Mitochondrial dysfunction and kidney disease

Dalbhi, Sultan K Al; Alqarni, Fatimah; Bahatheq, Nawaf Messad; Alrasheed, Reem Saleh; Alkhowaiter, Rufaydah Ali; Alnughaimshi, Areej Abdulaziz

doi:10.15171/jnp.2019.18

Cited by 3 publications

(5 citation statements)

References 57 publications

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“…Chronic inflammation, oxidative stress, and changes in cellular energy metabolism participate in reduced kidney function [11][12][13]. Mitochondrial dysfunction and reduced CoQ 10 concentration contribute to dysfunctional platelet activity in diseases, such as neurological diseases, cardiovascular diseases, diabetes mellitus, sepsis, Alzheimer's disease, Parkinson's disease, and chronic kidney disease [5,[14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

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Platelet Mitochondrial Respiration, Endogenous Coenzyme Q10 and Oxidative Stress in Patients with Chronic Kidney Disease

et al. 2020

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Chronic kidney disease (CKD) is characterized by a progressive loss of renal function and a decrease of glomerular filtration rate. Reduced mitochondrial function, coenzyme Q10 (CoQ10), and increased oxidative stress in patients with CKD contribute to the disease progression. We tested whether CoQ10 levels, oxidative stress and platelet mitochondrial bioenergetic function differ between groups of CKD patients. Methods: Twenty-seven CKD patients were enrolled in this trial, 17 patients had arterial hypertension (AH) and 10 patients had arterial hypertension and diabetes mellitus (AH and DM). The control group consisted of 12 volunteers. A high-resolution respirometry (HRR) method was used for the analysis of mitochondrial bioenergetics in platelets, and an HPLC method with UV detection was used for CoQ10 determination in platelets, blood, and plasma. Oxidative stress was determined as thiobarbituric acid reactive substances (TBARS). Results: Platelets mitochondrial respiration showed slight, not significant differences between the groups of CKD patients and control subjects. The oxygen consumption by intact platelets positively correlated with the concentration of CoQ10 in the platelets of CKD patients. Conclusion: A decreased concentration of CoQ10 and oxidative stress could contribute to the progression of renal dysfunction in CKD patients. The parameters of platelet respiration assessed by high-resolution respirometry can be used only as a weak biological marker for mitochondrial diagnosis and therapy monitoring in CKD patients.

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Section: Discussionmentioning

confidence: 99%

“…As an antioxidant, CoQ 10 quenches free radicals and directly prevents lipid peroxidation [9]. Different studies have demonstrated that platelet mitochondrial dysfunction has also been used for studying mitochondria-related diseases [10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Platelet Mitochondrial Respiration, Endogenous Coenzyme Q10 and Oxidative Stress in Patients with Chronic Kidney Disease

et al. 2020

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“…The human kidney comprises multiple cell populations that are involved in the maintenance of body homeostasis through processes such as blood pressure regulation, nutrient reabsorption, acid-base and electrolyte balance, and hormone secretion (4). Mitochondrial dysfunction is recognized as a leading factor in many renal diseases, including both acute and chronic or end stage renal disease (ESRD) (3,5).…”

Section: Mitochondrial Nephropathiesmentioning

confidence: 99%

“…Mitochondrial dysfunction is implicated in many neurological and muscular phenotypes as well as in diseases of other organ systems including the liver, gastrointestinal tract, heart, and kidneys (2,3).…”

Section: Introductionmentioning

confidence: 99%

Kidney manifestations of mitochondrial disorders

Gazdíková¹,

Fojtova²,

Ticha³

2022

BLL

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Mitochondria are intracellular organelles involved in a number of key biologic processes in the cell, including energy production, redox signaling, calcium homeostasis, infl ammation, senescence, innate immune response, and mitophagy. Mitochondrial cytopathies include a heterogeneous group of diseases that are characterized by impaired oxidative phosphorylation, leading to multi-organ involvement and progressive clinical deterioration. Mitochondrial cytopathies can result from mitochondrial or nuclear DNA mutations. Mitochondrial defects play an important role in the pathogenesis of nephropathies as tubular syndromes, interstitial nephritis, focal and segmental glomerulosclerosis and diabetic nephropathy. The role of mitochondria in a pathogenesis of nephrotoxicity and kidney carcinogenesis is also discussed (Tab. 2, Fig. 7, Ref. 100).

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“…The mitochondrial dysfunction in the kidney decreased the CoQ 10 level and oxidative stress plays critical roles in the pathogenesis of kidney diseases (33,34). The progression of the disease contributes to changes in cellular energy metabolism, dysfunctional kidney mitochondria (9, 10) and reduced antioxidant protection of the organism (5,26,33,34,35,36,37). In patients suffering from CKD stages 2 and 3, the impaired mitochondrial respiration has been reported to be closely associated with increased oxidative stress (1,38).…”

Section: Plasma Coq 10-total In Subgroups Of Ckd Patients With Concommentioning

confidence: 99%

The importance of coenzyme Q10 and its ratio to cholesterol in the progress of chronic kidney diseases linked to non- -communicable diseases

Gvozdjáková¹,

Kucharská²,

Sumbalová³

et al. 2020

BLL

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OBJECTIVES: The mortality of patients with chronic kidney diseases (CKD) increases with the decrease in glomerular fi ltration rate (eGFR). In the progress of CKD that is closely linked to non-communicable diseases (NCDs), the role of coenzyme Q 10 (CoQ 10) is not fully evaluated. We aimed to evaluate the importance of CoQ 10, CoQ 10 /cholesterol ratio, and oxidative stress in the progress of CKD. PATIENTS AND METHODS: The control group was constituted of 19 healthy subjects who volunteered to enrol in the study, CKD group consisted of 58 patients with CKD, of whom 54 had CKD combined with hypertension, 22 had CKD combined with hypertension and diabetes type 2 , and 18 had CKD combined with hypertension and statin therapy. We observed age, BMI, creatinine, uric acid, eGFR, hemoglobin, CRP, glucose, lipids fraction, and liver enzymes. Coenzyme Q 10-TOTAL (ubiquinol+ubiquinone) in platelets and plasma were determined using HPLC method with UV detection. Indexed of CoQ 10 /lipid fractions were evaluated. Oxidative stress was determined as thiobarbituric acid-reactive substances (TBARS). RESULTS: With increased stages of CKD, eGFR and CoQ 10 as well as its ratio to lipids were signifi cantly reduced while TBARS increased. CONCLUSION: We assume that lower endogenous CoQ 10 level may be one of the reasons of kidney dysfunction. CoQ 10 /lipids ratio and increase in oxidative stress can predict the progression of CKD in patients with arterial hypertension, diabetes mellitus and dyslipidemia (Tab. 2, Fig. 4, Ref. 49). Text in PDF www.elis.sk KEY WORDS: chronic kidney disease, non-communicable diseases, glomerular fi ltration, creatinine, coenzyme Q 10, oxidative stress, index of CoQ 10-TOTAL /lipids.

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Mitochondrial dysfunction and kidney disease

Cited by 3 publications

References 57 publications

Platelet Mitochondrial Respiration, Endogenous Coenzyme Q10 and Oxidative Stress in Patients with Chronic Kidney Disease

Platelet Mitochondrial Respiration, Endogenous Coenzyme Q10 and Oxidative Stress in Patients with Chronic Kidney Disease

Kidney manifestations of mitochondrial disorders

The importance of coenzyme Q10 and its ratio to cholesterol in the progress of chronic kidney diseases linked to non- -communicable diseases

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