Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

Wen, Ru; Umeano, Afoma; Francis, Lily; Sharma, Nivita; Tundup, Smanla; Dhar, Shanta

doi:10.3390/vaccines4020018

Cited by 15 publications

(7 citation statements)

References 194 publications

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“…In addition to increase of ROS production, more interestingly, photodynamically induced mitochondrial apoptosis induces signal transduction pathways, which also participate in the development of immune responses [ 86 ]. Marrache et al reported their study regarding the use of mitochondria-targeted-nanoparticle delivery systems to deliver mitochondria-acting photosensitizer for generation of tumor cell antigens to activate DCs ex vivo for potential immune response.…”

Section: Future Perspectives Of Improving Anticancer Immune Responmentioning

confidence: 99%

Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

Yang

Wang

2016

Oxidative Medicine and Cellular Longevity

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Photodynamic therapy (PDT) is a minimally invasive therapeutic strategy for cancer treatment, which can destroy local tumor cells and induce systemic antitumor immune response, whereas, focusing on improving direct cytotoxicity to tumor cells treated by PDT, there is growing interest in developing approaches to further explore the immune stimulatory properties of PDT. In this review we summarize the current knowledge of the innate and adaptive immune responses induced by PDT against tumors, providing evidence showing PDT facilitated-antitumor immunity. Various immunotherapeutic approaches on different cells are reviewed for their effectiveness in improving the treatment efficiency in concert with PDT. Future perspectives are discussed for further enhancing PDT efficiency via intracellular targetable drug delivery as well as optimized experimental model development associated with the study of antitumor immune response.

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Section: Future Perspectives Of Improving Anticancer Immune Responmentioning

confidence: 99%

Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

Yang

Wang

2016

Oxidative Medicine and Cellular Longevity

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“…Various types of nanoparticles can be used as delivery systems or as adjuvants, such as polymeric nanoparticles, liposomes, micelles, carbon nanotubes, mesoporous silica nanoparticles (MSNs), gold nanoparticles (AuNPs), virus nanoparticles, acting alone or in combination ( Figure 1) [28]. Adding specific surface targeting moieties can significantly enhance delivery and hone nanoparticles to specific subcellular organelles involved in immune response [29][30][31][32][33]. Active vaccine systems can be formulated by incorporating cell-penetrating peptides, APC-specific cellular epitopes or immune-stimulant lipid moieties [34].…”

Section: Nanoparticles As Vaccine Delivery Systemsmentioning

confidence: 99%

Nanoparticle Systems for Cancer Vaccine

Wen

Umeano

Kou

et al. 2019

Nanomedicine (Lond.)

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103

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As effective tools for public health, vaccines prevent disease by priming the body's adaptive and innate immune responses against an infection. Due to advances in understanding cancers and their relationship with the immune system, there is a growing interest in priming host immune defenses for a targeted and complete antitumor response. Nanoparticle systems have shown to be promising tools for effective antigen delivery as vaccines and/or for potentiating immune response as adjuvants. Here, we highlight relevant physiological processes involved in vaccine delivery, review recent advances in the use of nanoparticle systems for vaccines and discuss pertinent challenges to viably translate nanoparticle-based vaccines and adjuvants for public use.

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“…To achieve mitochondrial‐targeting drug delivery, various nanoparticles are decorated with targeting ligands, especially triphenylphosphonium (TPP), which has the advantages of simple purification and modification. [ 24 ] Molecules are easily and precisely accumulated in the mitochondrial matrix through the lipid bilayer on account of their lipophilic and hydrophilic properties with TPP modification. [ 25 ] Therefore, an excellent mitochondrial‐targeting nanoparticle should be silent in blood circulation or normal tissues and activated once entering tumors.…”

Section: Introductionmentioning

confidence: 99%

NIR‐II Imaging‐Guided Mitochondrial‐Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy

Yang

Sun

Liu

et al. 2023

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Effectively interfering energy metabolism in tumor cells and simultaneously activating the in vivo immune system to perform immune attacks are meaningful for tumor treatment. However, precisely targeted therapy is still a huge challenge. Herein, a mitochondrial‐targeting phototheranostic system, FE‐T nanoparticles (FE‐T NPs) are developed to damage mitochondria in tumor cells and change the tumor immunosuppressive microenvironment. FE‐T NPs are engineered by encapsulating the near‐infrared (NIR) absorbed photosensitizer IR‐FE‐TPP within amphiphilic copolymer DSPE‐SS‐PEG‐COOH for high‐performing with simultaneous mitochondrial‐targeting, near‐infrared II (NIR‐II) fluorescence imaging, and synchronous photothermal therapy (PTT) /photodynamic therapy (PDT) /immune therapy (IMT). In tumor treatment, the disulfide in the copolymer can be cleaved by excess intracellular glutathione (GSH) to release IR‐FE‐TPP and accumulate in mitochondria. After 808 nm irradiation, the mitochondrial localization of FE‐T NPs generated reactive oxygen species (ROS), and hyperthermia, leading to mitochondrial dysfunction, photoinductive apoptosis, and immunogenic cell death (ICD). Notably, in situ enhanced PDT/PTT in vivo via mitochondrial‐targeting with FE‐T NPs boosts highly efficient ICD toward excellent antitumor immune response. FE‐T NPs provide an effective mitochondrial‐targeting phototheranostic nanoplatform for imaging‐guided tumor therapy.

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Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

Cited by 15 publications

References 194 publications

Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

Targeting Antitumor Immune Response for Enhancing the Efficacy of Photodynamic Therapy of Cancer: Recent Advances and Future Perspectives

Nanoparticle Systems for Cancer Vaccine

NIR‐II Imaging‐Guided Mitochondrial‐Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy

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