Mitotic instability associated with late genomic changes in bone and soft tissue tumours

Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability

“…29,30 However, similar to our findings in this study with giant cell tumour of bone, other malignant epithelial and benign and malignant mesenchymal tumours showed no correlation between centrosome number and the frequency of aneusomy. 31,7 We found that centrosome amplification was present in benign giant cell tumour of bone cases, which shows that this phenomenon is not characteristic of malignant giant cell tumour of bones. However, correlation with giant cell tumour of bone behaviour suggests that centrosome amplification may be useful in predicting the clinical behaviour of this tumour.…”

“…[4][5][6][7] The centrosome is a small cytoplasmic organelle consisting of paired centrioles and surrounding protein aggregates called pericentriolar material. The pericentriolar matrix is composed of a large series of proteins including pericentrin, g-tubulin and cell-cycle regulatory proteins.…”

Cell Lines Derived From Feline Fibrosarcoma Display Unstable Chromosomal Aneuploidy and Additionally Centrosome Number Aberrations

“…However, similar to our findings with feline fibrosarcomas, other malignant epithelial and mesenchymal tumors demonstrated no correlation of aneuploidy and amplification of centrosomes. 18,47 We concluded that numerical centrosome aberrations alone may not be responsible for the formation of aneuploidy in feline fibrosarcoma cell lines. In summary, we demonstrated the occurrence of aneuploidy associated with aberrations in centrosome number in 5 feline fibrosarcoma cell lines.…”

“…A relationship between aneuploidy and centrosome anomalies has also been reported in a number of tumor cell lines and in solid tumors in humans-for example, in cells of mammary carcinomas, carcinomas of the prostate, colon carcinomas, and hepatocellular carcinomas. 6,18,34,40,43 Also, precancerous tissue alterations, such as prostate hyperplasia or benign colon adenomas, revealed an association between aneuploidy and centrosome hyperamplification (>2 centrosomes per cell). 30,42,43 Chromosome studies provide a relevant approach to the understanding of tumor mechanisms.…”

Centrosome amplification in chondrosarcomas: A primary cell culture and cryopreserved tumor sample study

“…The majority of genetic analyses performed on CS were performed on a heterogeneous group that included all different subtypes of CS; ploidy-analysis of CS has been described and aneuploidy is more frequently found in high-grade CS (7,8).…”