Mixed adenoneuroendocrine carcinoma of the colon and rectum

Abstract

Mixed adenoneuroendocrine carcinoma (MANEC) are rare cancers of the gastrointestinal (GI) and pancreatobiliary tract. They are characterized by the presence of a combination of epithelial and neuroendocrine elements, where each component represents at least 30% of the tumour. Review of literature and consolidation of clinicopathological data. Sixty-one cases of colorectal MANEC have been reported in literature and one seen in this centre. The median age of the patients affected was 61.9 ± 12.4 years (20-94 years). Male to female ratio is 1.0:1.2. Presentations were similar to other colorectal malignancies. 58.0% of colorectal MANECs were found in the right colon, 8.1% cases in the transverse, 16.1% in the left colon, 16.1% in the rectum. These tumours appeared invasiveness 79.1% were T3-T4. Over 90% of cases were presented with metastatic disease. The majority of patient underwent surgical resection of the primary cancer (96.6%). Of these, 10 operations (17.9%) were emergency operations due to obstruction, perforation, or bleeding. Three patients received first line palliative care. In eight cases (13.8%), patients underwent adjuvant chemotherapy. The median overall survival after diagnosis was 10 ± 2.4 months (95% CI: 5.37-14.64 months). MANECs are rare but aggressive colorectal cancers. Surgical resection of localized disease with adjuvant chemotherapy appears to significantly improve survival in small case series. Further understanding through the sharing of experiences is required.

Colorectal neuroendocrine carcinoma: A case report and review of the literature

“…Neuroendocrine carcinoma (NEC) of colon and rectum is a rare neuroendocrine tumor (NET) type that accounts for < 1% of all colorectal malignancies[1]. The clinical progression of NECs includes highly aggressive growth and rapid dissemination along with a high tendency for metastasis[2]. Moreover, these tumors could be detected at advanced stage[3].…”

Perforated High-Grade Mixed Neuroendocrine Nonneuroendocrine Neoplasm of Cecum: Unusual Presentation of Rare Disease

“…The composite type where neuroendocrine and nonendocrine cells are intermingled, the collision type where the neuroendocrine and nonendocrine components are distinct but abutting each other, and the amphicrine type where both components are present within the same cell. In 2010 WHO classification, the terminology "Collision" and "Composite" tumors were updated into MANECs [6].…”

A Rare Collision Tumor: Adenocarcinoma in the Ampulla of Vater and Neuroendocrine Tumor in the Lower Part of the Common Bile Duct

“…The tumors are predominantly found on endoscopic retrograde cholangiopancreatography in patients with obstructive jaundice or acute biliary pancreatitis. The concurrence of NET with adenocarcinoma (so-called adenocarcinoid tumor) is an unusual phenomenon in the gastrointestinal tract, and has been reported in the esophagus, stomach, small intestine, vermiform appendix, colon and rectum [ 14 - 16 ]. In the duodenum, only three cases of adenocarcinoma synchronous with neuroendocrine neoplasm have been reported [ 3 - 5 ].…”