Mixed Germ Cell Tumor with Embryonal Carcinoma, Choriocarcinoma, and Epithelioid Trophoblastic Tumor in the Ovary of a Cynomolgus Monkey

Yokouchi, Yusuke; Imaoka, Masako; Sayama, Ayako; Sanbuissho, Atsushi

doi:10.1177/0192623311399787

Cited by 9 publications

(11 citation statements)

References 17 publications

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“…In this case, the immunohistochemical findings in the mesometrium were similar to findings reported on typical simian choriocarcinoma cells, as shown in the immunohistochemistry for CK7, hCG and α-inhibin [13]. However, the finding that not all the tumor cells in the mesometrium were positive for hCG suggests that a limited number of invasive tumor cells have choricarcinomatous features.…”

supporting

confidence: 87%

“…The diagnosis of a choriocarcinoma-like component necessitates demonstration of trophoblastic differentiated cells, which generally express chorionic gonadotropin [2, 3, 7, 13]. In this case, the immunohistochemical findings in the mesometrium were similar to findings reported on typical simian choriocarcinoma cells, as shown in the immunohistochemistry for CK7, hCG and α-inhibin [13].…”

supporting

confidence: 70%

“…Another unexplainable finding is that several pleomorphic tumor cells were also positive for AFP, which is a crucial marker for embryonal carcinomas and yolk sac tumors [11]. This case might have an embryonic feature in part; however, we ruled out embryonal carcinoma as a diagnosis, because there was a lack of sheets, glands and a papillary growth pattern of embryonic (primitive) epithelial cells [11, 13]. …”

mentioning

confidence: 99%

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Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat

Kawashima

Segawa

Yoshida

et al. 2017

The Journal of Veterinary Medical Science

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An 11-year-old female goat had invasive and metastatic endometrial adenocarcinoma in the uterus. There was a notable proliferation of endometrial epithelial cells in a tubular growth pattern, with a desmoplastic response. The endometrial epithelial tumor cells metastasized to the kidney, liver and lung. In contrast to the primary and metastatic tumor cells, pleomorphic tumor cells with a choriocarcinoma-like growth pattern infiltrated the mesometrium. Cell proliferation activity was high in both types of tumor cells. Both types of tumor cells expressed cytokeratins AE1/AE3, 7 and CAM5.2; choriocarcinomatous cells also had positive immunoreactions to human chorionic gonadotropin, human placental alkaline phosphatase and α-inhibin. The present case was diagnosed as endometrial adenocarcinoma with choriocarcinomatous differentiation.

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supporting

confidence: 87%

supporting

confidence: 70%

mentioning

confidence: 99%

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Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat

Kawashima

Segawa

Yoshida

et al. 2017

The Journal of Veterinary Medical Science

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“…17 In addition, nongestational PSTT and ETT have been reported in nonhuman primates. [18][19][20] Although teratomatous elements were not identified in the nongestational ETT in our series, it is possible that such elements were not found due to sampling issues or possible overgrowth of a teratomatous component. Regardless, genotyping established that the tumor was nongestational.…”

Section: Discussionmentioning

confidence: 71%

Ovarian Intermediate Trophoblastic Tumors

Xing¹,

Zhong

et al. 2019

American Journal of Surgical Pathology

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Trophoblastic neoplasms involving the ovary are uncommon and include gestational tumors, which are either metastatic from the uterus or ectopic and nongestational tumors, which include those of germ cell type/origin and somatic tumors with trophoblastic differentiation; in all these types, most are pure choriocarcinoma. Intermediate trophoblastic tumors, which include placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT), are rare in the ovary, with most assumed to be gestational; this is the only category formally recognized in 2014 World Health Organization (WHO) classification, likely due to few well-documented nongestational examples. We report the clinicopathologic features of 6 ovarian intermediate trophoblastic tumors, including 3 PSTTs, 2 ETTs, and 1 ETT with choriocarcinomatous differentiation. DNA-based short tandem repeat genotyping identified 4 of these as nongestational (3 PSTTs and 1 ETT), as evidenced by sharing of alleles between tumor and normal tissue at all informative loci. Interestingly, all 3 of the nongestational PSTTs coexisted with mature cystic teratoma. The remaining 2 tumors (1 ETT and 1 ETT with some choriocarcinomatous differentiation) were gestational (likely ectopic due to lack of evidence of a uterine tumor), as evidenced by the presence of both maternal and novel/nonmaternal alleles at informative loci in tumor compared with normal tissue. It is important to recognize a distinct category of primary ovarian nongestational intermediate trophoblastic tumors of germ cell type/origin, including PSTT and ETT, in classification systems to guide clinical management, as gestational and nongestational tumors have different genetic origins and may require different therapy. Genotyping is useful for classification as nongestational versus gestational, particularly as traditional clinicopathologic findings cannot always predict the nature of a trophoblastic tumor.

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“…Trophoblastic tumors are rare neoplasms in domestic and laboratory animal species, and in non-human primates have been reported in the uterus and ovary (Chu et al 2007; Cooper et al 2005; Farman et al 2005; Giusti et al 2005; Marbaix et al 2008; Marr-Belvin et al 2010; Toyosawa et al 2000; Yokouchi et al 2011) In humans, most occur following a normal or ectopic pregnancy, abortion, or molar pregnancy (Bentley 2003; Hui et al 2014). These are comprised of placental site trophoblastic tumors (PSTTs), epithelioid trophoblastic tumors (ETTs), and choriocarcinomas (CC).…”

Section: Reproductive Lesion In a Rhesus Macaquementioning

confidence: 99%

Proceedings of the 2018 National Toxicology Program Satellite Symposium

et al. 2018

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The 2018 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Indianapolis, Indiana at the Society of Toxicologic Pathology’s 37th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were used by the audience for voting and discussion. Various lesions and other topics covered during the symposium included seminiferous tubule dysgenesis in rats, ameloblast and odontoblast degeneration/necrosis in an SD rat, intestinal leiomyositis in a beagle dog, gallbladder mucinous hyperplasia, focus of hepatocellular alteration and bile duct alteration in otters, renal tubule cytoplasmic vacuolation with basophilic granules in mice treated with antisense oligonucleotide therapy, a uterine choriocarcinoma in a rhesus macaque and rete ovarii proliferative ovarian lesions in various aged rat strains. One particularly provocative lesion was a malignant neoplastic proliferation in the renal pelvic region of a cynomolgus macaque from a 21-day study. Additional challenging lesions included thyroid proliferative lesions in Zebrafish and gross findings in fish larvae during routine chemical screening. The Rabbit and Minipig International Harmonization of Nomenclature and Diagnostic Criteria Organ Working Groups also presented a series of challenging lesions.

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Mixed Germ Cell Tumor with Embryonal Carcinoma, Choriocarcinoma, and Epithelioid Trophoblastic Tumor in the Ovary of a Cynomolgus Monkey

Cited by 9 publications

References 17 publications

Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat

Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat

Ovarian Intermediate Trophoblastic Tumors

Proceedings of the 2018 National Toxicology Program Satellite Symposium

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