Novel Synthesis of N–N Azo and Hydrazine Phenyl Ligand Derivatives for Copper(II) Complex Bio-Active Application

Abstract

Copper(II) complexes possess relatively a broad spectrum of medicinal importance with less toxicity. It is important to note that, in this chapter, copper(II) is selected as chelating central metal atom considering its current reputation to design such bio-active compounds due to its; (i) permits in realizing stable coordination compound, (ii) diverse coordinating capability with oxygen (O), nitrogen (N), sulfur (S) and phosphorus (P) donor ligands, and (iii) exhibits potentially better biological activity. Therefore, the presented chapter offers the up-to-date advancement and future perspective of bio-active copper(II) complexes derived from Schiff base of azo- and phenyl hydrazine-based ligands and their derivatives. To showcase the existing trend of these classes of bio-active compounds, due to the wide depth of the literature, selected seminal compounds exhibiting outstanding biological activity are discussed in detail. Recent studies establish that azo- and phenyl hydrazine-based bio-active copper(II) complexes are among the promising candidates that are expected to replace the conventional antibiotics which are suffering from side effects as well as microbial resistance. However, the collaborative efforts of chemists and biotechnologists are still needed to realize their real world application.