Mixture of vitamin C, hesperidin and piperidol exposure in pregnancy: maternal-fetal repercussions

Volpato, Gustavo Tadeu; Damasceno, Débora Cristina; Miranda, Márcia Regina F.; Filho, Daher Sabbag; Calderon, Iracema de Mattos Paranhos; Rudge, Marilza Vieira Cunha

doi:10.1590/s1516-93322006000100008

Rev. Bras. Cienc. Farm.

2006

DOI: 10.1590/s1516-93322006000100008

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Mixture of vitamin C, hesperidin and piperidol exposure in pregnancy: maternal-fetal repercussions

Gustavo Tadeu Volpato

Débora Cristina Damasceno

Márcia Regina F. Miranda

et al.

Abstract: To evaluate the reproductive performance and the development of their offspring on rat pregnancy, Wistar pregnant rats were gavaged with 0 mg/kg wb/day (control group, n = 20)

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“…Those whose weights were at least 1.0 SD greater than the G1 mean birth weight were classified as large for gestational age. Those whose birth weights were at least 1.0 SD lower than the G1 mean birth weight were classified as small for gestational age (8).…”

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Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

Rudge

Damasceno

Volpato

et al. 2007

Braz J Med Biol Res

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The aim of the present study was to evaluate the effect of Ginkgo biloba treatment (EGb 761, 200 mg kg -1 day -1 ) administered from day 0 to 20 of pregnancy on maternal reproductive performance and on the maternal and fetal liver antioxidant systems of streptozotocin-induced diabetic Wistar rats. On day 21 of pregnancy, the adult rats (weighing approximately 250 ± 50 g, minimum number = 13/group) were anesthetized to obtain maternal and fetal liver samples for superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and total glutathione (GSH-t) determinations. The uterus was weighed with its contents. The diabetic (G3) and treated diabetic (G4) groups of rats presented significant maternal hyperglycemia, reduced term pregnancy rate, impaired maternal reproductive outcome and fetal-placental development, decreased GSH-Px (G3 = G4 = 0.6 ± 0.2) and SOD (G3 = 223.0 ± 84.7; G4 = 146.1 ± 40.8), and decreased fetal CAT activity (G3 = 22.4 ± 10.6; G4 = 34.4 ± 14.1) and GSH-t (G3 = G4 = 0.3 ± 0.2), compared to the non-diabetic groups (G1, untreated control; G2, treated). For G1, maternal GSH-Px = 0.9 ± 0.2 and SOD = 274.1 ± 80.3; fetal CAT = 92.6 ± 82.7 and GSH-t = 0.6 ± 0.5. For G2, G. biloba treatment caused no toxicity and did not modify maternal or fetal-placental data. EGb 761 at the nontoxic dose used (200 mg kg -1 day -1 ), failed to modify the diabetes-associated increase in maternal glycemia, decrease in pregnancy rate, decrease in antioxidant enzymes, and impaired fetal development when the rats were treated throughout pregnancy (21 days).

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mentioning

confidence: 99%

Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

Rudge

Damasceno

Volpato

et al. 2007

Braz J Med Biol Res

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Mixture of vitamin C, hesperidin and piperidol exposure in pregnancy: maternal-fetal repercussions

Abstract: To evaluate the reproductive performance and the development of their offspring on rat pregnancy, Wistar pregnant rats were gavaged with 0 mg/kg wb/day (control group, n = 20)

Cited by 1 publication

References 4 publications

Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

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