An 11-year-old female goat had invasive and metastatic endometrial adenocarcinoma in the
uterus. There was a notable proliferation of endometrial epithelial cells in a tubular
growth pattern, with a desmoplastic response. The endometrial epithelial tumor cells
metastasized to the kidney, liver and lung. In contrast to the primary and metastatic
tumor cells, pleomorphic tumor cells with a choriocarcinoma-like growth pattern
infiltrated the mesometrium. Cell proliferation activity was high in both types of tumor
cells. Both types of tumor cells expressed cytokeratins AE1/AE3, 7 and CAM5.2;
choriocarcinomatous cells also had positive immunoreactions to human chorionic
gonadotropin, human placental alkaline phosphatase and α-inhibin. The present case was
diagnosed as endometrial adenocarcinoma with choriocarcinomatous differentiation.
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