Mitochondria targeted nanoparticles to generate oxygen and responsive-release of carbon monoxide for enhanced photogas therapy of cancer

Abstract

Carbon monoxide (CO) based gas therapy has been an emerging strategy for cancer treatment. However, the uncontrolled release of CO and limited therapeutic efficacy of monotherapy are two major obstacles...

HSA-MnO2-131I Combined Imaging and Treatment of Anaplastic Thyroid Carcinoma

“…The HSA-templated MnO 2 NPs were prepared using a biotemplate method. 11 , 12 Manganese chloride (MnCl 2 ) (0.1 M, 1 mL) was slowly added to 50 mg of HSA solution (25 mg/mL, 2 mL) dissolved in 2 mL of water with strong stirring. Then, 350 μL of NaOH (1M) was added to the above solution quickly, and the pH was adjusted to 10 using a pH test paper.…”

A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy

“…22 The primary target of CO is the mitochondria of cancer cells, where it accelerates cellular respiration and leads to O 2 depletion and overproduction of reactive oxygen species, thus damaging mitochondria, depleting ATP, and producing other pro-apoptotic effects. 23,24 In addition, CO can traverse freely in various biofilms and tumor stroma, 25 it has great potential to complement photodynamic therapy (PDT), [26][27][28][29] sonodynamic therapy (SDT), 30 chemodynamic therapy (CDT), [31][32][33] chemotherapy, 34 and photothermal therapy (PTT). 35,36 Integrating the therapeutic CO gas with an enzyme inhibitor may provide additional beneficial effects of CO to the anticancer efficiency of the enzyme inhibitor and thus achieving high therapeutic efficacy.…”

Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

“…Recently, photothermal therapy (PTT), which utilizes the thermal ablation from the absorbed optical energy to inhibit primary tumor growth, has become an attractive cancer therapeutic option with the expectation to obtain satisfactory therapeutic outcomes [17][18][19][20]. In addition, the hyperthermia generated by PTT can trigger host immunity inducing immunogenic cell death (ICD), revealing a promising candidate for adjuvant cancer immunotherapy [21,22].…”