Mitomycin C in Revision Endoscopic Dacryocystorhinostomy: A Prospective Randomized Study

Penttilä, Elina; Смирнов, Г. А.; Seppä, Juha; Tuomilehto, Henri

doi:10.2500/ajra.2011.25.3676

Cited by 38 publications

(31 citation statements)

References 40 publications

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“…One study was divided into two comparative groups as it included both primary and revision DCRs. Three studies were done in India [12], [13], [33], 3 in Turkey [11], [30], [32], and 1 each in Iran [15], Finland [34], Egpty [35], Thailand [14], and China [10]. The mean age of patients in most of studies ranged from 32 to 70 years and the percentage of female patients ranged from 42% to 90%.…”

Section: Resultsmentioning

confidence: 99%

“…In 5 of all the RCTs included in the systematic review, the investigators described a random component in the sequence generation process such as: referring to a random number table [13] or using a computer random number generator [11], [34] or using a random blocks [14], [35]. The remainder did not describe the specific methods of random sequence generation.…”

Section: Resultsmentioning

confidence: 99%

“…The results are as follows: Subgroup 1 (primary EN-DCR, eight studies [10], [12]–[15], [31]–[33], recruiting 420 eyes) [RR = 1.09, 95% CI (1.00, 1.18), P = 0.045; Figure 4]; Subgroup 2 (revision EN-DCR, four studies [11], [31], [34], [35], recruiting 144 eyes) [RR = 1.21, 95% CI (1.02, 1.45), P = 0.029; Figure 4]; Subgroup 3 (EN-DCR without silicone intubation, six studies [10], [12], [13], [32]–[34], recruiting 285 eyes) [RR = 1.15, 95% CI (1.03, 1.27), P = 0.010; Figure 5]; Subgroup 4 (EN-DCR with silicone intubation, five studies [11], [14], [15], [31], [35], recruiting 289 eyes) [RR = 1.09, 95% CI (0.98, 1.21), P = 0.122; Figure 5]. All the results indicated that MMC group had a higher success rate except the subgroup of EN-DCR with silicone intubation.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis

Cheng

Feng

et al. 2013

PLoS ONE

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BackgroundA number of published comparative studies have been conducted to evaluate the efficacy and safety of intraoperative mitomycin C (MMC) in endoscopic dacryocystorhinostomy (EN-DCR). However, results have not always been consistent. Therefore, we carried out a meta-analysis to compare the clinical results of EN-DCR with and without MMC.Methods and FindingsA comprehensive literature search of Cochrane Library, PubMed and EMBASE to identify relevant trials comparing EN-DCR with and without MMC. Eleven studies including 574 eyes were included in this meta-analysis. The success was defined as patency of the nasolacrimal canal and symptomatic improvement. There was significantly higher success rate in the MMC group in comparison with control group [RR = 1.12, 95% CI (1.04, 1.20), P = 0.004]. A sensitivity analysis after the non-randomized controlled trials were excluded from the meta-analysis demonstrated no differences compared with the overall results. Subgroup analyses showed that MMC group had a significantly higher success rate than control group in primary and revision EN-DCR, and EN-DCR without silicone intubation, but no difference in the subgroup of with silicone intubation. The size of the osteotomy site was bigger in the MMC group compared to the control group at 3 months [WMD = 7.65, 95% CI (0.33, 14.98), P = 0.041] and 6 months [WMD = 9.28, 95% CI (2.45, 16.11), P = 0.008] after surgery. However, there was statistically significant difference in the osteotomy surface area between the two groups at 12 months after surgery [WMD = 11.63, 95% CI (−1.04, 24.29), P = 0.072].ConclusionIntraoperative MMC application seems to be a safe adjuvant that could reduce the closure rate of the osteotomy and enhance the success rate after both primary and revision EN-DCR.Trial RegistrationClinicalTrials.gov NCT01772277

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis

Cheng

Feng

et al. 2013

PLoS ONE

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“…They used, at the end of the revision procedure, a piece of tampon soaked in mmc (0.4 mg/mL) which was placed into the rhinostoma for 5 minutes. Therefore the authors suggested the application of intraoperative mmc to improve the outcome in revision endoscopic dacryocystorhinostomy [19]. Vascularity plays a big role in healing.…”

Section: Resultsmentioning

confidence: 99%

The Success Rate of Endocanalicular Laser Dacryocystorhinostomy with Two Different Mitomycin-C Application

Altay¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Endokanaliküler multidiod lazer dakriyosistorinostomi (ECL-DCR) operasyonlarında farklı iki mitomisin-c (mmc) uygulamasının başarı oranlarının belirlenmesi. Gereç ve Yöntem: ECL-DCR ameliyatı uygulanan primer akkiz nazolakrimal kanal tıkanıklığı olan 89 hasta üzerinde prospektif ve karşılaş-tırmalı çalışma yapıldı. Grup 1 de 44 hastaya ECL-DCR ameliyatı ve intraoperatif 0.4 mg/ml mmc 2 dakika süreyle, Grup 2 de 45 hastaya ECL-DCR ameliyatı ve intraoperatif 0.4 mg/ml mmc 5 dakika süreyle uygulandı. Hastalar en az 12 ay takip edildi. Epiforanın düzelmesi ve irrigasyonda nazolakrimal kanal açıklığı başarı kriteri olarak kabul edildi. Bulgular: Grup 1 de 44 hastanın 26 sında (%59.1), grup 2 de 45 hastanın 36 sında (%80) başarı elde edildi. Gruplar arasındaki fark istatistiksel olarak anlamlıydı (Ki-kare, p=0.03). Tartışma: Diod lazer ECL-DCR operasyonu, intraoperatif 0.4 mg/ml mmc 5 dakika uygulaması, primer nazolakrimal kanal tıkanıklığının tedavisinde etkili bir yön-tem olarak görünmektedir. Anahtar KelimelerEndokanaliküler Multidiod Lazer Dakriyosistorinostomi; Mitomisin-C; Nazolakrimal Kanal Tıkanıklığı Abstract Aim: To determine the success rate of different application of mitomycin-c (mmc) in endocanalicular multidiode laser dacryocystorhinostomy (ECL-DCR). Material and Method: A prospective comparative study was conducted on 89 patients with primary acquired nasolacrimal duct obstruction, undergoing ECL-DCR procedures. Group 1 was composed of 44 patients undergoing ECL-DCR with intraoperative 0.4 mg/ml mmc application for 2 minutes and group 2 was composed of 45 patients undergoing ECL-DCR with intraoperative 0.4 mg/ml mmc application for 5 minutes. Patients were followed up for at least 12 months.The main outcome measure for success was resolution or improvement of epiphora and patency of nasolacrimal duct with irrigation. Results: Final success was 26/44(%59.1) for group 1, and 36/45 (%80) for group 2.The difference was statistically significant (Chi-siquare, p=0.03). Discussion: Diode laser ECL-DCR with 0.4 mg /ml intraoperative mmc application for 5 minutes appears to be an effective treatment modality for primary nasolacrimal duct obstruction.

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“…Some studies have reported very promising results. [12][13][14][15] But other studies have shown that use of mitomycin C at the operative site did not improve success rate significantly. [13] We used a topical 0.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic DCR a Comparative Study Between Conventional Mucosal Flap, Mitomycin C Application and Silicone Stenting

Saini¹,

Pathania²,

Kaur³

et al. 2015

jebmh

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BACKGROUND/OBJECTIVES: Recurrent stenosis and closure of neostium is considered a major factor for surgical failure in endoscopic dacryocystorhinostomy (Endo DCR). The main objective of this study is to evaluate the role of mitomycin c and silicone stent in maintaining the patency of the neostium. MATERIALS AND METHODS: Endo DCR were done in 180 patients. Group A included 40 patients where only mucosal flap was created, group B included 40 patients where silicon tube stents were used. Group C 40 included those in whom mitomycin c was applied to the neo ostium. Group D 40 included those in whom stenting along with mitomycin c was used. All the surgeries were done under general anaesthesia. RESULTS: In our study, 90% success in syringing patency was seen in group A, 85% success in syringing patency was seen in group B at 6 months of follow-up. 95% success was seen in group C. 100% success rate was seen in patients with mitomycin c application and stenting. Significant difference in success rate was seen group D. CONCLUSION: Significant difference in EDCR success rates were seen with the use of mitomycin c along with stenting in our study.

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Mitomycin C in Revision Endoscopic Dacryocystorhinostomy: A Prospective Randomized Study

Abstract: The results of our study indicate that the application of intraoperative mitomycin C may improve the outcome in revision EN-DCR.

Cited by 38 publications

References 40 publications

Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis

Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis

The Success Rate of Endocanalicular Laser Dacryocystorhinostomy with Two Different Mitomycin-C Application

Endoscopic DCR a Comparative Study Between Conventional Mucosal Flap, Mitomycin C Application and Silicone Stenting

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