In this review, we discuss some interesting issues in charm physics, which is full of puzzles and challenges. So far in this field, there exist many problems which have not obtained satisfactory answers yet as more unexpected phenomena Continue to be observed at the current facilities of high energy physics. Charm physics may become an ideal place for searching new resonances and studying non-perturbative QCD effects, moreover it is probably an area for exploring new physics beyond the Standard Model. More data will be available at the BE-SIII, B-factories, LHC and even the future ILC, which may open a wide window to a better understanding of its nature.