ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

Endo, Akira; Kuroda, Masao; Tsujita, Yasuyuki

doi:10.7164/antibiotics.29.1346

Cited by 915 publications

(353 citation statements)

References 7 publications

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“…This effect was seen more clearly in the second S-phase peak of the two cell cycles studied, where the maximum HMG CoA reductase activity always preceded the S-phase burst (19,27,28). In preliminary studies it was shown that at a compactin concentration of 2.5 ,uM, sterol synthesis in the BHK-21 cell line was inhibited over a 1-hr period by at least 95%.…”

Section: Resultsmentioning

confidence: 91%

Essential role for mevalonate synthesis in DNA replication

Quesney-Huneeus

Wiley

Siperstein

1979

Proc. Natl. Acad. Sci. U.S.A.

262

122

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The relationship between 3-hydroxy-3-methylglutaryl (HMG) CoA hibitor compactin, the normal S-phase burst of DNA synthesis was specifically and totally prevented. Finally, the compactin-induced inhibition of DNA synthesis could be completely reversed within minutes by the addition of mevalonate, the product of the HMG CoA reductase reaction. By contrast, addition of cholesterol-rich lipoproteins had no effect upon DNA synthesis in compactin-treated cells. These data demonstrate that HMG CoA reductase activity, and therefore the production of mevalonate, plays an essential role in the synthesis of DNA specifically during the S phase of the cell cycle. Moreover, the results indicate that this function of mevalonate in regulating DNA replication is independent of its conversion to cholesterol.

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Section: Resultsmentioning

confidence: 91%

Essential role for mevalonate synthesis in DNA replication

Quesney-Huneeus

Wiley

Siperstein

1979

Proc. Natl. Acad. Sci. U.S.A.

262

122

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“…27 This first member of the group was isolated as an antibiotic product of P. brevicompactum. 28 At about the same time, it was found by Endo et al 29 as a cholesterolemic product of Penicillium citrinum. Although compactin was not of commercial importance, its derivatives achieved strong medical and commercial success.…”

Section: Anti-rejection Drugs (Agents That Suppress the Immune System)mentioning

confidence: 85%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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“…Hydroxymethylglutaryl-coenzyme A inhibitors (HMG-CoA inhibitors, or statins) were initially identified as fungal extracts in 1976 (1). They were subsequently developed as cholesterol-lowering drugs, and have been shown in numerous clinical trials to reduce both cardiovascular morbidity and mortality (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%