Mixed depressant and stimulant actions of morphine and their relationship to brain acetylcholine

Domino, Edward F.; Vasco, Michael R.; Wilson, Ann

doi:10.1016/0024-3205(76)90213-7

Cited by 69 publications

(13 citation statements)

References 41 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morphine and other mu opioids, when administered acutely to rats, produce a biphasic effect on locomotion, with an initial decrease in locomotion during the first hour of testing, followed by a delayed increase over the next 2-3 h (Babbini and Davis 1972;Babbini et al 1975;Domino et al 1976;Vasko and Domino 1978;Brady and Holtzman 1981;Bartoletti et al 1987;Trujillo and Swadley-Lewellen 1997;SwadleyLewellen et al 1998). With chronic administration there is a decrease in the locomotor depression (tolerance) and an increase in the locomotor stimulation (sensitization) (Babbini and Davis 1972;Babbini et al 1975;Domino et al 1976;Vasko and Domino 1978;Brady and Holtzman 1981;Bartoletti et al 1987;Trujillo and Swadley-Lewellen 1997;. Thus, although the dependent measure in each case is locomotion, different phases of morphine's effects must be examined in order to study tolerance and sensitizationtolerance to locomotor depression must be studied during the early phase of morphine's effects, and sensitization to locomotor stimulation must be studied during the later phase.…”

Section: Discussionmentioning

confidence: 93%

Are NMDA receptors involved in opiate-induced neural and behavioral plasticity?

2000

View full text Add to dashboard Cite

NMDA receptor antagonists appear to inhibit the neural plasticity underlying some forms of opiate tolerance, sensitization and physical dependence, suggesting that NMDA receptors are involved in the development of these drug-induced changes in behavior. Further research will help to determine the neural mechanisms responsible for these phenomena, and the therapeutic potential for drugs acting on the NMDA receptor complex in the treatment of pain and addiction.

show abstract

Section: Discussionmentioning

confidence: 93%

Are NMDA receptors involved in opiate-induced neural and behavioral plasticity?

2000

View full text Add to dashboard Cite

show abstract

“…Low doses of morphine (1-2 mg/kg) produce hyperactivity (Fog 1970;Babbini and Davis 1972;Ayhan and Randrup 1973;Iwamoto 1981), whilst higher doses produce hypomobility, and at 20 mg/kg catalepsy is observed (Fog 1970;Babbini and Davis 1972;Domino et al 1976;Vasko and Domino 1978;Brady and Holtzman 1981). In addition, central application of DAGO to adult rats has been shown to either stimulate or inhibit locomotor activity depending on the doses employed (Locke and Holtzman 1986).…”

Section: Discussionmentioning

confidence: 96%

Behavioural effects of selective ?-, ?-, and ?-opioid agonists in neonatal rats

Jackson

Kitchen

1989

Psychopharmacology

View full text Add to dashboard Cite

The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt sedation in all the age groups and also induced catalepsy which was particularly apparent in the 5- and 10-day-old animals. These compounds did not produce any signs of behavioural activation in the neonatal rats. In contrast, rat pups treated with the kappa-agonists U50,488H and PD 117,302 (1,10 mg/kg IP) exhibited marked hyperactivity with increases in wall-climbing and locomotion. Sedative effects of the highest dose of the kappa-agonists began to emerge, however, as the animals grew older, resulting in significant decreases in behaviours such as gnawing and grooming at 20 days of age. The kappa-agonist (+)-tifluadom (0.1-10 mg/kg), but not its corresponding (-)-isomer, produced an increase in activity in 5-day-old rats, thus extending the observations made with U50,488H and PD 117,302 and establishing the stereoselective nature of the response. The involvement of kappa-receptors in opioid-induced hyperactivity was further substantiated by using a variety of opioid antagonists. In this context, the increase in activity induced by U50,488H (10 mg/kg) in 5-day-old neonates was attenuated by naltrexone (1 mg/kg IP) but not by larger doses (10 mg/kg) of either M8008 (which has low affinity for kappa-receptors) or the selective delta-receptor antagonist ICI 174,864.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…In particular, the ability of morphine to modify locomotor activity, pain perception, and to induce reinforcing behavior is well documented (Kuschinsky and Hornykiewicz, 1974;Ling and Pasternak, 1983;Devine and Wise, 1994). Several studies in rats have shown that morphine causes dose-and time-related opposite effects on locomotor activity: typically, low doses increase it, while larger doses induce sedation and catalepsy (Babbini and Davis, 1972;Buxbaum et al, 1973;Domino et al, 1976). In contrast, morphine administration in mice produces a dose-dependent stimulation known as ''running fit'' syndrome.…”

Section: Introductionmentioning

confidence: 99%

Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice

Fadda

Scherma

Fresu

et al. 2005

Synapse

View full text Add to dashboard Cite

Numerous studies have demonstrated that genetic factors significantly influence opioid ability to induce behavioral modification in mice. This differential sensitivity has been extensively studied, particularly in the DBA/2J and C57BL/6J strains. In the present study, using the "in vivo" microdialysis technique in these strains, we investigated the effect of morphine administration on the extracellular levels of dopamine (DA), serotonin (5-HT), and their metabolites in the nucleus accumbens and dorsal striatum--areas thought to be involved in morphine-induced locomotor hyperactivity. In the nucleus accumbens, morphine (20 mg/kg) significantly increased extracellular levels of DA in both strains. However, in dorsal striatum the morphine-induced increase of extracellular DA was lower in DBA/2J mice than in C57BL/6J. Moreover, morphine significantly stimulated 5-HT and 5-hydroxyindolacetic acid (5-HIAA) release both in nucleus accumbens and dorsal striatum of C57BL/6J mice, whereas it decreased 5-HT release without modifying 5-HIAA levels in DBA/2J mice. These results suggest that the different behavioral and biochemical responses to acute morphine described in these two strains could be mediated by different sensitivity of both the dopaminergic and the serotonergic systems.

show abstract

Mixed depressant and stimulant actions of morphine and their relationship to brain acetylcholine

Cited by 69 publications

References 41 publications

Are NMDA receptors involved in opiate-induced neural and behavioral plasticity?

Are NMDA receptors involved in opiate-induced neural and behavioral plasticity?

Behavioural effects of selective ?-, ?-, and ?-opioid agonists in neonatal rats

Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice

Contact Info

Product

Resources

About