Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency

Robe, Kevin; Gao, Fei; Bonillo, Pauline; Tissot, Nicolas; Gaymard, Frédéric; Fourcroy, Pierre; Izquierdo, Esther; Dubos, Christian

doi:10.1371/journal.pone.0237998

Cited by 16 publications

(9 citation statements)

References 67 publications

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“…Recently, Robe et al (2020) showed that, in Arabidopsis thaliana , the S deficiency-mediated negative regulation of the Fe uptake machinery might be induced to limit the unspecific transport into the root of potentially toxic divalent cations such as Mn and Zn by IRT1 (and other transporters like NRAMP1 ). Such findings highlight the importance to investigate the regulation of Fe/S interplay by considering the interaction of both Fe and S also with other essential nutrients.…”

Section: What Are the Reasons For The Crosstalk Between Sulfur And Iron Nutrition? Are There Common Signals Involved In Their Homeostasismentioning

confidence: 99%

Interaction Between Sulfur and Iron in Plants

et al. 2021

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It is well known that S interacts with some macronutrients, such as N, P, and K, as well as with some micronutrients, such as Fe, Mo, Cu, Zn, and B. From our current understanding, such interactions could be related to the fact that: (i) S shares similar chemical properties with other elements (e.g., Mo and Se) determining competition for the acquisition/transport process (SULTR transporter family proteins); (ii) S-requiring metabolic processes need the presence of other nutrients or regulate plant responses to other nutritional deficiencies (S-containing metabolites are the precursor for the synthesis of ethylene and phytosiderophores); (iii) S directly interacts with other elements (e.g., Fe) by forming complexes and chemical bonds, such as Fe-S clusters; and (iv) S is a constituent of organic molecules, which play crucial roles in plants (glutathione, transporters, etc.). This review summarizes the current state of knowledge of the interplay between Fe and S in plants. It has been demonstrated that plant capability to take up and accumulate Fe strongly depends on S availability in the growth medium in both monocots and dicot plants. Moreover, providing S above the average nutritional need enhances the Fe content in wheat grains, this beneficial effect being particularly pronounced under severe Fe limitation. On the other hand, Fe shortage induces a significant increase in the demand for S, resulting in enhanced S uptake and assimilation rate, similar to what happens under S deficiency. The critical evaluation of the recent studies on the modulation of Fe/S interaction by integrating old and new insights gained on this topic will help to identify the main knowledge gaps. Indeed, it remains a challenge to determine how the interplay between S and Fe is regulated and how plants are able to sense environmental nutrient fluctuations and then to adapt their uptake, translocation, assimilation, and signaling. A better knowledge of the mechanisms of Fe/S interaction might considerably help in improving crop performance within a context of limited nutrient resources and a more sustainable agriculture.

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Section: What Are the Reasons For The Crosstalk Between Sulfur And Iron Nutrition? Are There Common Signals Involved In Their Homeostasismentioning

confidence: 99%

Interaction Between Sulfur and Iron in Plants

et al. 2021

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“…Our results showed that both Fe and S deficiency induced Fe and S-responsive genes, respectively, indicating that plants perceived such deficiencies in our experimental conditions. The effect of S deprivation on Fe deficiency symptoms could be due to a differential accumulation of non-iron metals like Mn and Zn [ 2 ]. In Arabidopsis, the negative regulation (effect) of S deficiency on the Fe uptake machinery induced in response to Fe deficiency can be explained as a need of plants to limit the unspecific transport of potentially toxic divalent cations (Mn and Zn) into the roots through the activity of IRT1 and Nramp1 [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of S deprivation on Fe deficiency symptoms could be due to a differential accumulation of non-iron metals like Mn and Zn [ 2 ]. In Arabidopsis, the negative regulation (effect) of S deficiency on the Fe uptake machinery induced in response to Fe deficiency can be explained as a need of plants to limit the unspecific transport of potentially toxic divalent cations (Mn and Zn) into the roots through the activity of IRT1 and Nramp1 [ 2 ]. Here, we partially observed an effect of –S on Fe deficiency-induced genes: Fe/S interaction could occur in some species or developmental stage with specific mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Here, we partially observed an effect of –S on Fe deficiency-induced genes: Fe/S interaction could occur in some species or developmental stage with specific mechanisms. Indeed, it could not be excluded that growth parameters may also influence these responses [ 2 ]. However, in this work, we observed that GMF differentially affects Mn, Zn, and Cu in the root and leaf tissues, and that MF intensity alters the different impact on the metal content in plants grown under different Fe and S availabilities.…”

Section: Discussionmentioning

confidence: 99%

“…Several pieces of evidence highlight the interplay occurring between Fe and S in plants. For example, it has been reported that S deficiency inhibits the response to Fe deficiency by modulating the expression of genes encoding Fe-regulatory proteins in Arabidopsis thaliana [ 2 ]. Furthermore, in tomato ( Solanum lycopersicum L.) and rapeseed ( Brassica napus L.), S deficiency limits the expression and activity of Fe-deficiency response genes under simultaneous Fe starvation [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Geomagnetic Field (GMF)-Dependent Modulation of Iron-Sulfur Interplay in Arabidopsis thaliana

Vigani

Islam

Cavallaro

et al. 2021

IJMS

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The geomagnetic field (GMF) is an environmental factor affecting the mineral nutrient uptake of plants and a contributing factor for efficient iron (Fe) uptake in Arabidopsis seedlings. Understanding the mechanisms underlining the impact of the environment on nutrient homeostasis in plants requires disentangling the complex interactions occurring among nutrients. In this study we investigated the effect of GMF on the interplay between iron (Fe) and sulfur (S) by exposing Arabidopsis thaliana plants grown under single or combined Fe and S deficiency, to near-null magnetic field (NNMF) conditions. Mineral analysis was performed by ICP-MS and capillary electrophoresis, whereas the expression of several genes involved in Fe and S metabolism and transport was assayed by qRT-PCR. The results show that NNMF differentially affects (i) the expression of some Fe- and S-responsive genes and (ii) the concentration of metals in plants, when compared with GMF. In particular, we observed that Cu content alteration in plant roots depends on the simultaneous variation of nutrient availability (Fe and S) and MF intensity (GMF and NNMF). Under S deficiency, NNMF-exposed plants displayed variations of Cu uptake, as revealed by the expression of the SPL7 and miR408 genes, indicating that S availability is an important factor in maintaining Cu homeostasis under different MF intensities. Overall, our work suggests that the alteration of metal homeostasis induced by Fe and/or S deficiency in reduced GMF conditions impacts the ability of plants to grow and develop.

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