Mixed endocrine-glandular carcinoma of cecum

Liang, Tung-Jung; Ke, Tuan-Ying

doi:10.1016/j.fjs.2014.05.003

“…A primarily platinum-oriented adjuvant treatment is used in the treatment of MANEC due to its effectiveness in the treatment of small cell lung carcinoma, a neoplasm that shows histological similarities to that of the small cell neuroendocrine component type [ 8 ]. Previous studies have shown a combination of cisplatin and etoposide to be associated with a 67% response rate and a median survival of 19 months in patients with metastatic anaplastic neuroendocrine carcinomas of the colon and rectum and a median progression-free survival of 8.9 months in patients with colorectal neuroendocrine carcinomas [ 5 , 8 ]. The use of a FOLFOX (FOL – folinic acid F – fluorouracil OX – oxaliplatin) regimen, a vincristine-based regimen with adriamycin, and a regimen based on carboplatin have also been reported to show improved survival [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Mixed Adenoneuroendocrine Carcinoma of the Ileocecal Valve

González¹,

Skrove²,

Sharma³

et al. 2019

Cureus

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Mixed adenoneuroendocrine carcinoma (MANEC) is an uncommon neoplasm with uncertain pathophysiology. In order to be classified as MANEC, the tumor must contain at least 30% neuroendocrine cells and 30% adenocarcinoma. The standardization of MANEC treatment has historically been difficult due to the lack of diagnostic histological classification. In 2010, the World Health Organization (WHO) finally recognized this uncommon condition as a specific colon cancer entity in the hopes of better specifying treatment options in the future.We present a case of high-grade MANEC of the cecum with metastasis in 3/10 lymph nodes to further characterize the diagnostic modalities and treatment options of the disease. MANECs only account for 3%-9.6% of all colorectal cancers and only eight cases have been reported in the cecum to date, making the following case report exceptionally rare.

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“…MANECs are histologically defined as carcinomas composed of both gland-forming epithelial and neuroendocrine neoplasms and must contain at least 30% of both to be classified as such. These types of mixed tumors are extremely rare, and they are notoriously aggressive with a high metastatic potential, which appears to arise from the neuroendocrine component of the tumor [5].…”

Section: Discussionmentioning

confidence: 99%

“…High-grade neoplasms have been documented in the esophagus, stomach, large bowel, and in the anorectal segment. The prognosis of high-grade lesions depends on the stage and tumor type with a worse survival associated with distant metastases [5].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown a combination of cisplatin and etoposide to be associated with a 67% response rate and a median survival of 19 months in patients with metastatic anaplastic neuroendocrine carcinomas of the colon and rectum and a median progression-free survival of 8.9 months in patients with colorectal neuroendocrine carcinomas [5,8]. The use of a FOLFOX (FOL -folinic acid F -fluorouracil OX -oxaliplatin) regimen, a vincristine-based regimen with adriamycin, and a regimen based on carboplatin have also been reported to show improved survival [8].…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Mixed Adeno-Neuroendocrine Carcinoma of the Ileocecal Valve

Skrove

¹

,

Gonzalez

²

,

Saline

³

et al. 2016

American Journal of Gastroenterology

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Mixed adenoneuroendocrine carcinoma (MANEC) is an uncommon neoplasm with uncertain pathophysiology. In order to be classified as MANEC, the tumor must contain at least 30% neuroendocrine cells and 30% adenocarcinoma. The standardization of MANEC treatment has historically been difficult due to the lack of diagnostic histological classification. In 2010, the World Health Organization (WHO) finally recognized this uncommon condition as a specific colon cancer entity in the hopes of better specifying treatment options in the future.We present a case of high-grade MANEC of the cecum with metastasis in 3/10 lymph nodes to further characterize the diagnostic modalities and treatment options of the disease. MANECs only account for 3%-9.6% of all colorectal cancers and only eight cases have been reported in the cecum to date, making the following case report exceptionally rare.

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Mixed adenoneuroendocrine carcinoma of the colon and rectum

Qiu

¹

,

Pellino

²

,

Warren

³

et al. 2018

Acta Chirurgica Belgica

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Mixed adenoneuroendocrine carcinoma (MANEC) are rare cancers of the gastrointestinal (GI) and pancreatobiliary tract. They are characterized by the presence of a combination of epithelial and neuroendocrine elements, where each component represents at least 30% of the tumour. Review of literature and consolidation of clinicopathological data. Sixty-one cases of colorectal MANEC have been reported in literature and one seen in this centre. The median age of the patients affected was 61.9 ± 12.4 years (20-94 years). Male to female ratio is 1.0:1.2. Presentations were similar to other colorectal malignancies. 58.0% of colorectal MANECs were found in the right colon, 8.1% cases in the transverse, 16.1% in the left colon, 16.1% in the rectum. These tumours appeared invasiveness 79.1% were T3-T4. Over 90% of cases were presented with metastatic disease. The majority of patient underwent surgical resection of the primary cancer (96.6%). Of these, 10 operations (17.9%) were emergency operations due to obstruction, perforation, or bleeding. Three patients received first line palliative care. In eight cases (13.8%), patients underwent adjuvant chemotherapy. The median overall survival after diagnosis was 10 ± 2.4 months (95% CI: 5.37-14.64 months). MANECs are rare but aggressive colorectal cancers. Surgical resection of localized disease with adjuvant chemotherapy appears to significantly improve survival in small case series. Further understanding through the sharing of experiences is required.

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Mixed endocrine-glandular carcinoma of cecum

Cited by 3 publications

References 7 publications

A Rare Case of Mixed Adenoneuroendocrine Carcinoma of the Ileocecal Valve

A Rare Case of Mixed Adenoneuroendocrine Carcinoma of the Ileocecal Valve

A Rare Case of Mixed Adeno-Neuroendocrine Carcinoma of the Ileocecal Valve

Mixed adenoneuroendocrine carcinoma of the colon and rectum

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