Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice

Fadda, Paola; Scherma, María; Fresu, A; Collu, Maria; Fratta, Walter

doi:10.1002/syn.20122

Cited by 65 publications

(41 citation statements)

References 48 publications

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“…Microdialysis and voltammetry measurements have shown that the extracellular DA concentration is lower in the NAc than in the dorsal striatum (Jones et al, 1995;Keck et al, 2002;Cragg, 2003;Melendez et al, 2003;Fadda et al, 2005). We found that lower basal DA release (i.e., DA release evoked by 1p) correlated with stronger facilitation of DA release in the NAc shell during phasic stimulation.…”

Section: Tonic and Phasic Dopamine Transmission In The Striatummentioning

confidence: 51%

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

et al. 2009

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Dopamine (DA) release varies within subregions and local environments of the striatum, suggesting that controls intrinsic and extrinsic to the DA fibers and terminals regulate release. While applying fast-scan cyclic voltammetry and using tonic and phasic stimulus trains, we investigated the regulation of DA release in the dorsolateral to ventral striatum. The ratio of phasic-to-tonic-evoked DA signals varied with the average ongoing firing frequency, and the ratio was generally higher in the nucleus accumbens (NAc) compared with the dorsolateral striatum. At the normal average firing frequency, burst stimulation produces a larger increase in the DA response in the NAc than the dorsolateral striatum. This finding was comparable whether the DA measurements were made using in vitro brain slices or were recorded in vivo from freely moving rodents. Blockade of the dopamine transporters and dopamine D 2 receptors particularly enhanced the tonic DA signals. Conversely, blockade of nicotinic acetylcholine receptors (nAChRs) containing the ␤ 2 subunit (␤ 2 *) predominantly suppressed tonic DA signals. The suppression of tonic DA release increased the contrast between phasic and tonic DA signals, and that made the frequencydependent DA dynamics between the dorsolateral striatum and NAc more similar. The results indicate that intrinsic differences in the DA fibers that innervate specific regions of the striatum combine with (at least) DA transporters, DA receptors, and nAChRs to regulate the frequency dependence of DA release. A combination of mechanisms provides specific local control of DA release that underlies pathway-specific information associated with motor and reward-related functions. Dopamine (DA) neurons operate in distinct tonic and phasic timescales to differentiate behaviorally relevant information (Schultz, 2007). DA neurons discharge tonically at low frequencies that consist of individual action potentials without bursts . Periodically, DA neurons fire in phasic bursts of near 20 Hz and greater (Hyland et al., 2002;Robinson et al., 2004). Evidence indicates that phasic or burst firing induces greater extracellular DA release compared with tonic, single-spike firing activity (Gonon, 1988;Grace, 1991;Floresco et al., 2003). Those tonic and phasic signals arise from midbrain DA neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) that innervate the whole dorsal to ventral extent of the striatum. Although the DA neurons that project to the prefrontal cortex may have higher discharge rates (Chiodo et al., 1984;Lammel et al., 2008), many midbrain DA neurons often exhibit similar overall firing properties (Schultz, 1986;Clark and Chiodo, 1988;Gariano et al., 1989;Robinson et al., 2004). Reward-related sensory input, however, such as that initiated by an addictive drug, enhances DA release to varying degrees depending on the dopaminergic pathway and target region (Pontieri et al., 1996;Nisell et al., 1997;Shi et al., 2000;Di Chiara et al., 2004;Janhunen and Ahtee, 2007). Th...

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Section: Tonic and Phasic Dopamine Transmission In The Striatummentioning

confidence: 51%

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

et al. 2009

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“…In addition, administration of a dopamine D2 receptor antagonist, or combined D1-D2 receptor antagonism, attenuates the locomotor stimulant response to ethanol in FAST mice (Shen et al, 1995a). Similarly, morphine elicits increases in extracellular dopamine levels in the NAc (Fadda et al, 2005;Murphy et al, 2001) and dopamine depletion or D1 receptor antagonism diminishes the acute locomotor stimulant response to morphine in mice (Hnasko et al, 2005;Jeziorski & White, 1995). Therefore, ethanol-and morphineinduced locomotor stimulation in FAST mice may be occurring through a similar activation of mesolimbic dopamine systems.…”

Section: Discussionmentioning

confidence: 99%

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

Holstein

Phillips²

2006

Pharmacology Biochemistry and Behavior

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Mice selectively bred for divergent sensitivity to the locomotor stimulant effects of ethanol (FAST and SLOW) also differ in their locomotor response to morphine. The GABA B receptor has been implicated in the mediation of locomotor stimulation to both ethanol and morphine, and a reduction in ethanol-induced stimulation has been found with the GABA B receptor agonist baclofen in FAST mice. We hypothesized that GABA B receptor activation would also attenuate the locomotor stimulant responses to morphine in these mice. In order to test this hypothesis, baclofen was administered to FAST-1 and FAST-2 mice 15 min prior to morphine, and activity was recorded for 30 min. Baclofen attenuated stimulation to 32 mg/kg morphine in FAST-1 mice, but only at a dose that also reduced saline activity. There was no stimulant response to 32 mg/kg morphine in FAST-2 mice, or to 16 mg/kg or 48 mg/kg morphine in FAST-1 mice, but the combination of baclofen with these morphine doses accentuated locomotor activity. Therefore, it appears that GABA B receptor activation is not a common mechanism for the locomotor stimulant responses to ethanol and morphine in FAST mice; however, these data suggest that GABA B receptor activation may instead enhance some of the behavioral effects of morphine.

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“…Indeed, it was shown that fentanyl can engender some discriminative stimulus properties of cocaine (Colpaert et al, 1979) and amphetamine produces an increasing amount of fentanyl-appropriate responding when the training doses is progressively lowered (Colpaert et al, 1980) in animals trained to discriminate the interoceptive cues of a drug. There is also an overlap in the net effect of psychomotor stimulants and opioids on dopamine release in the striatum (Fadda et al, 2005;Murphy et al, 2001;Zocchi et al, 2003). However, this overlap occurs only at doses of morphine and cocaine that would not be expected to induce detectable levels of dopamine release as measured by in vivo microdialysis in the C57BL/6 mouse (Rouge-Pont et al, 2002), although in CD1 mice the dopamine levels are comparable following low doses (Zocchi et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

A Data Mining Approach to In Vivo Classification of Psychopharmacological Drugs

Kafkafi

Yekutieli

Elmer

2008

Neuropsychopharmacol

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Data mining is a powerful bioinformatics strategy that has been successfully applied in vitro to screen for gene-expression profiles predicting toxicological or carcinogenic response ('class predictors'). In this report we used a data mining algorithm named Pattern Array (PA) in vivo to analyze mouse open-field behavior and characterize the psychopharmacological effects of three drug classesFpsychomotor stimulant, opioid, and psychotomimetic. PA represents rodent movement with B100 000 complex patterns, defined as multiple combinations of several ethologically relevant variables, and mines them for those that maximize any effect of interest, such as the difference between drug classes. We show that PA can discover behavioral predictors of all three drug classes, thus developing a reliable drug-classification scheme in small group sizes. The discovered predictors showed orderly dose dependency despite being explicitly mined only for class differences, with the high doses scoring 4-10 standard deviations from the vehicle group. Furthermore, these predictors correctly classified in a dose-dependent manner four 'unknown' drugs (ie that were not used in the training process), and scored a mixture of a psychomotor stimulant and an opioid as being intermediate between these two classes. The isolated behaviors were highly heritable (h 2 450%) and replicable as determined in 10 inbred strains across three laboratories. PA can in principle be applied for mining behaviors predicting additional properties, such as within-class differences between drugs and within-drug dose-response, all of which can be measured automatically in a single session per animal in an open-field arena, suggesting a high potential as a tool in psychotherapeutic drug discovery.

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Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice

Cited by 65 publications

References 48 publications

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

A Data Mining Approach to In Vivo Classification of Psychopharmacological Drugs

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