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Abstract

Liquid diet (LD) is known to be protective against indomethacin-induced enteropathy, which is thought to be associated with ischemic change. We tested the hypothesis that the solid component of diet modulates small intestinal blood flow (SIBF) following indomethacin administration. In the first experiment, male Wistar rats were divided into 18-hr-fasted and normal diet groups. Indomethacin (20 mg/kg) or vehicle was administered intracolonically. SIBF was measured on both the mesenteric and antimesenteric sides of the intestine, using the hydrogen gas clearance method. In the second experiment, rats were given LD alone or LD with increasing concentration of soluble/insoluble fiber for seven days. The baseline SIBF was significantly higher in the groups with normal diet and LD with fiber than in the fasting and LD groups. Following indomethacin administration, SIBF gradually decreased in the groups with normal diet and LD with insoluble fiber, while neither liquid diet nor fasting reduced SIBF. There was no difference in SIBF between the mesenteric and antimesenteric sides of the intestine in any group. Our findings suggest that solid components of diet increase basal SIBF and decrease SIBF following indomethacin administration.

Effect of anion channel antagonists and La on citrate release, Al content and Al resistance in maize roots

“…The mechanisms of the toxicity and resistance to aluminum have been widely studied (for reviews, see [2][3][4][5][6][7][8]). Although the toxic effects of aluminum have been recognized for 70 years, the reasons for this toxicity are still unknown.…”

Aluminium-induced phospholipid signal transduction pathway in Coffea arabica suspension cells and its amelioration by silicic acid

“…This toxic effect is not yet completely understood, in spite of the knowledge that Al-toxicity is involved with cell processes like inhibition of root elongation and cell division [55,56], nutrient-induced deficiency poor nutrient uptake [57], interaction with cytoskeleton [58] and inhibition on signal transduction events [12] among others. In the same sense it has been reported that Si can ameliorate Al-toxicity under certain conditions in species like barley (Hordeum vulgare; [59]), soybean (Glycine max; [60]), maize (Zea mays; [61]) and sorghum (Sorghum bicolor; [62]).…”

The location of aluminium in protoplasts and suspension cells taken from Coffea arabica L. with different tolerance of Al

“…It is never found naturally as a free metal but rather is always present as aluminium silicate or as a silicate of Al mixed with other metals such as sodium, potassium, iron, calcium or magnesium [4]. Aluminium toxicity is the most important growth-limiting factor for plants in highly acidic soils [5][6][7]. The cumulative data on Al-interactions indicates that Al has a significant effect on different signal transduction pathways such as phosphoinositide [8,9], protein phosphorylation [10] and polyamines [11,12], and that anion channels may participate in these interactions by excreting organic acids as an Al-tolerance mechanism in plants [13][14][15].…”