Mixed Adenoneuroendocrine Carcinoma in the Transverse Colon: An Infrequent Neoplasm in an Unusual Location

Cendra, Cristina Sánchez; Barrio, Belén Pascual; Vila, Beatriz Losada; Gonzalez, Maria del Carmen Pantín; Maestu, Javier de la Rubia; Martel, Ignacio Juez; Rocabado, Rocío S Cardozo

doi:10.35248/2684-1258.17.3.131

Cited by 1 publication

(2 citation statements)

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“…In contrast, in the Asian literature, gastrointestinal-NEN mostly occurred in the rectum[ 68 ]. In the colon, mixed tumor seems to be commonly occur in the rectosigmoid/sigmoid colon, and is rare in the ascending/transverse colon, cecum and ileocecal valve[ 77 , 80 , 81 , 83 - 85 , 88 , 92 , 95 , 97 , 99 , 103 - 105 ]. In a review of sixty one cases of colorectal MANEC by Qiu et al [ 100 ] 58% were located in the right colon, 8.1% in the transverse, 16.1% in the left colon and 16.1% in the rectum.…”

Section: Discussionmentioning

confidence: 99%

“…Lymph node metastases were detected in 72% of the patients, 20% presented with distant metastasizes while all cases presented with lymphovascular invasion[ 14 , 77 ]. Most commonly reported distant metastatic sites were liver, paraaortic lymph node, bone and lung followed by peritoneum[ 14 , 77 , 92 ]. The histologic subtype of the primary tumor is not an accurate predictor for the pattern of metastases[ 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review

Kanthan¹,

Tharmaradinam²,

Asif³

et al. 2020

WJG

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BACKGROUND Mixed tumors of the colon and rectum, composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms. These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally. Though they have been a well-documented entity in the pancreas, where the exocrine-endocrine mixed tumors have been known for a while, recognition and accurate diagnosis of these tumors in the colon and rectum, to date, remains a challenge. This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification. Therefore, dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers. Though, most of these tumors are high grade and of advanced stage, intermediate and low grade lesions of these mixed tumors are also increasingly been reported. There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions. AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape, clinicoradiological features, pathology, treatment, prognosis, the current status of the management of the primary lesions, their recurrences and metastases. METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed, MEDLINE and GOOGLE scholar. The following search terms [“mixed tumors colon” OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors] were used. Eligibility criteria were defined and all potential relevant items, including full articles and/or abstracts were independently reviewed, assessed and agreed upon items were selected for in-depth analysis. RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review. This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives, nomenclature, clinicoradiological features, pathology, treatment, prognosis and the current status of the management of both the primary lesions, their recurrences and metastases. Gaps in knowledge have also been identified and discussed. An important outcome of this manuscript is the justified prop...

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