Mitochondrial Genetic Alterations in Cancer I

The Interplay between Dysregulated Metabolism and Epigenetics in Cancer

“…With the increasing prevalence of NGS studies, mitochondrial (mt) and nuclear (n) DNA mutations have been identified in numerous cancers including leukemia, breast, lung, liver, kidney, thyroid, ovarian, colon, and brain cancers [ 21 , 23 , 24 , 25 , 26 , 28 , 31 , 32 ]. Unlike nDNA, mtDNA mutations are identified in most cancers with varying prevalence rates ( Table 1 ) [ 251 , 252 ]. Unfortunately, the functional and clinical consequences of the vast majority of these mutations have yet to be elucidated, although many are predicted to impact protein function [ 252 , 253 ].…”