Mitochondrial energy metabolism impairment and liver dysfunction following chronic exposure to dichlorvos

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

“…Since, there are limited data about the hepatotoxicity of OPs in humans, it is not certain whether changes in biochemical parameters indicate actual liver damage. (90)(91)(92)(93)(94), energy production (93,(95)(96)(97), and cell death (98)(99)(100). Several studies have found an association between mitochondrial dynamics and malathion-induced drop in mitochondrial ATP synthesis in rat liver (9) or quinalphos and acephate effects on liver succinic dehydrogenase (84,85,101) and ATPase activities (87) -all of them the key enzymes for oxidative phosphorylation.…”

“…Several studies have found an association between mitochondrial dynamics and malathion-induced drop in mitochondrial ATP synthesis in rat liver (9) or quinalphos and acephate effects on liver succinic dehydrogenase (84,85,101) and ATPase activities (87) -all of them the key enzymes for oxidative phosphorylation. Two studies in rats (90,93) point to an OP-induced drop in the liver mitochondrial respiratory control ratio (RCR), especially by dichlorvos. This decline may be related to changes in the inner mitochondrial membrane permeability caused by lipid peroxidation.…”

Dichlorvos Exposure Aggravates Complications Associated with Diabetes in Wistar Rats

“…Reactive oxygen species (ROS) have been implicated in DDVP toxicity potentially leading to liver dysfunction [47]. Liver is an organ of metabolism and detoxification and it is known to be a target for toxic agents.…”

Toxicological studies for some agricultural waste extracts on mosquito larvae and experimental animals

“…Moreover, fenitrothion and dichlorvos are a contactacting organophosphate insecticide which inhibits acetylcholinesterase activity, thus disrupting the nervous system [24][25][26][27][28] . The pattern of cholinesterase inhibition was in good agreement with the probable runoff of pesticides from agricultural fields [29,30] .…”

“…Binukumar et al [31] studies provide an evidence of impaired mitochondrial bioenergetics which may lead to liver dysfunction after chronic exposure to organophosphate pesticide dichlorvos.…”