Mixed Infection of African Green Monkey Kidney Cells by Adenovirus 7 and SV 40

Defective Dna Animal Viruses

“…presence of simian papovavirus SV40 increased the yield of adenovirus 12 from infected green monkey kidney cells. Although the conclusions were based primarily on morphologic evidence, the investigators suggested that the human virus was defective in the simian cells (49)(50)(51)(52)(53). A series of quantitative experiments subsequently confirmed this conclusion and at tempted to delineate the nature of the defect which was responsible for the abortive infection.…”

“…These include the simian papovavirus SV 40 (49)(50)(51)(52)(53)(54)(62)(63)(64)(65)(66)(67)(68), defective SV40 [ (68)(69)(70), also see Papovavirus section], the defective monkey cell-adapting component (71), and simian adenoviruses (72,73). Other viruses, such as herpes simplex virus and measles virus, were inef fective as helpers (S4).…”