Mixed-ligand copper(II) hydrazone complexes: Synthesis, structure, and anti-lung cancer properties

Novel Synthesis of N–N Azo and Hydrazine Phenyl Ligand Derivatives for Copper(II) Complex Bio-Active Application

“…More recently, Guo and coworkers also reported similar strategy, i.e. mixed-ligand hydrazone based copper(II) complexes and examined their potential anti-lung cancer activity (Figure 23) [53]. Results of this study revealed that the investigated mixedligand copper(II) complexes especially the complex with furan pendant was found playing a good role in inducing ROS-mediated mitochondrial pathway regulated A549 cancer cell apoptosis.…”

“…Therefore, due to the vast literature report on hydrazone-based copper(II) complexes, only selected representative works are discussed in detail. From the above seminal representative works discussed, it is interesting to note that similar to the azo-based copper(II) Single crystal structure of the copper(II) complex and its schematic illustration of ROS-mediated mitochondrial pathway regulated A549 cancer cell apoptosis; (top) the 3D morphological changes on the A549 cells treated with the complex for 6 days with scale bar: 200 μm (middle) and wound healing results exhibited by the complex through inhibition of the A549 cells migration where pictures with scale bar: 200 μm taken at 0 h as well as 24 h, respectively (bottom) [ 53 ].…”

“…Figure 23. Single crystal structure of the copper(II) complex and its schematic illustration of ROS-mediated mitochondrial pathway regulated A549 cancer cell apoptosis; (top) the 3D morphological changes on the A549 cells treated withthe complex for 6 days with scale bar: 200 μm (middle) and wound healing results exhibited by the complex through inhibition of the A549 cells migration where pictures with scale bar: 200 μm taken at 0 h as well as 24 h, respectively (bottom)[ 53 ].…”

Synthesis, characterisation and antibacterial study of copper(ii) complexes of new benzylacetone-benzoylhydrazone and its <i>para</i>-nitro and <i>para</i>-hydroxy substituted analogues

“…Their unique structural characteristics, coupled with the ability to modulate their electronic and steric properties through functional group substitution, make hydrazine particularly intriguing candidates for metal complexation (Saeed et al, 2016; . In this paper, the coordination ability of t h e n o v e l l i g a n d s ; b e n z y l a c e t o n ebenzoylhydrazone and its para-hydroxyl and paranitro substituted analogues with copper(II) metal salts bearing various counter anions were explored with a view to understanding their chemistry, since Meira, et al, 2018) it is known from literature that copper(II) complexes do exhibit distinctive structural features and electronic properties, which are influenced by the nature of the substituents on the hydrazone ligands (Kendel et al, 2020;Wu et al, 2023). Their antibacterial activity was also investigated since hydrazones and their metal complexes are known to exhibit antimicrobial activities.…”