Mitochondria dysfunctions under Fe and S deficiency: is citric acid involved in the regulation of adaptive responses?

Vigani, Gianpiero; Pii, Youry; Celletti, Silvia; Maver, Mauro; Mimmo, Tanja; Cesco, Stefano; Astolfi, Stefania

doi:10.1016/j.plaphy.2018.02.022

Cited by 21 publications

(24 citation statements)

References 41 publications

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“…For instance, in rapeseed, it was reported that S deficiency inhibits the accumulation of Fe in leaves and roots [10]. In tomato, the effect of S deficiency on the accumulation of Fe in leaves was reported to vary from a strong reduction (stronger than Fe deficiency itself) to no effect (as reported for Arabidopsis in this study) [11,15,18]. These observations indicate that the impact of S deficiency on Fe accumulation might be specific to the plant species, the developmental stage and/or the growth conditions.…”

Section: Plos Onesupporting

confidence: 63%

“…In Arabidopsis thaliana, such cross talk between Fe and S homeostasis was also reported, notably through the study of the expression of the main Fe and S transporter present at the root epidermis, namely IRT1 (IRON-REGULATED TRANS-PORTER 1) and SULTR1;1 (SULPHATE TRANSPORTER 1;1), respectively [16]. As expected, these studies also highlighted that Fe and S deficiency impact the expression of a common set of genes that are not directly related to Fe and S acquisition and assimilation, which was in adequacy with the central role that play both nutrients in several key metabolic processes [17][18][19][20].…”

Section: Introductionsupporting

confidence: 65%

“…Arabidopsis, rapeseed, tomato) and mococots (i.e. barley, durum wheat, wheat) species [10][11][12][13][14][15][16][17][18][19][20]. Altogether, these studies have highlighted that modifications in the availability of one nutrient affects the homeostasis of the other, by notably modulating the expression and activity of several genes and proteins involved in these processes.…”

Section: Discussionmentioning

confidence: 99%

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Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency

et al. 2020

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Among the mineral nutrients that are required for plant metabolism, iron (Fe) and sulphur (S) play a central role as both elements are needed for the activity of several proteins involved in essential cellular processes. A combination of physiological, biochemical and molecular approaches was employed to investigate how S availability influences plant response to Fe deficiency, using the model plant Arabidopsis thaliana. We first observed that chlorosis symptom induced by Fe deficiency was less pronounced when S availability was scarce. We thus found that S deficiency inhibited the Fe deficiency induced expression of several genes associated with the maintenance of Fe homeostasis. This includes structural genes involved in Fe uptake (i.e. IRT1, FRO2, PDR9, NRAMP1) and transport (i.e. FRD3, NAS4) as well as a subset of their upstream regulators, namely BTS, PYE and the four clade Ib bHLH. Last, we found that the over accumulation of manganese (Mn) in response to Fe shortage was reduced under combined Fe and S deficiencies. These data suggest that S deficiency inhibits the Fe deficiency dependent induction of the Fe uptake machinery. This in turn limits the transport into the root and the plant body of potentially toxic divalent cations such as Mn and Zn, thus limiting the deleterious effect of Fe deprivation.

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Section: Plos Onesupporting

confidence: 63%

Section: Introductionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency

et al. 2020

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“…Succinic acid was the most abundant organic acid in flowers and non-edible parts (2.55 ± 0.01 g/100 g dw and 1.87 ± 0.06 g/100 g dw, respectively), followed by citric (2.29 ± 0.03 g/100 g dw) and quinic (1.51 ± 0.05 g/100 g dw) acids, respectively. The high amounts of citric, succinic and quinic acids observed in these inflorescence parts may derive from their involvement in the central energy-yielding cycle of the cell, the so-called Krebs cycle (Vigani et al, 2018). In these flowers, succinic acid may appear as a succinyl moiety attached to the sugar of the predominant anthocyanin (cyanidin-3-O-(6-O-succinylglucoside)-5-O-glucoside) found in the colour-giving complex called protocyanin (Yoshida et al, 2009).…”

Section: Composition In Organic Acidsmentioning

confidence: 99%

Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part

Lockowandt

Pinela

Roriz

et al. 2019

Industrial Crops and Products

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114

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Cornflower is a flowering weed and ornamental plant whose blue flowers have been used for food, decorative and colouring purposes. In this study, the upper (edible flowers) and lower (non-edible receptacle and involucre) parts of the capitulum were studied and compared for their chemical composition and bioactive properties. The flowers were richer in tocopherols, organic acids, and apigenin derivatives (mainly apigenin-7-O-glucuronide-4′-O-(6-O-malonylglucoside)) than the non-edible bristly part (where syringic acid predominated). Four cyanidin derivatives were identified in the flowers. The extract of the non-edible part was more efficient in inhibiting the formation of thiobarbituric acid reactive substances (TBARS), the bleaching of β-carotene, and the haemolysis of the erythrocytes membrane. In general, the extracts were more active against Gram-positive bacteria and had no cytotoxicity against non-tumour liver PLP2 cells. Therefore, while flowers are a potential source of natural cyanidin-based colorants, the lower part of the capitulum has bioactive properties to be exploited in different food or pharmaceutical formulations.

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“…Such findings are in agreement with findings for citric acid accumulation in roots as well as in root exudates, indicating that the induction of citric acid is driven mainly by higher pH conditions. Moreover, the accumulation of citric acid in roots constitutes an advantage, as it performs multiple functions in cells (pH-stat, signaling, xylem transport of Fe, carbon skeleton precursor functions) [44,45].…”

Section: Discussionmentioning

confidence: 99%

Temporal Responses to Direct and Induced Iron Deficiency in Parietaria judaica

et al. 2020

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Parietaria judaica grows in highly calcareous environments, overcoming the low bioavailability of Fe caused by elevated pH. The aim of this work was to investigate the temporal dynamics of root exudation of P. judaica under Fe deficiency conditions. As high concentrations of bicarbonate and Ca2+ in calcareous soils interfere with the general plant mineral nutrition, two different alkaline growing conditions were applied to distinguish the effects due to the high pH from the responses induced by the presence of high calcium carbonate concentrations. Growth parameters and physiological responses were analyzed during a 7 day time course—shoot and root biomass, chlorophyll and flavonoid contents in leaves, root accumulation, and exudation of organic acids and phenolics were determined. Different responses were found in plants grown in the presence of bicarbonate and in the presence of an organic pH buffer, revealing a time- and condition-dependent response of P. judaica and suggesting a stronger stress in the buffer treatment. The high tolerance to alkaline conditions may be related to an earlier and greater exudation rate of phenolics, as well as to the synergistic effect of phenolics and carboxylic acids in root exudates in the late response. The identification of the main functional traits involved in tolerance to low Fe availability in a wild species could offer crucial inputs for breeding programs for application to crop species.

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Mitochondria dysfunctions under Fe and S deficiency: is citric acid involved in the regulation of adaptive responses?

Cited by 21 publications

References 41 publications

Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency

Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency

Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part

Temporal Responses to Direct and Induced Iron Deficiency in Parietaria judaica

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