Mixed etiology COVID-19 associated acute rhinosinusitis caused by two Aspergillus species

Tabarsi, Payam; Sharifynia, Somayeh; Toutkaboni, Mihan Pourabdollah; Abtahian, Zahra; Rahdar, Mohammad; Mirahmadian, Arefeh; Hakamifard, Atousa

doi:10.1016/j.amsu.2022.103365

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Rhinosinusitis, which is caused by two or three fungal co-infections, (Aspergillus and Candida, or Aspergillus and Mucor, or Candida and Mucor etc.) in patients during COVID-19 infection or especially in post-COVID-19 period have been reported in a limited number of studies [20,21]. Moreover, the description of rhinosinusitis in patients in post-COVID-19 period is still scarce in recent literature [22].…”

Section: Discussionmentioning

confidence: 99%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

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The aim is to identify the etiology, clinical and morphological features of rhinosinusitis in patients in post-COVID-19 period. Materials and methods: In the present study, it was carried out the analysis of 11 cases of rhinosinusitis, which developed after COVID-19 infection. The diagnosis of rhi¬nosinusitis was established on the basis of anamnesis, clinical and laboratory examination, specialized instrumental examination (rhinoendoscopy, X-ray, magnetic resonance imaging, spiral and 3D computed tomography). All patients underwent endoscopic sanitation of the nasal cavity, expansion of the maxillary anastomosis, maxillary sinusotomy, sanitation of the maxillary sinuses and removal of pathologically altered tissues. Microbiological examination of the swab from the nasal cavity was carried out in all patients. Histological and morphometric research methods were used during the morphological study of surgical material. The nonparametric Mann-Whitney U test was used to compare the means in the groups. Results: The conducted comprehensive study made it possible to identify chronic atrophic rhinosinusitis at the stage of exacerbation caused by associations of bacteria and fungi in patients in post-COVID-19 period. Among bacteria, the authors most often noted Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumonia, Streptococcus pneumonia and Enterococcus faecalis. Among fungi, there were Aspergillus, Candida, Mucor and Coccidioides. Fungal infection was characterized by invasion into the mucous membrane of the nose and paranasal sinuses. In patients in post-COVID-19 period the invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation was predominantly bilateral, characterized by the involvement of several or all paranasal sinuses in the process. Patients with such pathology complained of periodic fever, headaches and malaise; nasal congestion and constant difficulty in nasal breathing; yellowish-greenish-reddish discharge from the nasal cavity, sometimes with a fetid odor; discomfort and pain in the area of paranasal sinuses; immobility of the eyeball, hyposmia or anosmia; reduction or complete loss of vision. Frequent risk factors for the development of invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation in patients in post-COVID-19 period were the information about moderate or severe course of this infection in anamnesis; comorbidities (predominantly diabetes mellitus, hypertensive disease and ischemic heart disease). Conclusions: The study conducted by the authors made it possible to identify the etiological, clinical and morphological features, as well as risk factors of rhinosinusitis in patients in post-COVID-19 period. This information will contribute to a better understanding of such pathology by the doctors and improve the diagnostic and treatment process.

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Section: Discussionmentioning

confidence: 99%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

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“…The physiological roles of the paranasal sinuses, including the humidification and heating of inhaled air, may intersect with observed clinical presentations in COVID-19 patients, offering insights into the pathophysiological impact of the virus on these structures. The association of COVID-19 with acute rhinosinusitis, attributed to fungal species like Aspergillus , further complicates the relationship between COVID-19 and sinus health, suggesting that mucosal thickening could also reflect a broader spectrum of sinusitis conditions [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Anosmia in COVID-19: Investigating the Role of Paranasal Sinus Mucosal Thickening

Sampath,

Thiyagarajan,

Tamilarasan

et al. 2024

Cureus

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Background Anosmia has been identified as a distinctive symptom of COVID-19, leading to hypotheses about its pathophysiological underpinnings, including the potential role of paranasal sinus mucosal thickening. Objective To investigate the association between paranasal sinus mucosal thickening and anosmia in COVID-19 patients, providing insights into the complex clinical manifestations of the disease. Methods This retrospective cohort study analyzed CT paranasal sinus from 270 confirmed COVID-19 patients, divided into those with anosmia (n = 23, 8.52%) and those without anosmia (n = 247, 91.48%). Statistical analysis, including independent t-tests, was employed to compare mucosal thickening between the groups. Results The study found an average mucosal thickening of 0.03 in patients with anosmia and 0.02 in those without, with no statistically significant difference between the groups (p = 0.480, which is greater than 0.05). The findings suggest that mucosal thickening in the paranasal sinuses does not serve as a definitive correlate of anosmia among COVID-19 patients. Conclusion The absence of a significant correlation between paranasal sinus mucosal thickening and anosmia in COVID-19 patients indicates that the pathophysiology of anosmia may involve factors beyond anatomical changes, including direct viral effects and systemic inflammatory responses.

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“…Sinusitis characterized by nonspecific inflammation of the mucous membrane of the sinuses, is often caused by viral or bacterial infection or allergy, and it can be classified into acute and chronic types. Liposomes loaded with amphotericin B have been used in the clinical treatment of acute invasive fungal rhinosinusitis (AIFRS) (Alabdullah & Yousfan, 2023;Fadda et al, 2021;Kawaji-Kanayama et al, 2020;Tabarsi et al, 2022a;Tabarsi et al, 2022b). For chronic sinusitis, often associated with persistent infection of Staphylococcus aureus, attracting numerous attention to combate this bacterium.…”

Section: Application Of Liposomes In Other Organ Repairmentioning

confidence: 99%

The application strategy of liposomes in organ targeting therapy

Xun,

Li,

Xue

2024

WIREs Nanomed Nanobiotechnol

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Liposomes—microscopic phospholipid bubbles with bilayered membrane structure—have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ‐specific diseases. For further successful development of this field, this review summarized liposomal strategies for targeting different organs in series of major human diseases, including widely studied cardiovascular diseases, liver and spleen immune diseases, chronic or acute kidney injury, neurodegenerative diseases, and organ‐specific tumors. It highlights recent advances of liposome‐mediated therapeutic agent delivery for disease intervention and organ rehabilitation, offering practical guidelines for designing organ‐targeted liposomes.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures

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Mixed etiology COVID-19 associated acute rhinosinusitis caused by two Aspergillus species

Cited by 7 publications

References 14 publications

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Anosmia in COVID-19: Investigating the Role of Paranasal Sinus Mucosal Thickening

The application strategy of liposomes in organ targeting therapy

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