Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties

Encinas, N.; Angulo, Mercedes; Astorga, Carlos; Colilla, Montserrat; Izquierdo‐Barba, Isabel; Vallet‐Regí, María

doi:10.1016/j.actbio.2018.12.012

Cited by 67 publications

(51 citation statements)

References 55 publications

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“…[5,6] Among these, low colloidal stability (particle aggregation) can be fatal to the function of particles, such as drug release and targeting, which are closely related to the immune recognition system (fast cellular uptake because of increased size by aggregation and nonspecific absorption). [7,8] Particle aggregation is caused spontaneously not only because of low repulsive force compared to Van Der Waals attraction acting between particles but also by nonspecific synthetic method for SiZwit is divided into two steps. First, we functionalized silica nanoparticles with an amino group using (3-aminopropyl)triethoxysilane (APTES, SiNH 2 ), which is a well-known amine functionalizing agent.…”

Section: Introductionmentioning

confidence: 99%

“…of the poly(ethylene glycol) (PEG) polymer chain length, and rapid oxidation by metal ions in the bioenvironment, have been reported. [13,19] "Zwitterionization" is a technology that involves grafting a zwitterion on the surface of a nanoparticle; various studies have been conducted on field of drug delivery systems [8] and antibacterial surfaces. [20,21] A zwitterion contains both positive (PCG) and negatively charged groups (NCG), thus forming a water bonded hydration layer stronger than PEG due to electrostatic interactions and hydrogen bonding with H 2 O molecules at an internally balanced pH value (net-charge close to zero).…”

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confidence: 99%

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Efficient Drug Delivery Carrier Surface without Unwanted Adsorption Using Sulfobetaine Zwitterion

Jung

Park

Choi

et al. 2020

Adv Materials Inter

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adsorption of proteins on the particle and electrostatically adsorbed salt ions in a physiological environment. [9] Currently, there are several methods available for increasing colloidal stability, for example, PEGylation, [10,11] polymer coating, [12] and zwitterionization. [13-15] Polymer coating imparts excellent colloidal stability to particles using electrostatic repulsion; however, because of surface charge blocking by salt ions in a physiological environment, fast aggregation can occur, and it is impractical for applications in many fields. [16] In recent studies, PEGylation was performed on a particle providing biocompatibility and stability to the particle in physiological solution. [17] PEGylated particles can form a hydration layer through hydrogen bonding with H 2 O molecules, imparting colloidal stability by hydration repulsion. [18] However, shortcomings, such as largely increased hydrodynamic diameter, decreased activity of nanoparticles because

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Efficient Drug Delivery Carrier Surface without Unwanted Adsorption Using Sulfobetaine Zwitterion

Jung

Park

Choi

et al. 2020

Adv Materials Inter

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“…A similar approach using amino and phosphonate groups was recently reported, yielding MSNs with extremely low protein adsorption and excellent antibacterial properties. In addition, the nanoparticles showed great biocompatibility with preosteoblasts, assuring their biocompatibility for the treatment of bone infection [176]. Interestingly, this zwitterionic approach using two small molecules can be employed to design pH-responsive gatekeepers by taking advantage of the interaction between both short chains, which interact at physiological pH and experience repulsion forces at acid pH [177].…”

Section: Preventing Protein and Bacterial Adhesion And Biofilm Formatmentioning

confidence: 99%

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

2020

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Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major issue for modern societies as a consequence of their progressive ageing. Even though these pathologies can be currently treated in the clinic, some of those treatments present drawbacks that may lead to severe complications. For instance, chemotherapy lacks great tumor tissue selectivity, affecting healthy and diseased tissues. In addition, the inappropriate use of antimicrobials is leading to the appearance of drug-resistant bacteria and persistent biofilms, rendering current antibiotics useless. Furthermore, current antiosteoporotic treatments present many side effects as a consequence of their poor bioavailability and the need to use higher doses. In view of the existing evidence, the encapsulation and selective delivery to the diseased tissues of the different therapeutic compounds seem highly convenient. In this sense, silica-based mesoporous nanoparticles offer great loading capacity within their pores, the possibility of modifying the surface to target the particles to the malignant areas and great biocompatibility. This manuscript is intended to be a comprehensive review of the available literature on complex bone diseases treated with silica-based mesoporous nanoparticles—the further development of which and eventual translation into the clinic could bring significant benefits for our future society.

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“…Wiesner group (162,163) described the fabrication of "Cornell dots or C dots" (labeled 124 IcRGDY-PEG-C dots) as the first nanosilica approved by the FDA for clinical assays. A smart core-shell nanosilica containing Cy5 dye and 124 I radiolabels for optical-PET (positron emission tomography) dual imaging was fabricated and modified with PEG and cRGDY peptides as target agent for molecular expression in human melanoma xenografts (162,163).…”

Section: Clinical Translation Challenges and Future Outlookmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties

Abstract: Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties,

Cited by 67 publications

References 55 publications

Efficient Drug Delivery Carrier Surface without Unwanted Adsorption Using Sulfobetaine Zwitterion

Efficient Drug Delivery Carrier Surface without Unwanted Adsorption Using Sulfobetaine Zwitterion

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

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