Mitochondrial DNA somatic mutations are frequent in nasopharyngeal carcinoma

Pang, Lei; Shao, Jian Yong; Xiao, Liang; Xia, Yun; Zeng, Yi Xin

doi:10.4161/cbt.7.2.5256

Cited by 25 publications

(23 citation statements)

References 32 publications

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“…It was reported that polymorphisms 73AgG and 263AgG were two of the most common variations in European population and may act as discriminating factors of 5 major mtDNA clusters (Pang et al, 2008). However, our results also showed that these variations are among the most common in both prostate cancer and BPH patients.…”

Section: Discussioncontrasting

confidence: 42%

“…However, our results also showed that these variations are among the most common in both prostate cancer and BPH patients. These variations were found in all patients with nasopharyngeal carcinoma in the study of Pang et al (Pang et al, 2008). In contrast lower prevalence (19%) of these variations were observed in prostate cancer patients in Chen et al's study (Chen et al, 2002).…”

Section: Discussioncontrasting

confidence: 39%

“…Both homoplasmic and heteroplasmic variations of D-loop are reported in previous studies. Homoplasmic alterations, which were most frequent in our study, may have a significant role in the development of neoplasia (Pang et al, 2008). …”

Section: Discussionmentioning

confidence: 87%

“…The mitochondrial non-coding displacement loop (D-Loop) region contains crucial elements for DNA replication and transcription. Mutations in mtDNA can cause impairment of oxidative phosphorylation and increase ROS production which in turn accelerates the DNA mutation rate (Pang et al, 2008). It is reported that the mutation frequency in mtDNA is about 10-to 20-fold greater as compared to nuclear DNA (Copeland et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…There is growing evidence that mitochondrial genetic variation has a role in carcinogenesis (Booker et al, 2006). In human malignancies majority of mtDNA mutations occur in D-Loop region, which has been shown to be a "hot spot" for point mutations in many human cancers (Fliss et al, 2000;Penta et al, 2001;Pang et al, 2008;Sharawat et al, 2010). D-Loop region is highly polymorphic and has two hypervariable segments: HVS1 (16093-16362) and HVS2 (150-372).…”

Section: Introductionmentioning

confidence: 99%

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Mitochondrial D-Loop Polymorphism and Microsatellite Instability in Prostate Cancer and Benign Hyperplasia Patients

Ashtiani

Heidari²,

Hasheminasab³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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In this study mitochondrial D-Loop variations in Iranian prostate cancer and benign prostatic hyperplasia (BPH) patients were investigated. Tumour samples and corresponding non-cancerous prostate tissue from 40 prostate cancer patients and 40 age-matched BPH patients were collected. The entire mtD-loop region (16024-576) was amplified using the PCR method and products were gel-purified and subjected to direct nucleotide sequencing. A total of 129 variations were found, the most frequent being 263AgG and 310TgC among both BPH and prostate cancer patients. Variation of 309 CgT was significantly more frequent in prostate cancer patients (P value<0.05). Four novel variations were observed on comparison with the MITOMAP database. Novel variations were np16154delT, np366GgA, np389GgA and 56insT. There was no correspondence between the different variations and the age of subjects. Considering that D-loop variations were frequent in both BPH and prostate cancer patients in our study, the fact that both groups had high average age can be a possible contributing factor. D-loop polymorphisms and microsatellite instability can influence cell physiology and result in a benign or malignant phenotype. Significantly higher frequency of 309 CgT variation in cancer patients is a notable finding and must be a focus of attention in future studies.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussioncontrasting

confidence: 39%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mitochondrial D-Loop Polymorphism and Microsatellite Instability in Prostate Cancer and Benign Hyperplasia Patients

Ashtiani

Heidari²,

Hasheminasab³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer

et al. 2020

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Epstein-Barr virus (EBV) is a cause for many types of cancers including lymphoma and nasopharyngeal cancers (NPC). 1 It infects the tonsillar B cells and is transmitted to nasopharyngeal epithelium. In these EBV-associated tumors, infection is latent, and only a part of the whole EBV genome is expressed, including six EBV nuclear antigens (EBNA1, −2, −3A, −3B, −3C, and-LP), three latent membrane proteins (LMP1, −2A,-and −2B), and two small RNAs (EBER1 and −2). Among the latent viral genes described above, LMP1 immortalizes B lymphocytes and rodent epithelial cells,

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Mitochondrial Genetic Alterations in Cancer I

Dakubo¹

2010

Mitochondrial Genetics and Cancer

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Mitochondrial DNA somatic mutations are frequent in nasopharyngeal carcinoma

Abstract: Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China

Cited by 25 publications

References 32 publications

Mitochondrial D-Loop Polymorphism and Microsatellite Instability in Prostate Cancer and Benign Hyperplasia Patients

Mitochondrial D-Loop Polymorphism and Microsatellite Instability in Prostate Cancer and Benign Hyperplasia Patients

EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer

Mitochondrial Genetic Alterations in Cancer I

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