Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

Abstract

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.

A Current Perspective on the Potential of Nanomedicine for Anti-Tuberculosis Therapy

“…The potential of nanoparticles in chemo-immunometabolic therapy to modulate metabolism and immune-cells response for improving the outcomes in chronic human diseases has been demonstrated by several studies [ 76 ]. A nanoparticle-polymer network prepared using ROS-consuming bond-bridged copolymers with bromodomain-containing protein 4 inhibitor JQ1 (DHCRJ) reduced ROS in tumor cells, reduced glucose uptake for lactate production and facilitated tumor suppression in triple-negative breast cancer [ 77 ].…”

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

“…98 Among the various nanomaterials, small-molecule-based, peptide-based, and liposome-based nanosystems have been employed in mitochondrial targeting therapy. 99 Because of the importance of mitochondria in disease prevention and treatment, a growing body of research has focused on their role under different disease circumstances, and most of the related mechanisms of mitochondrial rescue have been previously reviewed. Therefore, this review will focus on the effect of phytochemicals on cancer prevention via mitochondrial dysfunction and the potential of phytochemicals in mitochondrial rescue under different circumstances.…”

Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases

“…Imaging-guided treatment is also prevalent and attractive, which can elevate the biosafety and precision of disease treatment especially for interventional ablation and surgery, and meanwhile can effectively alleviate side effects and complications and repress tumor metastasis or reucrrence. 56 In the laboratory, the development of various MRI CAs has flourished in this field, laying a solid foundation for clinical translation.…”