-In this study, an ore taken from Kayseri region of Turkey was used. Characterization studies showed that the run-of mine ore is rich in oxide minerals, cerussite (PbCO 3 ) and smithsonite (ZnCO 3 ). The aim of the study was extraction of zinc from smithsonite by ammonia leaching on cerussite flotation tailings. Initial lead and zinc grades of the ore were 13.31% and 27.86%, respectively. As a result of a series of cerussite flotation tests, a lead concentrate containing 63.25% Pb was produced with 82.76% recovery. After that, tailing of flotation was treated with ammonia (NH 3 ) to extract zinc. For that purpose, 5M and 7M of NH 3 solutions were used for 30 minutes, 1 hour, 3 hours, 6 hours and 12 hours. In consequence of the leaching experiments, the highest extraction rate was obtained as 76.66% using 7M NH 3 solution with 12 hours of treatment.