Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability

A Clinical Overview of Centrosome Amplification in Human Cancers

“…The degree of CA is also significantly higher in recurrent and malignant cases than in non-recurrent cases of giant cell tumour of bone 167, in which a positive correlation exists between aneuploidy and CA. Interestingly, benign or tumour-like lesions of soft tissue may also feature CA, albeit at lower frequencies 164-166.…”

“…CA has been detected in various types of malignant and borderline malignant sarcomas, including osteosarcoma, chondrosarcoma, malignant fibrous histiocytoma (MFH), haemangiopericytoma, atypical lipomatous tumour, liposarcoma, giant cell tumour, peripheral PNET, synovial sarcoma, rhabdomyosarcoma, leiomyosarcoma as well as malignant peripheral nerve sheath tumour (MPNST) 162-167. In several types of sarcomas, aneuploid karyotypes are strongly associated with supernumerary centrosomes and multipolar mitoses, as well as anaphase bridges.…”

Centrosome amplification in chondrosarcomas: A primary cell culture and cryopreserved tumor sample study

“…Another case exhibited a low rate of centrosome amplification, showing only 15% of cells with amplification. This finding is not unexpected, as centrosome amplification in bone and soft tissue tumors has been observed in tumors classified as benign or with local aggressiveness (as in giant cell tumors) or even in malignant bone tumors such as osteosarcoma (14).…”

“…Moskovsky et al reported that centrosome amplification is present in benign giant cell tumors of the bone, demonstrating that this phenomenon is not characteristic of malignant giant cell tumors. In addition, the study showed that centrosome amplification was prognostic for clinical behavior (14). The present study aimed to characterize centrosome amplification in CS using cryopreserved tissue samples and tissue cultures.…”

The evolution of primary hyperparathyroidism

“…A molecular basis for extra-increased osteoclastic activation at such locations might be inferred from the study of non-PHPT related giant cell tumors of bone (GCTB), in which somatic chromosomal instability and overexpression of RANK pathway elements have been implicated (8,9).…”