Research on personality vulnerability to depression is characterized by a "main effect" approach, often at the expense of examining interactions among various dimensions of vulnerability. To compare the "main effect" and "interactive-synergetic" approaches, we utilized data from a longitudinal study of adolescent adjustment. Focusing on dependency, self-criticism, and efficacy, the three factors of the adolescent version of the Depressive Experiences Questionnaire (DEQ; Blatt, Schaffer, Bers, & Quinlan, 1992), we found support for the interactive-synergetic approach. Dependency and self-criticism interacted in predicting changes in depressive and internalizing symptoms (under low efficacy), and among boys-changes in internalizing and externalizing symptoms. Results illuminate the synergetic interplay among dimensions of risk and resilience in clinical research and practice.