomaterials, [13] hemicyanine, [14] and dye-containing nanoparticles, [15] semiconducting polymer nanoparticles (SPNs) exhibit structural versatility for the design of activatable PA imaging probes. [16] Till now, activatable PA probes have been extensively investigated for in vivo imaging of a variety of biologically active metabolites and disease-specific biomarkers, including aberrant pH, [17] ROS, [18] glutathione, [19] metal ions, [20] overexpression of enzymes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Activatable Polymeric Nanoprobe for Fluorescence and Photoacoustic Imaging of Tumor‐Associated Neutrophils in Cancer Immunotherapy

Zhang

et al. 2022

Angewandte Chemie

View full text Add to dashboard Cite

Imaging to evaluate tumor‐associated neutrophils (TANs) is imperative for cancer immunotherapy but remains challenging. We herein report an activatable semiconducting polymer nanoprobe (SPCy) for near‐infrared fluorescence (NIRF) and photoacoustic (PA) imaging of neutrophil elastase (NE), a biomarker of TANs. SPCy comprises a semiconducting polymer conjugated with a hemicyanine (hemi‐Cy) dye caged by a NE‐cleavable peptide as the side chain. After systemic administration, SPCy passively targets the tumor and reacts with NE to “uncage” the hemi‐Cy, leading to enhanced NIRF and PA signals of the hemi‐Cy but unchanged signals of the SP. Such NE‐activated ratiometric NIRF and enhanced PA signals of SPCy correlate with the intratumoral population of TANs. Thus, this study not only presents the first TAN‐specific PA probe, but also provides a general molecular design strategy for PA imaging of other immune‐related biomarkers to facilitate screening of cancer immunotherapeutics.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Activatable Polymeric Nanoprobe for Fluorescence and Photoacoustic Imaging of Tumor‐Associated Neutrophils in Cancer Immunotherapy

Zhang

et al. 2022

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

“…The selection processes and design considerations for targeted and activatable probes have been recently reviewed. 230 , 243 , 244 In this section, we will review some of the recent molecular PAI applications with PA probes.…”

Section: Molecular Photoacoustic Imagingmentioning

confidence: 99%

“…An extensive tutorial review by Zhao et al. 243 goes over common cancer biomarkers used for molecular imaging. Other exogenous probes specific to tumor-targeting are detailed in another recent review.…”

Section: Molecular Photoacoustic Imagingmentioning

confidence: 99%

Looking deep inside tissue with photoacoustic molecular probes: a review

2022

View full text Add to dashboard Cite

. Significance: Deep tissue noninvasive high-resolution imaging with light is challenging due to the high degree of light absorption and scattering in biological tissue. Photoacoustic imaging (PAI) can overcome some of the challenges of pure optical or ultrasound imaging to provide high-resolution deep tissue imaging. However, label-free PAI signals from light absorbing chromophores within the tissue are nonspecific. The use of exogeneous contrast agents (probes) not only enhances the imaging contrast (and imaging depth) but also increases the specificity of PAI by binding only to targeted molecules and often providing signals distinct from the background. Aim: We aim to review the current development and future progression of photoacoustic molecular probes/contrast agents. Approach: First, PAI and the need for using contrast agents are briefly introduced. Then, the recent development of contrast agents in terms of materials used to construct them is discussed. Then, various probes are discussed based on targeting mechanisms, in vivo molecular imaging applications, multimodal uses, and use in theranostic applications. Results: Material combinations are being used to develop highly specific contrast agents. In addition to passive accumulation, probes utilizing activation mechanisms show promise for greater controllability. Several probes also enable concurrent multimodal use with fluorescence, ultrasound, Raman, magnetic resonance imaging, and computed tomography. Finally, targeted probes are also shown to aid localized and molecularly specific photo-induced therapy. Conclusions: The development of contrast agents provides a promising prospect for increased contrast, higher imaging depth, and molecularly specific information. Of note are agents that allow for controlled activation, explore other optical windows, and enable multimodal use to overcome some of the shortcomings of label-free PAI.

show abstract

“…As such, the development of exogenous contrast agents has attracted enormous attention in PAI research in recent years [ 12 , 13 , 14 ]. Generally, a commendable contrast agent must have several features, including low quantum yield, high extinction coefficient, near-infrared (NIR) window peak absorption, great photostability, good target affinity, specificity, and biocompatibility [ 15 , 16 ]. Endogenous chromophores, including oxyhemoglobin, lipids and collagen, provide functional and anatomical information and exogenous contrast agents, from small molecular organic dyes to metallic nanomaterials, aid in cellular and molecular events in PAI [ 11 , 12 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Imaging Probes for Theranostic Applications

Zhu

Zhang

et al. 2022

Biosensors

View full text Add to dashboard Cite

Photoacoustic imaging (PAI), an emerging biomedical imaging technology, capitalizes on a wide range of endogenous chromophores and exogenous contrast agents to offer detailed information related to the functional and molecular content of diseased biological tissues. Compared with traditional imaging technologies, PAI offers outstanding advantages, such as a higher spatial resolution, deeper penetrability in biological tissues, and improved imaging contrast. Based on nanomaterials and small molecular organic dyes, a huge number of contrast agents have recently been developed as PAI probes for disease diagnosis and treatment. Herein, we report the recent advances in the development of nanomaterials and organic dye-based PAI probes. The current challenges in the field and future research directions for the designing and fabrication of PAI probes are proposed.

show abstract

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Abstract: Photoacoustic (PA) imaging can enable high resolution visualization of biological processes at the molecular level through the application of targeted contrast agents or activatable probes.

Cited by 80 publications

References 364 publications

An Activatable Polymeric Nanoprobe for Fluorescence and Photoacoustic Imaging of Tumor‐Associated Neutrophils in Cancer Immunotherapy

An Activatable Polymeric Nanoprobe for Fluorescence and Photoacoustic Imaging of Tumor‐Associated Neutrophils in Cancer Immunotherapy

Looking deep inside tissue with photoacoustic molecular probes: a review

Photoacoustic Imaging Probes for Theranostic Applications

Contact Info

Product

Resources

About