2015
DOI: 10.21767/2171-6625.100017
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Mitochondrial Targeted Antioxidant in Cerebral Ischemia

Abstract: There has been much evidence suggesting that reactive oxygen species (ROS) generated in mitochondria during cerebral ischemia play a major role in programming the senescence of organism. Antioxidants dealing with mitochondria slow down the appearance and progression of symptoms in cerebral ischemia and increase the life span of organisms. The mechanisms of mitochondrial targeted antioxidants, such as SKQ1, Coenzyme Q10, MitoQ, and Methylene blue, include increasing adenosine triphosphate (ATP) production, decr… Show more

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Cited by 31 publications
(20 citation statements)
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“…Coenzyme Q10 (CoQ10) is a mitochondrial targeted antioxidant that plays an essential role in the normal function of the electron transport chain. CoQ10 has been reported to exhibit neuroprotective activity in a range of disorders including; cerebral ischemia, ( Ahmed et al, 2015 ) Parkinson's disease and Huntington's disease ( Klongpanichapak et al, 2006 ). In addition to its role as an antioxidant, CoQ10 is also reported to protect against glutamate excitotoxicity in vivo through the inhibition of mitochondrial depolarization ( Papucci et al, 2003 , Lee et al, 2014b ).…”
Section: Introductionmentioning
confidence: 99%
“…Coenzyme Q10 (CoQ10) is a mitochondrial targeted antioxidant that plays an essential role in the normal function of the electron transport chain. CoQ10 has been reported to exhibit neuroprotective activity in a range of disorders including; cerebral ischemia, ( Ahmed et al, 2015 ) Parkinson's disease and Huntington's disease ( Klongpanichapak et al, 2006 ). In addition to its role as an antioxidant, CoQ10 is also reported to protect against glutamate excitotoxicity in vivo through the inhibition of mitochondrial depolarization ( Papucci et al, 2003 , Lee et al, 2014b ).…”
Section: Introductionmentioning
confidence: 99%
“…Under normal circumstances, there is a balance between ROS generation and the endogenous antioxidant systems in the cell. However, ischemia and reperfusion disturb the balance of the endogenous antioxidant system, which increases oxidative stress by the overproduction of cellular ROS and ultimately leads to neuronal death 1921. SOD, CAT and GSH-PX, as the endogenous antioxidant enzymes, are believed to play vital roles in the defense mechanisms against free radical-induced oxidative stress 22,23.…”
Section: Discussionmentioning
confidence: 99%
“…Coenzyme Q10 (CoQ10) is a mitochondrial targeted antioxidant that plays an essential role in the normal function of the electron transport chain. CoQ10 has been reported to have neuroprotective activity in neurodegenerative diseases and cerebral ischemia [81]. In addition to its antioxidant function, CoQ10 is also reported to protect against glutamate excitotoxicity [82].…”
Section: Oxidative Stress and Mitochondrial Dysfunctionmentioning
confidence: 99%