Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study

Mahjabeen, Ishrat; Rizwan, Muhammad; Fareen, Gul; Ahmed, Malik Waqar; Khan, Amir Farooq; Kayani, Mahmood Akhtar

doi:10.1016/j.gene.2021.145951

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…The increase in SIRT enzyme activity does not always correlate with lifespan, although the Kaplan-Meier analysis demonstrates an association between increased activity of these enzymes and extended life. While heightened enzyme activity may contribute to favorable effects, excessive elevation could have adverse consequences [4,41]. In the context of our obtained results, the cellular parameters appear consistent because these suggest that the treatments have a time-dependent effect on the strains, with the NDs treatment showing a particularly dynamic response in the D strain.…”

Section: Is There a Correlation Between The Age Of Acheta Domesticus ...supporting

confidence: 77%

Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?

Ziętara,

Flasz,

Augustyniak

2024

IJMS

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Sirtuins, often called “longevity enzymes”, are pivotal in genome protection and DNA repair processes, offering insights into aging and longevity. This study delves into the potential impact of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, focusing on two strains of house crickets (Acheta domesticus): the wild-type and long-lived strains. The general sirtuin activity was measured using colorimetric assays, while fluorescence assays assessed SIRT1 activity. Additionally, a DNA damage test and a Kaplan–Meier survival analysis were carried out. Experimental groups were fed diets containing either NDs or RV. Notably, the long-lived strain exhibited significantly higher sirtuin activity compared to the wild-type strain. Interestingly, this heightened sirtuin activity persisted even after exposure to RVs and NDs. These findings indicate that RV and NDs can potentially enhance sirtuin activity in house crickets, with a notable impact on the long-lived strain. This research sheds light on the intriguing potential of RV and NDs as sirtuin activators in house crickets. It might be a milestone for future investigations into sirtuin activity and its potential implications for longevity within the same species, laying the groundwork for broader applications in aging and lifespan extension research.

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Section: Is There a Correlation Between The Age Of Acheta Domesticus ...supporting

confidence: 77%

Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?

Ziętara,

Flasz,

Augustyniak

2024

IJMS

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“…Increased LDHA levels in GC patients correlate with better response to chemotherapy and unfortunately also with shorter overall survival [ 81 ]. Recent research showed that genetic polymorphisms of mitochondrial sirtuins, including SIRT3, are linked to GC pathogenesis [ 104 ]. Changes that involve these genes lead to mitochondrial dysfunctions, thus promoting carcinogenesis.…”

Section: Role Of Sirtuins (Sirts) In Progression and Metastasis Of Gc...mentioning

confidence: 99%

Sirtuins (SIRTs) As a Novel Target in Gastric Cancer

Poniewierska-Baran

Warias

Zgutka

2022

IJMS

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Gastric cancer is a major health burden worldwide. Among all neoplasms, gastric cancer is the fifth most common and the third most deadly type of cancer. It is known that sirtuins (SIRTs), are NAD+-dependent histone deacetylases regulating important metabolic pathways. High expression of SIRTs in the human body can regulate metabolic processes; they prevent inflammation but also resist cell death and aging processes. The seven members of this family enzymes can also play a fundamental role in process of carcinogenesis by influencing cell viability, apoptosis and metastasis. This review collects and discusses the role of all seven sirtuins (SIRT1–SIRT7) in the pathogenesis of gastric cancer (GC).

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“…A growing body of experimental evidence has implicated SIRTs in the regulation of pivotal cellular processes involved in cancer initiation and progression [ 14 , 15 , 16 , 17 , 106 ]. Although their expression is quite variable among tumor types and may act either as tumor suppressors or promoters depending on the cellular context, some SIRTs have shown clinical relevance with prognostic significance, biomarker potential, and association with drug resistance [ 14 , 15 , 16 , 17 ]. Emerging data have also implicated SIRTs in various aspects of glioma tumorigenesis, including proliferation, apoptosis, autophagy, stemness, angiogenesis, and metastasis, and are discussed in the following sections.…”

Section: Evidence Of Sirts Implication In Gb Pathogenesismentioning

confidence: 99%

“…Eighteen HDACs have been identified thus far and classified into four classes [ 9 ]. Class III HDACs, also known as sirtuins (SIRTs) were originally investigated as potential therapeutic targets in age-related and neurodegenerative diseases [ 10 , 11 ], inflammatory disorders [ 12 ], muscular diseases [ 13 ], and recently, in different cancer types [ 14 , 15 , 16 , 17 ], including GB. The role of SIRTs as regulators of gliomagenesis is currently under thorough research with significant data.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Multi-Faceted Role of Sirtuins in Glioblastoma Pathogenesis and Targeting Options

Kunadis

Piperi

2022

IJMS

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Recent advances in glioblastoma (GB) research have shed light on the molecular characteristics, the defected intracellular signaling pathways, and the genetic and epigenetic alterations involved in their pathogenesis. Despite constant efforts, GB remains an aggressive malignant tumor with limited therapeutic approaches, poor prognosis, and a low survival rate. Emerging evidence points towards the crucial impact of epigenetic post-translational modifications in cancer development with emphasis on the regulatory role of histone deacetylation in several key cellular processes, including metabolic pathways, regulation of stress response, senescence, proliferation, DNA repair, and apoptosis. The silent information regulator proteins (Sirtuins) are deacetylases of histone and non-histone proteins that have been recently implicated in the initiation as well as in the progression of GB. Herein, we provide a critical overview of the emerging functional role and mechanism of action of the seven Sirtuins (SIRT1-7) in GB and discuss their potential targeting options in clinical practice.

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Mitochondrial sirtuins genetic variations and gastric cancer risk: Evidence from retrospective observational study

Cited by 8 publications

References 49 publications

Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?

Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?

Sirtuins (SIRTs) As a Novel Target in Gastric Cancer

Exploring the Multi-Faceted Role of Sirtuins in Glioblastoma Pathogenesis and Targeting Options

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