Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects

Fabri, Rodrigo Luiz; Nogueira, Mauro S.; Braga, Fernanda Gambogi; Coimbra, Elaine Soares; Scio, Elita

doi:10.1016/j.biortech.2008.05.053

Cited by 51 publications

(31 citation statements)

References 28 publications

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“…The increase in antioxidant activity may be explained by the increase of solvent polarity. These results have been confirmed by other studies using the FRAP (Ardestani and Yazdanparast, 2007;Atmani, 2009;Li et al, 2009) and DPPH (Tian et al, 2009;Fabri et al, 2009) assays. Antioxidant and radical scavenging properties of plant extracts is associated with the presence of phenolic compounds which are able to donate hydrogen to the radical.…”

Section: Total Antioxidant Capacity (Tac)supporting

confidence: 85%

Antioxidant activity, phenolic and flavonoid content in leaves, flowers, stems and seeds of mallow (Malva sylvestris L.) from North Western of Algeria

Beghdad¹,

Benammar²,

Bensalah³

et al. 2014

Afr. J. Biotechnol.

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The nutraceutical composition (phenolics and flavonoids) of all leaves, flowers, stems and seeds of mallow, Malva sylvestris L., as well as their antioxidant properties were studied using in vitro methods: ferric reducing antioxidant power (FRAP) assay, by scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and total antioxidant capacity (TAC) based on the reduction of molybdenum (VI) to molybdenum (V). Results show that all extracts possessed concentration-dependant antioxidant activity. Leaf extracts have a highest amount of total phenolics with 24.123 ± 0.718 mg GAE/g, and total flavonoids with 0.694 ± 0.017 mg RE/100 g. However, the seed extracts presented the lowest amount in the two assays used. In addition, the AcOEt (EC 50 = 3.10 mg/ml) fraction showed the highest value of antioxidant activities for almost all parts of leaves.

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Section: Total Antioxidant Capacity (Tac)supporting

confidence: 85%

Antioxidant activity, phenolic and flavonoid content in leaves, flowers, stems and seeds of mallow (Malva sylvestris L.) from North Western of Algeria

Beghdad¹,

Benammar²,

Bensalah³

et al. 2014

Afr. J. Biotechnol.

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“…Three total syntheses of psychorubrin have also been reported (Kesteleyn et al 1999, Bulbule et al 2003, Nguyen and Kimpe 2004. been subjected to phytochemical investigation, except a recently published paper (Fabri et al 2009). …”

Section: Introductionmentioning

confidence: 99%

“…Upon the discovery of strong biological activity of the dichloromethane (CH 2 Cl 2 ) extract, the authors sought to isolate the compound or compounds responsible for this activity. Preparation of the crude CH 2 Cl 2 extract was previously described in detail (Fabri et al 2009). Purification of this extract was performed in the following manner: the CH 2 Cl 2 extract (4.8 g) was chromatographed on a 74 x 4 cm column of silica gel (70-230 mesh) with a gradient of increasing polarity (CH 2 Cl 2 , CH 2 Cl 2 -EtOAc, EtOAc, EtOAcMeOH, MeOH) to obtain a total of twenty fractions.…”

Section: Introductionmentioning

confidence: 99%

Antitumor, antibiotic and antileishmanial properties of the Pyranonaphthoquinone Psychorubrin from Mitracarpus frigidus

Fabri

Grazul

Carvalho

et al. 2012

An. Acad. Bras. Ciênc.

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The bioactivity guided fractionation of the dichloromethane extract of Mitracarpus frigidus afforded the pyranonaphthoquinone psychorubrin. This compound, hitherto unknown in the genus Mitracarpus, had its biological activity evaluated against one panel of bacteria and two fungi, three tumor cell lines (HL60, Jurkat and MCF-7) and four Leishmania species. Its identity was confirmed unambiguously by 1 H, 13 C, 1 H-COSY, IR and UV-Vis spectroscopy and mass spectrometry. Psychorubrin displayed a very promising antitumor with IC 50 of 4.5, 5.6 and 1.1 µM for HL60, Jurkat and MCF-7 cell lines, respectively. Antimicrobial activity, mainly against Cryptococcus neoformans (MIC of 87.3 µM) was observed. A pronounced antileishmanial potential was also verified with IC 50 varying from 1.7 to 2.7 µM for the Leishmania species tested. This is the first report of the presence of pyranonapthoquinones in the Mitracarpus genus, which may serve as a chemotaxonomical marker.

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“…Also, in our previous work, we showed that M. frigidus extracts had a significant antibacterial, antifungal and leishmanicidal activities (Fabri et al 2009). So, in order to increase our knowledge about M. frigidus, this work deals with the chemical composition and the in vitro activity against Gram-positive and Gram-negative bacteria and yeasts strains, promastigote forms of Leishmania species and cytotoxicity against Artemia salina of the essential oil of this specie.…”

Section: Introductionmentioning

confidence: 99%

“…

ABSTRACTIn our previous work (Fabri et al 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil.

…”

mentioning

confidence: 99%

Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds

Fabri

Coimbra

Almeida

et al. 2012

An. Acad. Bras. Ciênc.

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In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. frigidus was analyzed by GC/MS. Among several compounds detected, 11 were identified, being linalool and eugenol acetate the major components. The essential oil exhibited a moderate antibacterial effect against Staphyloccocus aureus, Bacillus cereus, Pseudomonas aeruginosa and Enterobacter cloacae (MIC 250 μg/mL). On the other hand, it showed a strong antifungal effect against Cryptoccocus neoformans (MIC 8 μg/mL) and Candida albicans (MIC 63 μg/mL). Expressive activity against L. major and L. amazonensis promastigote forms with IC 50 values of 47.2 and 89.7 μg/mL, respectively, were also observed. In addition, the antioxidant activity was investigated through DPPH radical-scavenging and showed a significative activity with IC 50 of 38 μg/mL. The cytotoxicity against Artemia salina was moderate with LC 50 of 88 μg/mL. The results presented here are the first report on the chemical composition and biological properties of M. frigidus essential oil.

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Mitracarpus frigidus aerial parts exhibited potent antimicrobial, antileishmanial, and antioxidant effects

Cited by 51 publications

References 28 publications

Antioxidant activity, phenolic and flavonoid content in leaves, flowers, stems and seeds of mallow (Malva sylvestris L.) from North Western of Algeria

Antioxidant activity, phenolic and flavonoid content in leaves, flowers, stems and seeds of mallow (Malva sylvestris L.) from North Western of Algeria

Antitumor, antibiotic and antileishmanial properties of the Pyranonaphthoquinone Psychorubrin from Mitracarpus frigidus

Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds

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