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Journal of Enzyme Inhibition and Medicinal Chemistry

Malik

et al. 2007

A novel series of complexes of the type [M(TML)X 2 ]; where TML is Tetradentate Macrocyclic Ligand; M ¼ Co(II), Ni(II), Cu(II), Zn(II)or Cd(II); X ¼ Cl 2 , CH 3 COO 2 or NO 2 3 have been synthesized by template condensation of glyoxal and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest a six coordinate octahedral geometry for these complexes. The low molar conductance values indicates them to be non-electrolytes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibitory potential.

Section: Chemistrysupporting

confidence: 63%

Template synthesis, spectroscopic studies and biological activities of macrocyclic complexes derived from thiocarbohydrazide and glyoxal

Journal of Enzyme Inhibition and Medicinal Chemistry

Malik

et al. 2007

“…Furthermore, no strong absorption band was observed near 1700 cm 1 , indicating the absence of >C=O of benzil and confirming the condensation of carbonyl groups of benzil and amino groups of thiocarbohydrazide [16,17]. These results provide strong evidence for the formation of the macrocyclic frame [18]. A strong absorption band in the region ca.…”

Section: Ir Spectramentioning

confidence: 55%

Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

Tyagi

2006

Transition Met Chem

A novel series of complexes of the type [M(TML)X 2 ]; where TML is a tetradentate macrocyclic ligand; M = Co(II), Ni(II), Cu(II) or Zn(II); X = Cl ) , CH 3 COO ) or NO 3 ) have been synthesized by template condensation of benzil and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized with the help of elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest the six coordinate octahedral geometry for these complexes. The low value of molar conductance indicates them to be non-electrolytes. The biological activities of metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential.

“…The disappearance of these bands and appearance of absorption band near ca. 1,590-1,610 cm )1 indicates the formation of macrocyclic Schiff's base [12,26] as these bands may be assigned due to m (C=N) [27,28]. The lower value of m(C=N) may be explained on the basis of a drift of lone pair density of azomethine nitrogen towards the metal atom [29,30] indicating that coordination takes place through nitrogen of C=N groups.…”

Section: Ir Spectramentioning

confidence: 99%

Synthesis and characterization of complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with macrocycle 3,4,11,12-tetraoxo-1,2,5,6,9,10,13,14-octaaza-cyclohexadeca-6,8,14,16-tetraene and their biological screening

Malik

et al. 2007

Transition Met Chem

114

A new series of complexes is synthesized by template condensation of glyoxal and oxalyldihydrazide in methanolic medium in the presence of divalent cobalt, nickel, copper, zinc and cadmium salts forming complexes of the type:3 ; OAc À1 . The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, n.m.r., infrared and far infrared spectral studies. On the basis of these studies, a six coordinate octahedral geometry for these complexes has been proposed. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Most of the compounds have been found to exhibit remarkable antibacterial activities.