Mixed Capillary Hemangioblastoma and Glioma

Abstract

The histopathologic features of four cases of mixed capillary hemangioblastoma and glioma are described. In three cases, two of which arose in the cerebellum and one in the spinal cord, the hemangioblastic component may have originated from a neoplastic proliferation of the exuberant vascular stroma in a glial tumor. In a fourth case, a cerebellar hemangioblastoma was surrounded by a peripheral rim of atypical neoplastic-looking astrocytes ("reactive glioma"). The controversial concept of the "angioglioma" is reviewed, and it is proposed that the term be used to designate only true mixed tumors of glial and vascular tissue origin whose histologic features conform to the examples described in this report.

Combined angioma and glioma (angioglioma)

“…A review of the literature disclosed 41 case reports of solitary intracranial angioglioma including the current study [ 1,[3][4][5]10,12,, eight cases of two separated tumors either in the same or opposite hemispheres [26-331, and two examples of gliomas that occurred subsequently at the site of the angioma 119,341. We have not included the two latter conditions in our study, since we are concerned with combined or intermixed tumors within one lesion.…”

“…Angiomas comprise about 2% of intracranial lesions but have been reported as high as 7.8% in a series described by Courville [2] in the United States. Angiomas may be found in combination with other tumors in the neuraxis and various neoplastic mixtures have been described in recent years (viz) angiomas with astrocytoma [1,[3][4][5], colloid cysts [ 61, meningioma [7], and neurilemmoma [ 8 ] . The angiomatous proliferation in certain gliomas is often passed off as vascular proliferation and is rarely considered to constitute a distinct and separate neoplastic change [S].…”

Original article The coexistence of pleomorphic xanthoastrocytoma and arteriovenous malformation. A

“…The lesions, consisting of mixed tumours of glial and vascular origin, particularly of cavernous or arteriovenous type, have been often defined as angiogliomas [3,13,19,25,30,41]. The term "angioglioma" is confusing and according to some authors should not be used to determine the true coincidence of vascular and neoplastic glial lesions.…”

Association between cavernous angioma and cerebral glioma. Report of two cases and literature review of so-called angiogliomas

“…Some authors 1,5,6,11,20,21 expressed different etiological hypothesis including: genetical predisposition 20 ; reactive or malformative nature 1,6,21 ; viral origin 5 ; and exceptional …”