Mitochondria in the middle: exercise preconditioning protection of striated muscle

Lawler, John M.; Rodriguez, Dinah; Hord, Jeffrey M.

doi:10.1113/jp270656

Cited by 40 publications

(33 citation statements)

References 267 publications

(525 reference statements)

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“…However, this increased oxidative stress may act as a preconditioning and induce upregulation in antioxidant defenses, which leads to diminished levels of oxidative stress when experiencing subsequent pro-oxidant environments [104]. …”

Section: Effects Of Acute and Chronic Exercise On Oxidative Stress Inmentioning

confidence: 99%

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

Pesta

Roden

2017

Curr Diab Rep

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Purpose of ReviewOxidative stress describes an imbalance between production and degradation of reactive oxygen species (ROS), which can damage macromolecules. However, ROS may also serve as signaling molecules activating cellular pathways involved in cell proliferation and adaptation. This review describes alterations in metabolic diseases including obesity, insulin resistance, and/or diabetes mellitus as well as responses to acute and chronic physical exercise.Recent FindingsChronic upregulation of oxidative stress associates with the development of insulin resistance and type 2 diabetes (T2D). While single bouts of exercise can transiently induce oxidative stress, chronic exercise promotes favorable oxidative adaptations with improvements in muscle mitochondrial biogenesis and glucose uptake.SummaryAlthough impaired antioxidant defense fails to scavenge ROS in metabolic diseases, chronic exercising can restore this abnormality. The different metabolic effects are likely due to variability of reactive species and discrepancies in temporal (acute vs. chronic) and local (subcellular distribution) patterns of production.

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Section: Effects Of Acute and Chronic Exercise On Oxidative Stress Inmentioning

confidence: 99%

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

Pesta

Roden

2017

Curr Diab Rep

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“…Clearly, as a NCD, cardiovascular disorders affect a large proportion of the global population as a leading cause of death and disability (29, 42, 150). In addition, vascular disorders not only impact the cardiac system, but also play a significant role in disease progression for other disease entities such as those that involve the nervous system and metabolic disease (36, 151–153). In its self, SIRT1 is critical in controlling cell development, survival, metabolism, life span, and programmed cell death with apoptosis and autophagy.…”

Section: Future Perspectivesmentioning

confidence: 99%

Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease

Maiese¹

2017

CNR

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Noncommunicable diseases (NCDs) contribute to a significant amount of disability and death in the world. Of these disorders, vascular disease is ranked high, falls within the five leading causes of death, and impacts multiple other disease entities such as those of the cardiac system, nervous system, and metabolic disease. Targeting the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) pathway and the modulation of micro ribonucleic acids (miRNAs) may hold great promise for the development of novel strategies for the treatment of vascular disease since each of these pathways are highly relevant to cardiac and nervous system disorders as well as to metabolic dysfunction. SIRT1 is vital in determining the course of stem cell development and the survival, metabolism, and life span of differentiated cells that are overseen by both autophagy and apoptosis. SIRT1 interfaces with a number of pathways that involve forkhead transcription factors, mechanistic of rapamycin (mTOR), AMP activated protein kinase (AMPK) and Wnt1 inducible signaling pathway protein 1 (WISP1) such that the level of activity of SIRT1 can become a critical determinant for biological and clinical outcomes. The essential fine control of SIRT1 is directly tied to the world of non-coding RNAs that ultimately oversee SIRT1 activity to either extend or end cellular survival. Future studies that can further elucidate the crosstalk between SIRT1 and non-coding RNAs should serve well our ability to harness the power of SIRT1 and non-coding RNAs for the treatment of vascular disorders.

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“…114 Of all the potential mechanisms by which exercise training has been shown to induce organ protection, enhanced anti-oxidant activity is best supported by evidence. 112,115–121 …”

Section: Therapeutic Applications Targeting Subcellular Energeticsmentioning

confidence: 99%

Subcellular Energetics and Metabolism: Potential Therapeutic Applications

Thiele

2017

Anesthesia &Amp; Analgesia

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Part I of this review discussed the similarities between embryogenesis, mammalian adaptions to hypoxia (primarily driven by Hypoxia Inducible Factor-1 [HIF-1]), ischemia-reperfusion injury (and its relationship with reactive oxygen species), hibernation, diving animals, cancer, and sepsis, and focused on the common characteristics that allow cells and organisms to survive in these states. Part II of this review describes techniques by which researchers gain insight into subcellular energetics and identify potential future tools for clinicians. In particular, P31 nuclear magnetic resonance to measure high energy phosphates, serum lactate measurements, the use of near infrared spectroscopy to measure the oxidation state of cytochrome aa3, and the ability of the protoporphyrin IX-triplet state lifetime technique to measure mitochondrial oxygen tension are discussed. Additionally, this review will discuss novel treatment strategies such as hyperbaric oxygen, preconditioning, exercise training, therapeutic gases, as well as inhibitors of HIF-1, HIF prolyl hydroxylase (PHD), and Peroxisome proliferator-activated receptors (PPARs).

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Mitochondria in the middle: exercise preconditioning protection of striated muscle

Cited by 40 publications

References 267 publications

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease

Subcellular Energetics and Metabolism: Potential Therapeutic Applications

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