Mixing Performance of a Passive Micro-Mixer with Mixing Units Stacked in Cross Flow Direction

Juraeva, Makhsuda; Kang, Dong‐Jin

doi:10.3390/mi12121530

Cited by 15 publications

(9 citation statements)

References 50 publications

(75 reference statements)

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“…The fluid was considered incompressible and Newtonian, with a density of 10 3 kg/m 3 , a dynamic viscosity of 10 –3 Pa·s, and a diffusion coefficient of 10 –9 m 2 /s, as common reference values in micromixer studies. − Also, the steady-state condition was selected to evaluate the numerical simulations. Equal uniform velocity was set to both of the inlets, along with applying the molar concentrations (mol/m 3 ) of 0 and 1 to inlet 1 and inlet 2, respectively.…”

Section: Methodsmentioning

confidence: 99%

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

Hazeri,

Abouei Mehrizi,

Mohseni

et al. 2023

Ind. Eng. Chem. Res.

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Most biorelated applications require homogeneous mixing, necessitating innovative approaches to design high-efficiency micromixers. In this study, for the first time, we have changed the straight structure of a base square-wave micromixer to include regularpolygon-designed mixing units coupled with convergent−divergent channels. The aim was to show that the designed mixing units can enhance mixing at low Reynolds (Re) numbers. Importantly, within the optimization process, the mixing volume and mixing length of the micromixers were kept intact. In this respect, the required numerical evaluations were conducted to obtain the optimized micromixers at Re = 0.1 and 2, where the mixing index for the base micromixer increased from 0.9187 to 0.9944 and from 0.1600 to 0.4043, respectively. Finally, to prove that the optimized micromixers possess a better practical performance than the base micromixer, RBC lysis, as a vital preprocessing step of many biological experiments, was compared at Re = 0.1 and 2 for the base and optimized micromixers.

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Section: Methodsmentioning

confidence: 99%

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

Hazeri,

Abouei Mehrizi,

Mohseni

et al. 2023

Ind. Eng. Chem. Res.

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“…Liu et al [ 30 ] proposed a 3D cross-linked double-helix micromixer, studied the fast mixing process under a low Re number by using a numerical method, and found that mixing units such as split recombination, chaotic advection and flow impact could improve mixing efficiency in the microchannel. Juraeva et al [ 31 ] proposed a passive micromixer stacked with eight mixing cells, in which each mixing cell was provided with a baffle to make the fluid disturbance in the channel stronger and the mixing efficiency higher. Xia et al [ 32 ] proposed a chaotic mixer with a gap and a baffle structure.…”

Section: Introductionmentioning

confidence: 99%

Influence of Structural Parameters on the Performance of an Asymmetric Rhombus Micromixer with Baffles

Nai

Zhang

et al. 2023

Micromachines

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As an important part of lab−on−a−chip and micro−total analysis systems, micromixers have a wide range of applications in biochemical analysis, pharmaceutical preparation and material synthesis. In the work, a novel rhombic separation and recombination micromixer with baffles was presented to further improve the performance of the micromixer and study the effect of multiple structural parameters on mixing. The effects of the rhombic angle, the width ratio of sub−channel and the size and relative positions of baffles on the mixing index were studied numerically at different Reynolds numbers (Re), and the sensitivity of the mixing index to various structures was also investigated. The results showed that the mixing index increased with the subchannel’s width ratio and slowly decreased after reaching the peak value in the range of Re from 0.1 to 60. The maximum mixing index appeared when the width ratio was 6.5. The pressure drops in the microchannel were proportional to the width ratio. The mixing effect can be further improved by adding baffle structure to asymmetric rhombus micromixer, and more baffle quantity and larger baffle height were beneficial to the improvement of the mixing index. The research results can provide reference and new ideas for the structure design of passive micromixers.

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“…In contrast, passive micromixers use geometric structures to generate chaotic fluid flow without any moving parts, making them simpler, less expensive, and more cost-effective to integrate into various microfluidic systems. Various geometric structures and modifications, such as twisting of the micromixer wall [ 12 ], a staggered herringbone design [ 13 ], blockage in the junction of the fluid stream [ 14 ], surface grooves and baffles [ 15 , 16 ], split-and-recombine (SAR) units [ 17 , 18 ], Tesla structure [ 19 , 20 ], stacking of the mixing units in the cross-flow direction [ 21 ], stacking in the lateral direction [ 22 ] and submergence of the mixing unit [ 23 ], have been studied to generate chaotic flow fields. However, most passive micromixers only show effective mixing in a limited range of Reynolds numbers.…”

Section: Introductionmentioning

confidence: 99%

Mixing Performance of a Passive Micromixer Based on Multiple Baffles and Submergence Scheme

Juraeva

Kang

2023

Micromachines

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A novel passive micromixer based on multiple baffles and a submergence scheme was designed, and its mixing performance was simulated over a wide range of Reynolds numbers ranging from 0.1 to 80. The degree of mixing (DOM) at the outlet and the pressure drop between the inlets and outlet were used to assess the mixing performance of the present micromixer. The mixing performance of the present micromixer showed a significant enhancement over a wide range of Reynolds numbers (0.1 ≤ Re ≤ 80). The DOM was further enhanced by using a specific submergence scheme. At low Reynolds numbers (Re < 5), submergence scheme Sub24 produced the highest DOM, approximately 0.57, which was 1.38 times higher than the case with no submergence. This enhancement was due to the fluid flowing from or toward the submerged space, creating strong upward or downward flow at the cross-section. At high Reynolds numbers (Re > 10), the DOM of Sub1234 became the highest, reaching approximately 0.93 for Re = 20, which was 2.75 times higher than the case with no submergence. This enhancement was caused by a large vortex formed across the whole cross-section, causing vigorous mixing between the two fluids. The large vortex dragged the interface between the two fluids along the vortex perimeter, elongating the interface. The amount of submergence was optimized in terms of DOM, and it was independent of the number of mixing units. The optimum submergence values were 90 μm for Sub24 and Re = 1, 100 μm for Sub234 and Re = 5, and 70 μm for Sub1234 and Re = 20.

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Mixing Performance of a Passive Micro-Mixer with Mixing Units Stacked in Cross Flow Direction

Cited by 15 publications

References 50 publications

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

Influence of Structural Parameters on the Performance of an Asymmetric Rhombus Micromixer with Baffles

Mixing Performance of a Passive Micromixer Based on Multiple Baffles and Submergence Scheme

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