Mixing of Injectable Fillers: A National Survey

Libby, Tiffany J.; Williams, Ramone F.; Habr, Constantin El; Tinklepaugh, Adam; Ciocon, David H.

doi:10.1097/dss.0000000000001631

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…Although there are no current recommendations or guidelines to mix fillers with other solutions, physicians report mixing fillers to decrease viscosity to facilitate easier injections. 35 Bacteriostatic saline may be preferred to normal saline. CaHA is highly viscoelastic.…”

Section: Combination Ha Fillers With Agarose Gel or Mixing With Other...mentioning

confidence: 99%

“…Some solutions that are premixed before injection include plain lidocaine (44%), lidocaine with epinephrine (36%), normal saline (30%), and sterile water (7%). Although there are no current recommendations or guidelines to mix fillers with other solutions, physicians report mixing fillers to decrease viscosity to facilitate easier injections 35 . Bacteriostatic saline may be preferred to normal saline.…”

Section: Puragen and Puragen Plusmentioning

confidence: 99%

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Other hyaluronic acid fillers and combination fillers

Lee,

Hebel,

Snyder

et al. 2023

Dermatological Reviews

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The use of hyaluronic acid (HA) fillers has become increasingly popular in the cosmetic industry due to their efficacy and versatility. Common types of HA fillers include Restylane, Juvéderm, and Bolotero. Other various options available for HA fillers include the resilient HA fillers (RHA) collection, Revanesse versa, and Prevelle silk. The fillers can be used singularly or in combination to achieve a desired cosmetic outcome. The RHA collection line is the first FDA approved filler used to treat dynamic facial lines using a less rigid formula than earlier HA fillers and by uniquely adapting to facial movement, stretching, and repeated facial compression. Revanesse versa filler is designed to effectively address moderate to severe facial wrinkles, including nasolabial folds, with a focus on providing lasting results even after the HA filler has been absorbed. Other HA fillers such as Prevelle silk, Hydrelle, and Puragen contain 0.3% lidocaine for more tolerable treatment for moderate to severe facial lines. Examples of combination fillers include HA/botulinum toxin, HA/calcium hydroxyapatite (CaHA), and HA/poly‐ l‐lactic acid. To facilitate the administration of injections, HA fillers can also be mixed with agents such as lidocaine, lidocaine and epinephrine, normal saline, and sterile water to decrease viscosity. Furthermore, the use of CaHA in conjunction with microfocused ultrasound with visualization (MFU‐V) has shown to enhance skin tightness and neocollagenesis. Other applications of HA include utilization of its bacteriostatic effects to coat biomedical devices, as a material for bioink and tissue‐engineering, and to create novel formulations to further personalize cosmetic goals.

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Section: Combination Ha Fillers With Agarose Gel or Mixing With Other...mentioning

confidence: 99%

Section: Puragen and Puragen Plusmentioning

confidence: 99%

Other hyaluronic acid fillers and combination fillers

Lee,

Hebel,

Snyder

et al. 2023

Dermatological Reviews

View full text Add to dashboard Cite

show abstract

“…[13] Tweaking the fillers by diluting them with saline or anesthetic so as to reduce lumpiness and reduce viscosity has been in practice by a large number of injectors. [14,15] Recently, polyethylene glycol diglycidyl ether (PEGDE) as a crosslinker for HA has been used instead of 1,4 butanediol diglycidyl ether (BDDE) to change the physiochemical properties of the filler to improve longevity. [16]…”

Section: Newer Filler Materials and Filler-tissue Interactionsmentioning

confidence: 99%

Fillers for aesthetics on the face – Newer perspectives

Arora¹

2021

CSDM

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Dermal fillers are a cornerstone of the aesthetic treatments of the face. They have evolved over many aspects since their initial use. Facial fillers are not just used for anti-aging to restore volume, but are now also used for contouring, enhancing facial features, and changing the emotional attributes of the face. Newer techniques and approaches have been proposed for greater predictability of results and minimum complications. Newer composite filler materials and a resurgence of older materials have taken place with better understanding of the science behind them. With more use of facial fillers comes the reporting of newer complications with recommendations and guidelines to avoid them. A new perspective is seen in guidelines for their use in the COVID-19 pandemic. This article is a review of the insight into the latest perspectives of facial fillers for aesthetic indications.

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Combining Calcium Hydroxylapatite and Hyaluronic Acid Fillers for Aesthetic Indications: Efficacy of an Innovative Hybrid Filler

Fakih-Gomez

Kadouch²

2021

Aesth Plast Surg

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Background Limited data are available describing effectiveness of combining the use of calcium hydroxylapatite (CaHA) and hyaluronic acid (HA). Methods The authors performed a retrospective chart review of patients injected with a premixed combination of CaHA and a cohesive polydensified matrix (CPM®) HA (CaHA:CPM-HA ) in the authors’ aesthetic practices. The midface and lower face were injected. Patients’ records were evaluated, and treatment results were scored using the Merz Aesthetics Scale for the jawline® (clinician rated, CR-MASJ). Adverse events were recorded. Results A total of 41 patients were included, all females with a mean age of 47.5 years (range 21–63 years). The mean CR-MASJ score improved from 2.12 at baseline to 0.68 at t = 3 months (SD = 0.69, 95% CI 1.28–1.60) and 1.27 at t = 12 months (SD = 0.74, 95% CI 0.43–0.74). 100% of the subjects had experienced a ≥1-point improvement in CR-MASJ score at t = 3 months, versus 85% at t = 12 months. No adverse events were reported. Conclusion The results of this study support the volumizing and lifting potential of the hybrid mix CaHA:CPM-HA for treatment of cheeks and jawline. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Mixing of Injectable Fillers: A National Survey

Cited by 8 publications

References 9 publications

Other hyaluronic acid fillers and combination fillers

Other hyaluronic acid fillers and combination fillers

Fillers for aesthetics on the face – Newer perspectives

Combining Calcium Hydroxylapatite and Hyaluronic Acid Fillers for Aesthetic Indications: Efficacy of an Innovative Hybrid Filler

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