Mitochondria and Cancer

Bazhin, Alexandr V.

doi:10.3390/cancers12092641

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…Monitoring miRNAs in tumor cells is advantageous for distinguishing cell types and tumor progression for clinical diagnosis and treatment , because abnormal expression of miRNAs promoted the differentiation, proliferation, and apoptosis of tumor cells. − miRNAs in mitochondria thus play a significant role in the apoptosis process and cancer diagnosis by directly regulating mitochondrial genes and activity, , such as miR-21 and miR-10b high expression in triple-negative breast cancer during cell apoptosis. − Therefore, accurately monitoring the changes of mitochondrial miRNAs during cell apoptosis is essential for either the study of the mechanism of apoptosis or the development of apoptosis-inducing agents for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Response of Mitochondrial MicroRNAs to Identify Cell Apoptosis with Multiple Responsive Intelligent DNA Biocomputing Nanodevices

Cheng

et al. 2023

Anal. Chem.

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Challenges remained in precisely real-time monitoring of apoptotic molecular events at the subcellular level. Herein, we developed a new type of intelligent DNA biocomputing nanodevices (iDBNs) that responded to mitochondrial microRNA-21 (miR-21) and microRNA-10b (miR-10b) simultaneously which were produced during cell apoptosis. By hybridizing two hairpins (H1 and H2) onto DNA nanospheres (DNSs) that had been previously modified with mitochondria-targeted triphenylphosphine (TPP) motifs, iDBNs were assembled in which two localized catalytic hairpins self-assembly (CHA) reactions occurred upon the co-stimulation of mitochondrial miR-21 and miR-10b to perform AND logic operations, outputting fluorescence resonance energy transfer (FRET) signals for sensitive intracellular imaging during cell apoptosis. Owing to the spatial confinement effects of DNSs, it was discovered that iDBNs had a high efficiency and speed of logic operations by high local concentrations of H1 and H2, making the simultaneous real-time responses of mitochondrial miR-21 and miR-10b reliable and sensitive during cell apoptosis. These results demonstrated that iDBNs were simultaneously responsive to multiple biomarkers, which greatly improved the detection accuracy to identify the cell apoptosis, demonstrating that iDBNs are highly effective and reliable for the diagnosis of major disease and screening of anticancer drugs.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Response of Mitochondrial MicroRNAs to Identify Cell Apoptosis with Multiple Responsive Intelligent DNA Biocomputing Nanodevices

Cheng

et al. 2023

Anal. Chem.

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“…Mitochondria, as essential energy-supplying organelles, has played the crucial roles in many cellular processes, including central metabolism, signal transduction, and cell apoptosis [1]. In cellular systems, mitochondrial viscosity was regarded as a crucial parameter for assessing mitochondrial function, because it was closely associated with the mitochondrial respiratory state [2].…”

Section: Introductionmentioning

confidence: 99%

A Mitochondria-Targeting Fluorescent Probe for the Dual Sensing of Hypochlorite and Viscosity without Signal Crosstalk in Living Cells and Zebrafish

Gao,

Chen,

Zhang

et al. 2024

Preprint

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Hypochlorite (ClO−) and viscosity both affect the physiological state of mitochondria, and their abnormal levels are closely related to many common diseases. Therefore, it is of great significance to develop a mitochondria-targeting fluorescent probes for the dual sensing of ClO− and viscosity. Herein, we have explored a new fluorescent probe XTAP−Bn, which responds sensitively to ClO− and viscosity with off-on fluorescence changes at 558 and 765 nm, respectively. Because the emission wavelength gap is more than 200 nm, XTAP−Bn can effectively eliminate the signal crosstalk during the simultaneous detection of ClO− and viscosity. In addition, XTAP−Bn exhibits a series of advantages, including high selectivity, rapid response, good water solubility, low cytotoxicity, and excellent mitochondrial targeting ability. More importantly, probe XTAP−Bn has been successfully employed to monitor the dynamic change of ClO− and viscosity levels in mitochondria of living cells and zebrafish. Taken together, this work not only provides a reliable tool for identifying mitochondrial dysfunction, but also offers a potential approach for the early diagnosis of mitochondrial-related diseases.

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“…[ 20 ] Therefore, mitochondrial dysfunction is considered a decisive signal of the intrinsic apoptosis pathway [ 21 ] and is closely associated with programmed cell death. [ 22 ] Compared with other organelles, the mitochondrion has a unique advantage of mitochondrial transmembrane potential (ΔΨm)difference of 180–200 mV (external positive and internal negative). The ΔΨm with −220 mV in tumor cells is more hyperpolarized than that in normal cells (−140 mV), [ 23 ] contributing to providing a charge target for antitumor therapy.…”

Section: Introductionmentioning

confidence: 99%

NIR‐II Imaging‐Guided Mitochondrial‐Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy

Yang

Sun

Liu

et al. 2023

Small

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Effectively interfering energy metabolism in tumor cells and simultaneously activating the in vivo immune system to perform immune attacks are meaningful for tumor treatment. However, precisely targeted therapy is still a huge challenge. Herein, a mitochondrial‐targeting phototheranostic system, FE‐T nanoparticles (FE‐T NPs) are developed to damage mitochondria in tumor cells and change the tumor immunosuppressive microenvironment. FE‐T NPs are engineered by encapsulating the near‐infrared (NIR) absorbed photosensitizer IR‐FE‐TPP within amphiphilic copolymer DSPE‐SS‐PEG‐COOH for high‐performing with simultaneous mitochondrial‐targeting, near‐infrared II (NIR‐II) fluorescence imaging, and synchronous photothermal therapy (PTT) /photodynamic therapy (PDT) /immune therapy (IMT). In tumor treatment, the disulfide in the copolymer can be cleaved by excess intracellular glutathione (GSH) to release IR‐FE‐TPP and accumulate in mitochondria. After 808 nm irradiation, the mitochondrial localization of FE‐T NPs generated reactive oxygen species (ROS), and hyperthermia, leading to mitochondrial dysfunction, photoinductive apoptosis, and immunogenic cell death (ICD). Notably, in situ enhanced PDT/PTT in vivo via mitochondrial‐targeting with FE‐T NPs boosts highly efficient ICD toward excellent antitumor immune response. FE‐T NPs provide an effective mitochondrial‐targeting phototheranostic nanoplatform for imaging‐guided tumor therapy.

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Mitochondria and Cancer

Abstract: Mitochondria are indispensable for energy metabolism and are essential for the regulation of many cellular processes in healthy as well as in transformed cells [...]

Cited by 9 publications

References 6 publications

Simultaneous Response of Mitochondrial MicroRNAs to Identify Cell Apoptosis with Multiple Responsive Intelligent DNA Biocomputing Nanodevices

Simultaneous Response of Mitochondrial MicroRNAs to Identify Cell Apoptosis with Multiple Responsive Intelligent DNA Biocomputing Nanodevices

A Mitochondria-Targeting Fluorescent Probe for the Dual Sensing of Hypochlorite and Viscosity without Signal Crosstalk in Living Cells and Zebrafish

NIR‐II Imaging‐Guided Mitochondrial‐Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy

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