2023
DOI: 10.1016/j.molstruc.2023.134986
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Mixed-ligand copper(II) hydrazone complexes: Synthesis, structure, and anti-lung cancer properties

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Cited by 9 publications
(4 citation statements)
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“…More recently, Guo and coworkers also reported similar strategy, i.e. mixed-ligand hydrazone based copper(II) complexes and examined their potential anti-lung cancer activity (Figure 23) [53]. Results of this study revealed that the investigated mixedligand copper(II) complexes especially the complex with furan pendant was found playing a good role in inducing ROS-mediated mitochondrial pathway regulated A549 cancer cell apoptosis.…”
Section: Proposed Schematic Structural Representation Of the Metal Co...mentioning
confidence: 67%
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“…More recently, Guo and coworkers also reported similar strategy, i.e. mixed-ligand hydrazone based copper(II) complexes and examined their potential anti-lung cancer activity (Figure 23) [53]. Results of this study revealed that the investigated mixedligand copper(II) complexes especially the complex with furan pendant was found playing a good role in inducing ROS-mediated mitochondrial pathway regulated A549 cancer cell apoptosis.…”
Section: Proposed Schematic Structural Representation Of the Metal Co...mentioning
confidence: 67%
“…Therefore, due to the vast literature report on hydrazone-based copper(II) complexes, only selected representative works are discussed in detail. From the above seminal representative works discussed, it is interesting to note that similar to the azo-based copper(II) Single crystal structure of the copper(II) complex and its schematic illustration of ROS-mediated mitochondrial pathway regulated A549 cancer cell apoptosis; (top) the 3D morphological changes on the A549 cells treated with the complex for 6 days with scale bar: 200 μm (middle) and wound healing results exhibited by the complex through inhibition of the A549 cells migration where pictures with scale bar: 200 μm taken at 0 h as well as 24 h, respectively (bottom) [ 53 ].…”
Section: Proposed Schematic Structural Representation Of the Metal Co...mentioning
confidence: 99%
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“…Their unique structural characteristics, coupled with the ability to modulate their electronic and steric properties through functional group substitution, make hydrazine particularly intriguing candidates for metal complexation (Saeed et al, 2016; . In this paper, the coordination ability of t h e n o v e l l i g a n d s ; b e n z y l a c e t o n ebenzoylhydrazone and its para-hydroxyl and paranitro substituted analogues with copper(II) metal salts bearing various counter anions were explored with a view to understanding their chemistry, since Meira, et al, 2018) it is known from literature that copper(II) complexes do exhibit distinctive structural features and electronic properties, which are influenced by the nature of the substituents on the hydrazone ligands (Kendel et al, 2020;Wu et al, 2023). Their antibacterial activity was also investigated since hydrazones and their metal complexes are known to exhibit antimicrobial activities.…”
Section: Introductionmentioning
confidence: 99%