MITOCHONDRIAL DNA POLYMORPHISM AND PATHOGENETICS OF SUDDEN CARDIAC DEATH (review)

doi:10.15372/ssmj20180608

Cited by 1 publication

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Одним из факторов, влияющих на развитие сердечной патологии, является дисфункция митохондрий, которая ассоциирована со снижением синтеза АТФ и увеличением продукции активных форм кислорода, формирующей признаки окислительного стресса. Нарушение функции митохондрий не только снижает сократительную способность миокарда, но и ве- дет к нарушению регуляции ионного баланса, которое, в свою очередь, может вызвать развитие жизнеугрожающей аритмии [3]. Таким образом, митохондриальная дисфункция может являться одним из факторов риска развития внезапной сердечной смерти.…”

Section: Introductionunclassified

Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death

Голубенко

Цепокина

Салахов³

et al. 2019

Fundamentalʹnaâ i kliničeskaâ medicina

View full text Add to dashboard Cite

Aim. To identify associations of mtDNA polymorphisms with sudden cardiac death.Materials and Methods. DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260). The frequencies of the most common European mtDNA haplogroups (H, U, T and J) were determined using restriction fragment length polymorphism analysis. In addition, we performed a comparative analysis using previously published data on mtDNA polymorphisms in the West Siberian population.Results. The distribution of mtDNA haplogroups in the patients who died from sudden cardiac death was similar as in the general population: 40% for haplogroup H, 23% for haplogroup U, 12% for haplogroup T and 6.5% for haplogroup J. We found no significant differences regarding the frequency of mtDNA haplogroups in individuals who died from sudden cardiac death and the population level.Conclusion. We discovered no associations of H, U, T, and J mtDNA haplogroups with sudden cardiac death. These results indicate the necessity of a detailed analysis of mitochondrial genome to determine mtDNA variants associated with sudden cardiac death.

show abstract

Section: Introductionunclassified