Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses

Björvang, Richelle D.; Vinnars, Marie Therese; Papadogiannakis, Nikos; Gidlöf, Sebastian; Mamsen, Linn Salto; Mucs, Dániel; Kiviranta, Hannu; Rantakokko, Panu; Ruokojärvi, Päivi; Lindh, Christian; Andersen, Claus Yding; Damdimopoulou, Pauliina

doi:10.1016/j.chemosphere.2021.131125

Cited by 30 publications

(19 citation statements)

References 54 publications

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“…3a). In our earlier study on human fetuses, we observed a similar trend for transfer efficiency from mother to the child (Björvang et al, 2021b). To know whether passive diffusion could explain this behavior, we assessed the correlation of the FF:blood ratio with logKow, a measure of lipophilicity of chemicals.…”

Section: Chemical Group and Age Affects Chemical Transfer From Blood ...mentioning

confidence: 77%

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Björvang

Hallberg

Pikki

et al. 2022

Environmental Research

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Section: Chemical Group and Age Affects Chemical Transfer From Blood ...mentioning

confidence: 77%

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Björvang

Hallberg

Pikki

et al. 2022

Environmental Research

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“…The oral route was selected to model human exposures to EDCs, which often occur via the diet. We note the caveat that we did not measure concentrations of chemicals in the dam or transfer to the embryos; however, such transfer is likely to have happened based on robust evidence for transplacental transfer of EDCs, and presence of chemicals in amniotic fluid, fetal tissues, and umbilical cord blood [ 44 , 45 , 46 , 47 ]. Appropriate personal protective equipment was used when handling the chemicals.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats

Gore

Moore

Groom

et al. 2022

Toxics

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Humans and wildlife are exposed to endocrine-disrupting chemicals (EDCs) throughout their lives. Environmental EDCs are implicated in a range of diseases/disorders with developmental origins, including neurodevelopment and behavior. EDCs are most often studied one by one; here, we assessed outcomes induced by a mixture designed to represent the real-world situation of multiple simultaneous exposures. The choice of EDCs, which we refer to as “NeuroMix,” was informed by evidence for neurobiological effects in single-compound studies and included bisphenols, phthalates, vinclozolin, and perfluorinated, polybrominated, and polychlorinated compounds. Pregnant Sprague Dawley rats were fed the NeuroMix or vehicle, and then offspring of both sexes were assessed for effects on postnatal development and behaviors and gene expression in the brain in adulthood. In order to determine whether early-life EDCs predisposed to subsequent vulnerability to postnatal life challenges, a subset of rats were also given a stress challenge in adolescence. Prenatal NeuroMix exposure decreased body weight and delayed puberty in males but not females. In adulthood, NeuroMix caused changes in anxiety-like, social, and mate preference behaviors only in females. Effects of stress were predominantly observed in males. Several interactions of NeuroMix and stress were found, especially for the mate preference behavior and gene expression in the brain. These findings provide novel insights into how two realistic environmental challenges lead to developmental and neurobehavioral deficits, both alone and in combination, in a sex-specific manner.

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“…The primary route of exposure to POPs in humans is through ingestion, inhalation and absorption ( Bergman et al, 2013 ; Gore et al, 2015 ). Further exposure occurs through placental transfer from mother to the fetus ( Mamsen et al, 2017 , 2019 ; Björvang et al, 2021 ), and after birth through breastfeeding ( Krysiak-Baltyn et al, 2010 ). Because POPs are found almost everywhere, exposure of the next generation starts even before conception.…”

Section: Introductionmentioning

confidence: 99%

“…Because POPs are found almost everywhere, exposure of the next generation starts even before conception. Studies have shown that human oocytes are extensively exposed to mixtures of these chemicals ( Björvang and Damdimopoulou, 2020 ; Björvang et al, 2021 ; Lefebvre et al, 2021 ). Several studies have also found POPs to have a negative effect on human spermatogenesis, though the pathophysiological mechanisms are not fully elucidated ( Toft et al, 2012 ; Sharma et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Since it is not possible to acquire fetal tissues in birth cohorts, there are only a limited number of studies with the unique opportunity to analyze the actual chemical concentrations in human fetal tissues. The available data are from fetal tissues obtained either from elective pregnancy terminations or stillbirths ( Curley et al, 1969 ; Nishimura et al, 1977 ; Schecter et al, 2006 ; Doucet et al, 2009 ; Pusiol et al, 2016 ; Mamsen et al, 2017 , 2019 ; Zota et al, 2018 ; Björvang et al, 2021 ). Among these nine studies, only three investigated the sexual dimorphism of POP exposure ( Nishimura et al, 1977 ; Mamsen et al, 2019 ; Björvang et al, 2021 ) while Zota and colleagues (2018) only adjusted for fetal sex when looking into the association between fetal liver PBDEs and fetal cytochrome P450 gene expression.…”

Section: Introductionmentioning

confidence: 99%

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Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses

Björvang

Mamsen

2022

Front. Toxicol.

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Living in an industrialized era, we are exposed to man-made chemicals including persistent organic pollutants (POPs). Previous studies have shown associations of POP exposure with adverse outcomes in humans, wildlife, and the environment, making it a global concern. Exposure during sensitive windows of susceptibility such as fetal development is of particular concern because of the potential increased risk of developing diseases in childhood and adulthood. However, there are limited studies on the sexual dimorphism of POP accumulation during the prenatal period. In this mini-review, we focus on differences in POP concentrations in the placenta and fetal tissues between males and females. We also show the sexually dimorphic adverse outcomes of prenatal exposure to POPs. Overall, our summary shows that males may accumulate higher concentrations of POPs in the placenta and fetal tissues compared to females, although studies are sparse and inconsistent. In addition, there are differences in adverse health outcomes associated to prenatal POP exposure according to sex. Hence, we highly urge researchers investigating the health effects of POP exposure to consider sexual dimorphism in their studies.

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Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses

Cited by 30 publications

References 54 publications

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats

Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses

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