Mitotic Arrest of Endometrial Epithelium After Paclitaxel Therapy for Breast Cancer

Irving, Julie; McFarland, D F; Stuart, David; Gilks, C. Blake

doi:10.1097/00004347-200010000-00018

Cited by 16 publications

(8 citation statements)

References 6 publications

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“…Paclitaxel, an MT-stabilizing drugs, induces marked morphologic effect with mitotic arrest in the endometrium (Irving et al 2000). We have recently observed that the treatment with vinblastine or colchicines (MT disrupting drugs) at the concentration between 1 and 100 pM decreased the cAMP-induced IGFBP-1 secretion without changes in cell viability (data not shown).…”

Section: Poly(a)mentioning

confidence: 97%

Expression of stathmin in human uterus and decidualizing endometrial stromal cells

Tamura¹,

Yoshie²,

Nishi³

et al. 2006

Reproduction

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The cytosolic phosphoprotein stathmin is upregulated at the site of embryo implantation in the rodents. However, stathmin expression in the human uterus has not yet been investigated. The distribution of uterine and placental stathmin was analyzed by immunohistochemistry, while stathmin mRNA expression was detected in endometrial tissues by the reverse transcriptase-PCR. Cultured endometrial stromal cells were used to investigate whether stathmin plays a role in decidualization. Stathmin is expressed specifically in the glandular epithelium and the stromal cells of human endometrial tissue. It is also expressed by cytotrophoblasts and extravillous trophoblasts, but not by syncytiotrophoblasts or decidual tissues during the first trimester of pregnancy. When stromal cells isolated from normal endometrial tissues were cultured and stimulated to decidualize by progesterone (P4) plus estrogen or dibutyryl cyclic 3 0 ,5 0 -AMP, their total and phosphorylated stathmin levels decreased. Knocking down stathmin expression in the cultured stromal cells using small interfering RNA, before the cells were exposed to the decidualizing agents, significantly suppressed decidualization, as indicated by the decreased expression of IGF-binding protein-1 and prolactin. Stathmin is differently expressed in human endometrial and placental cells and may participate in the decidualization of endometrial stromal cells.

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Section: Poly(a)mentioning

confidence: 97%

Expression of stathmin in human uterus and decidualizing endometrial stromal cells

Tamura¹,

Yoshie²,

Nishi³

et al. 2006

Reproduction

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“…Subsequent reviews further characterized these changes, and noted a high incidence of ring‐shaped mitotic figures, along with epithelial changes mimicking dysplasia . Similar findings have been described in endometrial epithelium . Such morphologic features are thought to be intrinsically related to the anti‐proliferative effects of taxanes, which function by stabilizing microtubule polymers and arresting cells within metaphase, preventing completion of cell division and triggering apoptosis .…”

Section: Discussionmentioning

confidence: 60%

Intravesicular taxane‐induced dermatotoxicity in a 78‐year‐old man with urothelial carcinoma and primary cutaneous anaplastic large cell lymphoma

et al. 2018

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Patients treated with intravesical bacillus Calmette-Guérin therapy for urothelial carcinoma often become refractory and experience recurrent disease, thus necessitating alternative intravesical treatment modalities if the patient is to be spared the morbidities associated with radical cystectomy. Intravesical treatment with taxane-based chemotherapy, such as docetaxel, has gained traction in urologic oncology, proving to be an effective salvage therapy in such patients. Systemic taxane-based chemotherapeutic regimens have long been used in several advanced malignancies, and their systemic side-effects and associated histologic correlates have been extensively documented. In contrast to adverse effects associated with systemic administration, intravesical taxane administration has thus far proven to be well-tolerated, with little to no systemic absorption. To our knowledge, features of taxane-induced systemic effects have not been reported in this setting. Herein, we report a case of a patient with recurrent urothelial carcinoma treated with intravesical docetaxel, along with primary cutaneous anaplastic large cell lymphoma, who developed characteristic dermatotoxic histologic findings associated with intravenous taxane administration. As such histopathologic findings often represent close mimickers of neoplastic and infectious etiologies, knowledge of the potential for systemic manifestations of taxane therapy in patients treated topically may prevent potentially costly diagnostic pitfalls.

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“…Taxanes act by the simultaneous promotion of tubulin assembly into microtubules and inhibition of microtubule disassembly. In the endometrium, taxane therapy may result in numerous mitoses in metaphase arrest with the formation of ring mitoses 25. Similar morphological changes are seen in other organs, such as the gastrointestinal tract, in association with taxanes.…”

Section: Chemotherapy Induced Changesmentioning

confidence: 74%

Iatrogenic lesions and artefacts in gynaecological pathology

Clarke

McCluggage²

2008

J Clin Pathol

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Increasingly in the field of medicine, new therapeutic modalities, both surgical and non-surgical, are being introduced. Some of these may significantly alter the pathological appearance of normal and neoplastic tissue and result in problems for the pathologist. In this review, iatrogenic pathology within the female genital tract is described, especially concentrating on the recent literature. Pathological artefacts within the female genital tract are also reviewed. Topics covered include mechanical displacement of normal and neoplastic elements into vascular or tissue spaces and thermal artefacts. Recently described pathological findings in neoplastic and non-neoplastic tissue secondary to hormonal, chemotherapeutic and other medications are discussed. Changes associated with non-surgical management of uterine leiomyomas are also described. It behoves the pathologist to be aware of these iatrogenic lesions and artefacts in order to prevent diagnostic errors.

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Mitotic Arrest of Endometrial Epithelium After Paclitaxel Therapy for Breast Cancer

Cited by 16 publications

References 6 publications

Expression of stathmin in human uterus and decidualizing endometrial stromal cells

Expression of stathmin in human uterus and decidualizing endometrial stromal cells

Intravesicular taxane‐induced dermatotoxicity in a 78‐year‐old man with urothelial carcinoma and primary cutaneous anaplastic large cell lymphoma

Iatrogenic lesions and artefacts in gynaecological pathology

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